ABSTRACT
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the five sessions with a 2 weeks wash out period in-between. Paracetamol alone was used as control. This was compared with concomitant administration with Cimetidine and then delayed (l hour later) administration of paracetamol after Cimetidine. Diazepam was used in phase IV and V under the same protocol of concomitant administration with paracetamol and delayed administration of paracetamol l hour of diazepam. Ultraviolet spectrophotometer was used to determine the saliva concentration of paracetamol. Pharmacokinetic parameters (Kab, t1/2el, t1/2(ab), Kel, Kab, lag time were determined by plotting paracetamol concentrations against time on a logarithmic scale while other parameters were calculated. There was no significant effect (p > 0.05) on the parameters on concomiittant administration for both drugs (cimetidine and diazepam) when compared to the control. However, on delayed administration of paracetamol 1 hour after administration of diazepam, Tmax and lag time were greatly reduced 31.11 % and 50 % repectively P < 0.05. T1/2(ab) and Kel were significantly increased 48.42 % and 54.57 % P < 0.05 respectively. The volume of distribution (Vd) and clearance (Cl) were not significantly affected P > 0.05. Delayed administration of paracetamol 1 hour after cimetidine affected all the parameters Cmax and Kab were significantly reduced P < 0.05 by 30.02 % and vii 45.06 % respectively. While Tmax, t1/2(ab) and lag time were significant increased (p < 0.05) by 47.97 %, 42.32 % and 60.13 % respectively. Clearance (Cl) and Kel were reduced significantly (P < 0.05) by 20.75 % and 42,76 % respectively. T1/2(el) and AUC0 - ∞ were increased by 39.20 % and 29.08 % respectively. The above findings show that concomitant administration of paracetamol + diazepam and of paracetamol + cimetidine does not cause any effect on the kinetics of paracetamol. On the other hand, delayed administrations of paracetamol one hour after cimetidine show decrease in absorption and delayed elimination probably due to delay in gastric emptying and inhibition of metabolism respectively. Administration of paracetamol one hour after diazepam ingestion shows increase in absorption and change in other pharmacokinetic parameters due to enhanced gastric emptying and amplitude of contraction.
ABSTRACT
The study evaluated the impact of personal selling on sales volume. The research survey design was adopted in the study while si...
ABSTRACT
This study was carried out to examine Effects of increase in tuition fees on business ed...
ABSTRACT
This study investigates the twenty five years of merchant banking in Nigeria. It evaluates the operation of merchant bank on eco...
Abstract: This study addresses the digital divide in accessing technical education in Niger...
ABSTRACT
This project titled “the Indispensability of accountin...
THE ROLE OF INFORMATION SYSTEMS IN SUPPLY CHAIN MANAGEMENT
Abstract: This study aimed to explore...
ABSTRACT
This study was carried out to examine the influence of customer relationship management o...
Abstract
The purpose of the study was to investigate the rising cost of education and its implication on the youth in pu...
Abstract
Human resources management remains indispensable in engendering competitive advantage of any firm in thi...
ABSTRACT
The necessity of building a workable synergy and desirable relationship between the forces of government both a...