COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the five sessions with a 2 weeks wash out period in-between. Paracetamol alone was used as control. This was compared with concomitant administration with Cimetidine and then delayed (l hour later) administration of paracetamol after Cimetidine. Diazepam was used in phase IV and V under the same protocol of concomitant administration with paracetamol and delayed administration of paracetamol l hour of diazepam. Ultraviolet spectrophotometer was used to determine the saliva concentration of paracetamol. Pharmacokinetic parameters (Kab, t1/2el, t1/2(ab), Kel, Kab, lag time were determined by plotting paracetamol concentrations against time on a logarithmic scale while other parameters were calculated. There was no significant effect (p > 0.05) on the parameters on concomiittant administration for both drugs (cimetidine and diazepam) when compared to the control. However, on delayed administration of paracetamol 1 hour after administration of diazepam, Tmax and lag time were greatly reduced 31.11 % and 50 % repectively P < 0.05. T1/2(ab) and Kel were significantly increased 48.42 % and 54.57 % P < 0.05 respectively. The volume of distribution (Vd) and clearance (Cl) were not significantly affected P > 0.05. Delayed administration of paracetamol 1 hour after cimetidine affected all the parameters Cmax and Kab were significantly reduced P < 0.05 by 30.02 % and vii 45.06 % respectively. While Tmax, t1/2(ab) and lag time were significant increased (p < 0.05) by 47.97 %, 42.32 % and 60.13 % respectively. Clearance (Cl) and Kel were reduced significantly (P < 0.05) by 20.75 % and 42,76 % respectively. T1/2(el) and AUC0 - ∞ were increased by 39.20 % and 29.08 % respectively. The above findings show that concomitant administration of paracetamol + diazepam and of paracetamol + cimetidine does not cause any effect on the kinetics of paracetamol. On the other hand, delayed administrations of paracetamol one hour after cimetidine show decrease in absorption and delayed elimination probably due to delay in gastric emptying and inhibition of metabolism respectively. Administration of paracetamol one hour after diazepam ingestion shows increase in absorption and change in other pharmacokinetic parameters due to enhanced gastric emptying and amplitude of contraction.
Related Project Materials
THE LAND USE ACT OF 1978: APPRAISAL, PROBLEMS AND PROSPECTS
ABSTRACT
From time immemorial through the period of agriculture to the period of industrial development, land has remained the most...
CRITICAL ANALYSIS OF THE CAUSES AND EFFECT OF MASS FAILURE OF MATHEMATICS IN SENIOR SECONDARY SCHOOL CERTIFICATE EXAMINATION
ABSTRACT
There has been a problem for some years now, student’s poor academic performance in senior secondary Scho...
GOVERNMENT EXPENDITURE AND ECONOMIC GROWTH IN NIGERIA (1981 - 2015)
ABSTRACT
This study examined government expenditure and Nigeria’s economic growth within the samp...
THE ROLE OF EARLY CHILDHOOD EDUCATION IN REDUCING SCREEN TIME
ABSTRACT: The role of early childhood education in reducing screen time is...
PROBLEMS AND PROSPECTS OF REVENUE GENERATION IN NIGERIA LOCAL GOVERNMENT SYSTEM
ABSTRACT
This study is on the impact of local government finance on efficient service delivery in Nigeria. The study exa...
PERCEPTION OF DRUG USE AND ABUSE ON STUDENTS BEHAVIOUR IN PUBLIC SECONDARY SCHOOLS
ABSTRACT
This study was conducted to find out the perception of drug use and abuse on student’s behavior in public...
EVALUATION OF THE IMPACT OF ECONOMIC EMPOWERMENT AND DEVELOPMENT STRATEGY ON POVERTY ALLEVIATION IN TARABA STATE
ABSTRACT
The study evaluates the impact of Taraba State Economic Empowerment and Devel...
IMPACT OF SOCIAL MEDIA IN MANAGING BRAND REPUTATION IN CRISES
Abstract
The research provides a conceptual and theoretical appraisal of the impact of social media in managing. As soc...
REVENUE MOBILIZATION AS A TOOL FOR EFFECTIVE LOCAL GOVERNMENT ADMINISTRATION
ABSTRACT
This study focuses on Revenue Mobilization as a tool for effective Local Government Administra...
ROLE OF PURCHASING IN THE ACHIEVEMENT OF ORGANIZATIONAL OBJECTIVE
Abstract
This topic role of purchasing in the achievement of an organizational objective has been chose in order to brin...
