1. ANTICONVULSANT STUDIES OF THE METHANOL EXTRACT AND FRACTIONS OF CASSIA SIAMEA LAM. (FABACEAE) IN MICE AND CHICKS
ABSTRACT
Cassia siamea is a shrub belonging to the Fabaceae family, native of Southeast Asia. The plant is commonly used in traditional medicine to treat hypertension, malaria and diabetes. Due to the easy cultivation of the plant, its widespread and also remarkable biological activitie...
2. COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at...
3. BEHAVIOURAL AND ANTICONVULSANT EFFECTS OF METHANOL EXTRACT OF FICUS VALLIS CHOUDAE (MORACEAE) STEM BARK
ABSTRACT
Ficus vallis choudae is a plant widely spread in tropical Africa including Nigeria. It is said to be of value in ethnomedicine especially in the treatment of jaundice, gastrointestinal problems, giddiness and epilepsy. The anticonvulsant activity of methanol stem bark extract o...
4. ANXIOLYTIC PROPERTIES OF MITRACARPUS VILLOSUS (SW) DC.LEAF EXTRACTS IN MICE AND RATS
ABSTRACT
The leaf of Mitracarpusvillosus (Sw.) DC. (Rubiaceae) is used in West African folk medicine for the management of a plethora of stress-related diseases including headaches and toothaches. In this study, preliminary phytochemical analysis of the ethylacetateleaf extract of Mitra...
5. PHARMACOTHERAPEUTICS OF MOOD DISORDERS IN PATIENTS ATTENDING NEURO PSYCHIATRIC CLINIC, AHMADU BELLO UNIVERSITY TEACHING HOSPITAL (ABUTH) ZARIA-NIGERIA
ABSTRACT
Mood disorders (primary major depressive disorder and bipolar affective disorder) constitute one of the world’s greatest public health problems and are associated with significant reductions in productivity, health and longevity. This study involved a retrospective analys...
6. PHYTOCHEMICAL AND SOME PHARMACOLOGICAL STUDIES OF THE AERIAL PART OF ALYSICARPUS OVALIFOLIUS Schumach & Thonn FAMILY: FABACEAE
ABSTRACT
Alysicarpus ovalifolius (Schum.&Thonn) Family: Fabaceae is a protein rich fodder plant that is widely distributed across Africa, Asia and Australia and medicinally used to treat cough and wounds. Recently, it has been reported to be used in the Northern part of Nigeria as t...
7. SOME NEUROPHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF THE ETHANOLIC LEAF EXTRACT OF CUSSONIA BARTERI SEEMAN (ARALIACEAE) IN LABORATORY ANIMALS
ABSTRACT
Cussonia barteri is used in traditional medicinefor the management of convulsion and epilepsy, especially in children in Ghana and Nigeria. Literature survey revealed that the safety and efficacy of such important medicinal plant have not been scientifically validated. In the p...
8. SOME NEUROPHARMACOLOGICAL STUDIES ON ETHANOL EXTRACT AND FRACTIONS OF TAPINANTHUS GLOBIFERUS A. RICH MISTLETOE ON VITELLARIA PARADOXA HOST IN LABORATORY ANIMALS
ABSTRACT
Tapinanthus globiferus is a semi-parasite mistletoe which grows on branches of large number of trees including Vitellaria paradoxa. It used locally in the management of insomnia, epilepsy, anxiety, headaches and hypertension. This study evaluated the toxicity and neuropharmacol...
9. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3 ISOMERS OF 4-[(DIMETHYLPHENYL)AMINO]-4-OXOBUTENOIC ACID
ABSTRACT
Epilepsy is a disorder of public concern worldwide and has been widely treated via pharmacotherapy, which are faced with challenges such as cost of therapy, side effects, toxicity and lack of selectivity. As such, researchers agree on the need to identify more selective, readil...
10. EVALUATION OF NOOTROPIC ACTIVITY OF METHANOL STEM EXTRACT OF PARQUETINA NIGRESCENS AFZEL IN MICE
ABSTRACT
Parquetina nigrescens is a plant with numerous ethnomedicinal uses in African traditional medicine practice. In the South Western part of Nigeria, the stems and roots are roasted, powdered then mixed with pap taken as memory enhancer and for its antiaging effect. This study the...
11. PHARMACOLOGICAL RATIONALE FOR THE USE OF SOME MEDICINAL PLANTS AS ANTIEPILEPTIC AGENTS IN NIGERIA
ABSTRACT
The effects of the hydro-alcoholic root bark extracts of C. edulis and B. aegyptiaca were studied on pentylenetetrazole (PTZ) and Maximal electroshock (MES)-induced seizures in animal models. The effects of Flumazenil and Naloxone were studied on the anticonvulsant activity of...
12. SOME NEUROPHARMACOLOGICAL PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS INGENS (MIQUEL) MIQUEL IN MICE AND CHICKS
ABSTRACT
Ficus ingens (Miquel) Miquel belongs to the Moraceae family. In some African countries, extracts of the bark are administered to cows with a low milk production, and to people suffering from anaemia, piles and diarrhea. The behavior of living organisms is a visible manifestatio...
