1. COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at...
2. COMPARISON OF THE EFFECTS OF CIMETIDINE AND TRAMADOL ON THE DISPOSITION OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
The influence of cimetidine (400mg) and Tramadol (100mg) on the disposition of oral single dose (1g) Paracetamol was studied and compared in 8 healthy human volunteers under two protocols; concomitant and delayed paracetamol administration. Subjects received one treatment at ea...
3. COMPARISON OF THE EFFECTS OF CIMETIDINE AND METHYLDOPA ON THE PHARMACOKINETICS OF PARACETAMOL IN HUMAN
ABSTRACT
Comparison of the effects of cimetidine and methyldopa were studied in 5 phases: via phase I, ingestion of paracetamol 1g alone, phase II, administration of paracetamol 1g and cimetidine 400mg concurrently, phase III administration of cimetidine 400mg followed by paracetamol 1g...
4. COMPARATIVE BIOAVAILABILITY STUDIES OF PARACETAMOL BRANDS IN HUMANS
ABSTRACT
The comparative bioavailabilities (bioequivalence) of five generic brands of paracetamol were compared in six (6) healthy male volunteers. The aim was to study whether the generic brands are bioequivalent to the standard brand. The study was carried out following oral administr...
5. COMPARISON OF THE EFFECT OF A SINGLE ORAL DOSE OF CIMETIDINE AND PROPANTHELINE ON THE PHARMACOKINETIC OF PARACETAMOL IN HUMAN
ABSTRACT
Comparison of the effects of a single oral dose of cimetidine and propantheline on the pharmacokinetics of paracetamol were studied with paracetamol (1g) administered alone, concurrently with cimetidine (400mg), delay (1 hour) with cimetidine (400mg), concurrently with paraceta...
6. EVALUATION OF PHARMACOGNOSTICPARAMETERS AND HEPATOTOXIC EFFECTS OF EXTRACTSOF CASSYTHA FILIFORMIS LINN ON PARACETAMOL-INDUCED LIVER DISORDERS IN WISTER RATS
ABSTRACT
Cassytha filiformis, a leafless and perennial vine with small scales as a replacement of the leavesis currently being used in the treatment of various disease conditions including jaundice without standardization.Microscopical evaluation, chromatographic analysis (TLC, HPLC, LC...
7. EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT
ABSTRACT
The aim of this research was to study the tableting properties of Solenostemon rotundifolius starch (SRS) and modified forms for use as pharmaceutical excipient by wet granulation method of tablet production in paracetamol formulation. The physicochemical properties of native a...
8. EFFECT OF CAFFEINE ON PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS: A CASE STUDY OF PANADOL EXTRA®
ABSTRACT
Acetaminophen or paracetamol is an analgesic and anti-pyretic agent widely used for treatment of headaches, minor pains and in combination with other medications like cold remedies and opoid analgesics. Individuals with headaches and minor pains tend to use paracetamol with caf...
9. EVALUATION OF THE BINDING AND SUSPENDING PROPERTIES OF BAGGASE-DERIVED METHYLCELLULOSE
ABSTRACT
Sourcing of raw materials for use in pharmaceutical industries is a continuing challenge. Excipients, which form the bulk of a dosage form, are derived either from natural sources or synthesized wholly or semi-synthesized. The absence of an ideal excipient material continues to...
10. THE AMELIORATIVE EFFECT OF ACACIA SIEBERIANA D.C. METHANOL ROOT BARK EXTRACT ON INDUCED LIVER INJURY AND ITS SUBCHRONIC TOXICITY PROFILE IN RATS
ABSTRACT
Acacia sieberiana D.C is traditionally used as a remedy for various ailments including hepatitis. The effect of methanol root bark extract of Acacia sieberiana (ASE) on paracetamol (PCM) - and bile duct ligation (BDL) –induced liver injury wereinvestigated in rats. Rats w...
11. DEVELOPMENT AND EVALUATION OF A CO-PROCESSED EXCIPIENT FROM ACID HYDROLYZED CASSAVA STARCH, GELATIN AND LACTOSE (STARGELAC) IN TABLET FORMULATIONS
ABSTRACT
Co-processed excipients are a mixture of two or more existing excipients at subparticle level. These multipurpose excipients have significantly reduced the number of incorporating excipients in the tablet. The aim of this work is to design and prepare a coprocessed excipient fr...
12. EVALUATION OF MILLET STARCHES (Pennisetum glaucum and Pennisetum americanum) AS TABLET BINDERS AND DISINTEGRANTS
Abstract
Starch was extracted from the two varieties of millet (Pennisetum glaucum and Pennisetum americanum) by the wet extraction method, the percentage yield was determined. The physicochemical properties investigated includes: flow rate, angle of repose, carr’s index, tapped d...
13. PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON THE SEEDS OF JATROPHA CURCAS LINN. (EUPHORBIACEAE)
ABSTRACT
Jatropha curcas Linn. (Euphorbiaceae) is a shrub that grows up to 5m in height. It thrives well in tropical countries. It grows in the wild as an uncultivated, non-food plant. It is traditionally used as a living fence to protect gardens from animals. An ethnobotanical survey o...
14. THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS
ABSTRACT
The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official me...
