ABSTRACT
Crateva adansonii is a medicinal herb commonly used in parts of Africa because of the side effects of Non-Steroidal Anti-inflammatory Drugs (NSAID), like heart diseases and kidney failure. Inflammation is a major public heart issue in the world but treatment is becoming complex because of the side effects of antiinflammatory pharmaceutical drugs. Hence the need for alternative drug is highly required. This research work investigated the anti-inflammatory activity of dichloromethane fraction of methanol extract of Crateva adansonii stem bark, using rodent model. Adult Swiss albino rats (110-200g) of either sex were randomlydivided into 5 groups of 4 animals each. Groups 2, 3, 4, and 5 received different doses of the extract (300mg, 500mg, 700mg, and 900mg) in 3% v/v tween 80 administered intraperitonally respectively. Control group-1 received volume of 3%v/v tween 80 and standards group received 100mg/kg Ibuprofen. One hour later acute inflammation was induced by injection of 0.1ml of undiluted egg albumin into the sub planter of the right hand paw of rats. The volume of the paw was measured by mercury displacement before and at 0.5, 1, 1.5, 2, 2.5 & 3 hours after egg albumin injection, while the standard was measured at internals of one hour, for up to 4 hours. Edema formation was assessed in terms of the difference in the zero time per volume of the injected pair and its volume at the different time after egg albumin injection. For each dose of extract, percentage inhibition of edema was calculated percentage inhibition. Result show that Crateva adansonii may have anti-inflammatory effects. This finding supports the use stem bark of Crateva adansonii in not only traditional medicine for the treatment of inflammation.
Abstract
The study examines the role of mass media in promoting anti corruption campaigns in Nige...
Abstract
This study is on election violence and democratic stability in Nigeria. The total population for the study is 2...
BACKGROUND OF THE STUDY
The coronavirus disease of 2019 (COVID-19) pandemic gripped the world with a sh...
Abstract
The purpose of the study was to carry out a preliminary investigation on budgetary control and improved perform...
Background of the study
The advent of the internet has revolutionized many aspects of human life, inclu...
BACKGROUND TO THE STUDY
Christianity in Nigeria which has led to planting of churches dates back to the 16th centur...
ABSTRACT
We have been studying a critical issue...
ABSTRACT
This project work is design to investigate the effect of teachers’ qualification and instructional materi...
BACKGROUND
Heart beat rate means the number of heartbeats per unit time, usually expressed as beats per minute (bpm). The human heart pou...
ABSTRACT
This study investigated the effect ofenriched expository method on interest and performance in geometry among Junior Secondary S...