THE ANTI-INFLAMMATORY ACTIVITY OF Crateva adansonii DICHLOROMETHANE FRACTION.
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Crateva adansonii is a medicinal herb commonly used in parts of Africa because of the side effects of Non-Steroidal Anti-inflammatory Drugs (NSAID), like heart diseases and kidney failure. Inflammation is a major public heart issue in the world but treatment is becoming complex because of the side effects of antiinflammatory pharmaceutical drugs. Hence the need for alternative drug is highly required. This research work investigated the anti-inflammatory activity of dichloromethane fraction of methanol extract of Crateva adansonii stem bark, using rodent model. Adult Swiss albino rats (110-200g) of either sex were randomlydivided into 5 groups of 4 animals each. Groups 2, 3, 4, and 5 received different doses of the extract (300mg, 500mg, 700mg, and 900mg) in 3% v/v tween 80 administered intraperitonally respectively. Control group-1 received volume of 3%v/v tween 80 and standards group received 100mg/kg Ibuprofen. One hour later acute inflammation was induced by injection of 0.1ml of undiluted egg albumin into the sub planter of the right hand paw of rats. The volume of the paw was measured by mercury displacement before and at 0.5, 1, 1.5, 2, 2.5 & 3 hours after egg albumin injection, while the standard was measured at internals of one hour, for up to 4 hours. Edema formation was assessed in terms of the difference in the zero time per volume of the injected pair and its volume at the different time after egg albumin injection. For each dose of extract, percentage inhibition of edema was calculated percentage inhibition. Result show that Crateva adansonii may have anti-inflammatory effects. This finding supports the use stem bark of Crateva adansonii in not only traditional medicine for the treatment of inflammation.
Related Project Materials
MANAGEMENT AND USE OF LEGAL DEPOSIT MATERIALS BY LIBRARIES FOR EFFECTIVE USER SUPPORT IN THE NATIONAL LIBRARY OF NIGERIA
Background Of The Study
Different libraries exist for different purposes. These purposes include function, type of users...
DESIGN_AND_IMPLEMENTATION_OF_AN_AUTOMATED_INVENTORY_CONTROL_SYSTEM_FOR_A_MANUFACTURING_ORGANIZATION
BACKGROUND OF THE STUDY
The Petroleum Equalisation Fund Management Board is a scheduled Parastatal of the Ministry of Petroleum Res...
IMPACT OF BAD DEBT IN COMMERCIAL BANK LENDING IN NIGERIA
ABSTRACT
In carry out this research, Attempts was made to evaluate the causes and the effect of bad bests in banks&rsquo...
IMPACT OF ADULT EDUCATION ON CAREER TRANSITION
Abstract: This study explores the impact of adult education on career transition, focusing on how continuing education programs facilitate the...
EFFECT OF MACROECONOMIC DETERMINANT OF CAPITAL MARKET PERFORMANCES IN NIGERIA
Abstract
In the face of capital deficiency in financing long term development, the capital-deficient economies have...
AN EVALUATION OF CONFLICT RESOLUTION STRATEGIES ADOPTED BY SCHOOL PRINCIPALS IN ABIA STATE
Background of the study
Conflict resolution tactics are methods for resolving disagreements. They enabl...
THE IMPACT OF BUDGETING ON STRATEGIC RESOURCE MANAGEMENT
THE IMPACT OF BUDGETING ON STRATEGIC RESOURCE MANAGEMENT
This study aims to: (1) investigate the impact of budgeting on strategic resourc...
CIVIL SERVANT INDISCIPLINE AND ITS EFFECT ON WORK PRODUCTIVITY
ABSTRACT
This research presents the investigation into the effects of civil servant indiscipline on work productivit...
FACTORS AFFECTING THE ACCEPTANCE OF ELECTRONIC VOTING SYSTEMS IN NIGERIA UNIVERSITIES
ABSTRACT
Using electronic voting systems is divisive as some countries used such systems and others did not. This thesis discusses countr...
Holmes: An Open-source Image Forensics Toolkit
ABSTRACT
Digital images continue to be ever-present in our daily lives as means of conveying information. With the avail...
