ANTI-PLASMODIAL EFFECTS OF POLYALTHIA LONGIFOLIA (VAR.) LEAF EXTRACTS AGAINST PLASMODIUM BERGHEI IN MICE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT Malaria is one of the most debilitating tropical parasitic diseases and the greatest cause of hospitalization and death. Recurring problems of drug resistance are reinforcing the need for finding new antimalarial drugs. In this respect, natural plant products are the main sources of biologically active compounds and have potential for the development of novel antimalarial drugs. The present study was designed to elucidate bioactive metabolite and in vivo antimalaria efficacy of crude and solvent fractions of Polyalthia longifolia against Plasmodium berghei in mice. The crude methanol extract of the plant was analysed for the presence of bioactive metabolites following standard procedure. A rodent malaria parasite, Plasmodium berghei, was used to inoculate healthy male Swiss Albino mice of age 6–8 weeks and weight 28– 35 g. Crude methanol extract and the solvent fractions were administered at different doses 150, 300 and 600 mg/kg. Parasitaemia, survival time, body weight, and packed cell volume were determined using standard tests. The results indicated the presence of phytochemicals including flavonoids, phenols, tanins, and alkaloids. Saponin content (500.76±2.37 mg/100 g) was significantly higher than other phytochemicals detected. Acute oral toxicity bioassay reveals an LD50 extrapolated to be above 1600 mg/kg body weight. The crude extract at doses 600 mg/kg b.wt showed appreciable antiplasmodial potency than the fraction. The crude extract prevented loss of weight and slightly affected packed cell volume. The solvent fraction also prevented loss in packed cell volume. All doses of crude extracts and fractions of P. longifolia leaf prolong the survival time of infected mice in a dose dependent pattern. The results collectively indicate that the plant has a promising antiplasmodial activity against Plasmodium berghei, which upholds the earlier in vitro findings as well as its folkloric use
Related Project Materials
THE ROLE OF MEDIA IN NATIONAL CRISIS (A CASE STUDY OF ENDBADGOVERNMENT PROTEST)
Background of the Study
The role of media in shaping public discourse, especially during national crise...
Perception of business education student on relevance of entrepreneurship education at collage of education
Abstract
The purpose of entrepreneurial training as stipulated by the European Commission 2008, among others include; r...
COMPARATIVE ASSESSMENT OF FACTORS AFFECTING COST OF INDUSTRIALIZED BUILDING AND CONVENTIONAL BUILDING SYSTEM IN NIGERIA
ABSTRACT
The main aim of this research work is to compare the factors affecting cost of industrialized building and...
THE IMPACT OF RADIO MUSICAL PROGGRAMMES ON NIGERIAN YOUTHS
Abstract
This study contains an analysis of the broad areas presumed scientific research which have sho...
IMPACTS OF COMPUTER-ASSISTED INSTRUCTION ON STUDENTS’ PERFORMANCE IN CIVIC EDUCATION IN SENIOR SECONDARY SCHOOLS, KADUNA STATE, NIGERIA
ABSTRACT
The study investigated the impact of computer assisted instruction on students‟ academic performance in civic education in senio...
DESIGN AND IMPLEMENTATION OF OFFICE MANAGEMENT SYSTEM
ABSTRACT
The research work “design and implementation of office management system” includes registration of...
INFLUENCE OF WELFARE FACTORS ON SITES WORKERS' PERFORMANCE
ABSTRACT
The purpose of this study was to assess the influence of welfare on the performance of building site workers at...
ASSESSMENT OF PROBLEMS AND ACHIEVEMENT IN PRIMARY HEALTH CARE ACTIVITIES IN BAUCHI METROPOLIS PRIMARY HEALTH CARE SETTING
BACKGROUND OF T
Background to the Study A nation’s progress is largely judged by the extent of productivity it ac...
ABSTRACT This study was carried out to was to investigate godfatherism and electoral process in Nigeria...
SOCIO ETHICAL IMPLICATIONS OF UNEMPLOYMENT AMONG NIGERIAN YOUTHS
GODFATHERISM AND ELECTORAL PROCESS IN NIGERIAN POLITICS
