1. EFFECT OF VITAMINS C AND E ON MEMORY IN ADULT MICE
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement and is destroyed by heat or reduced by prolonged storage (Weinstein et al., 2001). Humans, unlike most...
2. EFFECT OF COVID-19 ON BANKING SYSTEM IN NIGERIA
BACKGROUND OF THE STUDY
A pandemic is a disease outbreak that spreads across countries or continents. It affects more people and takes more lives than an epidemic, which according to the World Health Organization (WHO) declared COVID-19 to be a pandemic...
3. THE LINK BETWEEN LEPTIN AND ANTHROPOMETRIC PARAMETERS IN TYPE 2 DIABETIC PATIENTS
INTRODUCTION
The obese (ob) gene is responsible for the production of the 167-amino-acid protein known as leptin, which is found in both mice and human individuals (Abubakaria & Bhopalb 2021). The quantity of the hormone that is produced is closely associated with t...
4. INVESTIGATION INTO THE CAUSES AND PREVENTION OF COVID-19 AMONG ALVAN IKOKU FEDERAL COLLEGE OF EDUCATION, OWERRI
Background to the study
Etymologically, Coronavirus (COVID-19) are positive-sense, single stranded RNA viruses and its diameters is 60 nm to140 nm with spike like projection on it’s around which giving it a crown like appearance. Their viral is RN...
5. EVALUATION INTO COVID-19 SAFETY COMPLANCE LEVEL IN SECONDARY SCHOOLS
BACKGROUND OF STUDY
Coronavirus pandemic 2019 (COVID-19) is the most recent infectious illness to spread fast over the world (Van Doremalen, 2020), to the point of causing a devastating global pandemic [McDowel, 2020]. COVID-19 is caused by the severe a...
6. FEEDS AND FEEDING OF SHEEP AND GOAT
ABSTRACT
Comparisons were made between 25 Ethiopian rams and 25 Galla goats for voluntary intake Two separate studies to evaluate alternative methods of processing Acacia nilotica pods and level of replacement of cotton seed cake with Acacia pods; an...
7. A STUDY OF MODIFICATIONS OF FILLER DIMENSIONS AND THE EFFECT OF PHYSICAL AND MECHANICAL PROPERTIES OF PINEAPPLE LEAF FIBRE REINFORCED POLYPROPYLENE COMPOSITES
ABSTRACT
This research studied the effect of filler dimensions on some major properties of pineapple leaf fibre-reinforced polypropylene composites. In this study, composites of PALF/PP were produced, the PALF were extracted from pineapple leaves. This was achieved by adopting the mecha...
8. DEVELOPMENT OF BAOBAB/SISAL REINFORCED LOW DENSITY POLYETHYLENE HYBRID COMPOSITE
Abstract
In this work, the properties of baobab/sisal fibre reinforced low density polyethylene hybrid composites were studied. The effect of fibre loading and fibre treatment with varying sodium hydroxide (NaOH)concentration on the composite properties was investigated...
9. FURFURAL PRODUCTION FROM MICROALGAE
Abstract
This research focused on the production of furfural from microalgae biomass and optimizing the process parameters using Response Surface Methodology (RSM). Furfural production was carried out by hydrolysis of Pentosans to Pentoses where Pentosans in hemicelluloses is hydrolyzed...
10. ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF METHANOL EXTRACT AND FRACTIONS OF LAGGERA AURITA LINN F (COMPOSITAE) IN MICE AND RATS
ABSTRACT
The plant Laggera aurita is an annual or biennial herb of widespread in dry waste places from across Senegal to Southern Nigeria. The plant has been reportedly used for medicinal purposes including treatment of rheumatic pain, healing of cuts and bruises, and as a last resort t...
11. ANALGESIC AND ANTI-INFLAMMATORY STUDIES ON METHANOL ROOT EXTRACT OF ANDROPOGON GAYANUS KUNTH (POACEAE) IN MICE AND RATS
ABSTRACT
The plant Andropogon gayanus is employed in herbal medicine for the treatment of various disease conditions. The dried root of the plant is soaked in milk and taken for the treatment of postpartum pain and bronchitis in North-west Nigeria. In this study the methanol root extrac...
12. ANALGESIC, ANTI-INFLAMMATORY AND OTHER PHARMACOLOGICAL ACTIVITIES OF METHANOL LEAF EXTRACT OF OLAX SUBSCORPIOIDEA OLIV (OLACACEAE) IN LABORATORY ANIMALS
ABSTRACT
Synthetic analgesic and anti-inflammatory drugs have major side effects such as constipation, nausea and vomiting, sedation and mental clouding, etc.,which have significantly limited their use.There is therefore, an intensification of search for newer analgesic and anti-inflamm...
13. ANALGESIC, ANTI-INFLAMMATORY AND TOXICITY STUDIES ON METHANOLIC LEAF EXTRACT OF ROTHMANNIA LONGIFLORA SALISB (RUBIACEAE) IN RATS AND MICE
ABSTRACT
The herbalists in several African Countries have used Rothmannia longiflora decoctions as febrifugal and analgesic agent. The present study examined the analgesic, anti-inflammatory and toxicological profile of the methanolic extract of the plant in experimental animals. The pr...
14. ANTI-DIARRHOEAL AND SUBCHRONIC TOXICITY STUDIES ON METHANOL STEM BARK EXTRACT OF IRIVINGIA WOMBOLU VERMOESEN (IRVINGIACEAE) IN LABORATORY ANIMALS
Abstract
Irvingia wombolu is one of the herbal plants used as food for its nutritional values. It is also used as medicinal plant in the south-south and south-eastern part of Nigeria for the management of diarrhoea and other ailments. Although these medicinal plants are believed to be h...
15. ANTICONVULSANT AND SUB-CHRONIC TOXICITY STUDIES OF THE METHANOL LEAF EXTRACT OF DIOSPYROS MESPILIFORMIS HOCHST (EBENACEAE) IN LABORATORY ANIMALS
ABSTRACT
Diospyros mespiliformis hochst (Ebenaceae) known in English as ebony is a plant that is found throughout West Africa. The Plant was reported to have wide ethnomedical application notably in fever, whooping cough, wounds, pneumonia, syphilis, leprosy and epilepsy among others. T...
16. ANTICONVULSANT STUDIES OF THE METHANOL EXTRACT AND FRACTIONS OF CASSIA SIAMEA LAM. (FABACEAE) IN MICE AND CHICKS
ABSTRACT
Cassia siamea is a shrub belonging to the Fabaceae family, native of Southeast Asia. The plant is commonly used in traditional medicine to treat hypertension, malaria and diabetes. Due to the easy cultivation of the plant, its widespread and also remarkable biological activitie...
17. ANTICONVULSANT STUDIES ON METHANOL LEAF EXTRACT OF LAGGERAAURITA LINN.F.IN LABORATORY ANIMALS
ABSTRACT
LaggeraauritaLinn. belongs to the family of Asteraceae. It is an annual herb which is found growing as weeds in Nigeria and spread throughout the sub-Saharan Africa. In Nigeria, Laggeraaurita is used asa remedy for pediatric malaria and in the management of epilepsy in Niger st...
18. ANTIDIARRHOAEL EFFECT OF METHANOL STEM BARK EXTRACT OF HYMENOCARDIA ACIDA (EUPHOBIACEAE) IN LABORATORY ANIMALS
Abstract
The objective of the present study was to evaluate the antidiarrheal activity of the methanol stem bark extract of Hymenocardia acida in some laboratory animals. They methanol stem bark extract of Hymenocardia acida (MEHA) was prepared from the freshly collected stem bark of th...
19. DESIGN, SYNTHESIS, ANTIMALARIAL EVALUATION AND COMPUTATIONAL STUDIES OF SOME CHALCONE DERIVATIVES
ABSTRACT
Inspired by the previous findings on the structural requirements needed for good antimalarial activity by chalcones against Plasmodium proteases, seventeen chalcone derivatives were designed and synthesized using Claisen-Schmidt condensation of appropriate aldehydes and methyl...
20. ANTIDIARRHOEAL AND TOXICITY STUDIES ON METHANOL LEAF EXTRACT OF COMBRETUM HYPOPILINUM DIELS (COMBRETACEAE) IN MICE AND RATS
ABSTRACT
The plant Combretum hypopilinum has been used in traditional medicine to treat diarrhoea and other gastrointestinal diseases. This study aimed to investigate the antidiarrhoeal activity and toxicity profile of the methanol leaf extract of Combretum hypopilinum (MECH) in mice an...
21. BEHAVIOURAL AND ANTICONVULSANT EFFECTS OF METHANOL EXTRACT OF FICUS VALLIS CHOUDAE (MORACEAE) STEM BARK
ABSTRACT
Ficus vallis choudae is a plant widely spread in tropical Africa including Nigeria. It is said to be of value in ethnomedicine especially in the treatment of jaundice, gastrointestinal problems, giddiness and epilepsy. The anticonvulsant activity of methanol stem bark extract o...
22. ANXIOLYTIC PROPERTIES OF MITRACARPUS VILLOSUS (SW) DC.LEAF EXTRACTS IN MICE AND RATS
ABSTRACT
The leaf of Mitracarpusvillosus (Sw.) DC. (Rubiaceae) is used in West African folk medicine for the management of a plethora of stress-related diseases including headaches and toothaches. In this study, preliminary phytochemical analysis of the ethylacetateleaf extract of Mitra...
23. COMPARATIVE PHARMACOGNOSTIC AND BIOLOGICAL STUDIES ON THE LEAVES OF VERNONIA AMYGDALINA DEL. AND VERNONIA KOTSCHYANA SCH. BIP. (ASTERACEAE)
ABSTRACT
Vernonia amygdalina Del. and V. kotschyana Sch. Bip. (Asteraceae) are respectively shrub or tree and annual herb found commonly in tropical and subtropical countries. They are employed in ethno-medicine in the treatment of many ailments namely stomach ache, gingivitis, rheumati...
24. EFFECTS OF ACUTE EXPOSURE TO GENERATOR EXHAUST FUMES ON LEARNING, MEMORY AND MOTOR COORDINATION IN ALBINO MICE
ABSTRACT
The study involved assessment of the effects produced by exposure of mice to generator exhaust fumes on the learning, memory and motor coordination. Carbon monoxide (CO) which is produced from combustion of any carbonaceous substance is among the toxic contents and was studied...
25. HYPOTENSIVE ACTIVITY AND TOXICOLOGICAL PROFILE OF STEM BARK EXTRACT OF SYZYGIUM GUINEENSE (Willd, D.C. Myrtaceae) IN LABORATORY ANIMALS
ABSTRACT
Hypertension of unknown cause is called essential or primary hypertension while hypertension of a known cause is called secondary hypertension. Hypertension is called a silent killer because it is usually asymptomatic. It is a global problem affecting 1 in 3 adults in the Unite...
26. PHARMACOGNOSTIC AND ANTICONVULSANT STUDIES ON GLOSSONEMA BOVEANUM DECNE (APOCYNACEAE)
ABSTRACT
Glossonema boveanum Decne is a hairy canescent perennial herb belonging to the Apocynaceae. Traditionally, the powdered whole plant is use for the treatment of many illnesses including epilepsy. This study is aimed at establishing some of the pharmacognostic features of the pow...
27. PHARMACOGNOSTIC AND ANTIVENIN STUDIES ON LEAVES OF SECURINEGA VIROSA (ROXB EX WILLD) BAILL
ABSTRACT
7 Securinega virosa (Roxb ex Willd) Baill (Euphorbiaceae) is a small, deciduous, graceful shrub that is widely distributed in Africa. It is used to treat snakebites, syphilis, rheumatism and malaria. Plant based medicines are limited in use because of inadequate standardization...
28. PHARMACOGNOSTIC, ANALGESIC AND ANTI-INFLAMMATORY STUDIES ON THE LEAVES OF MICROTRICHIA PEROTITII DC (ASTERACEAE)
ABSTRACT
Microtrichia perotitii DC Asteraceae (Compositeae) is an herb found in the tropical countries. Ethno-medicinally, it is mainly used for the treatment of pain related diseases such as toothaches, cuts and burns and few ailments like rashes, rheumatism, jaundice, stomachaches and...
29. PHYTOCHEMICAL AND ANTIVENOM STUDIES ON THE STEM BARK OF ALBIZIA CHEVALIERI HAMS (MIMOSACEAE) ON NAJA NIGRICOLLIS BROADLEY ENVENOMATED MICE
ABSTRACT
Albizia chevalieri Hams (Mimosaceae), mostly found in the Northern Sahel Savannah region of Nigeria as well as in Nigér and Senegal is a tree of the acacia type with a long list of folklore therapeutic claims which include its use as purgative, taenicidal, cough remedy,...
30. PHYTOCHEMICAL AND BIOLOGICAL STUDIES OF ETHANOL EXTRACT OF CHROZOPHORA SENEGALENSIS (LAM) A. JUS
Abstract
The ethanol extract of root of Chrozophora senegalensis use in ethanomedicine to treat diarrhea, rheumatism, taeniasis, stomach ache, inflammation and veneral diseases was subjected to Phytochemical and Biological studies. Phytochemical analysis was carried out using standard p...
31. PHYTOCHEMICAL AND SOME BIOLOGICAL STUDIES OF THE METHANOL EXTRACT OF THE AERIAL PARTS OF AMPELOCISSUS GRANTII(BAKER) PLANCH. (VITACEAE)
ABSTRACT
The plant Ampelocissus grantii is used in traditional medicinal practice in the treatment of cough, wounds, venereal infections and other ailments.Phytochemical examination of the methanol extract of the aerial parts of Ampelocissus grantii (Baker) Planch (Family, Vitaceae) rev...
32. PHYTOCHEMICAL AND SOME PHARMACOLOGICAL STUDIES OF THE AERIAL PART OF ALYSICARPUS OVALIFOLIUS Schumach & Thonn FAMILY: FABACEAE
ABSTRACT
Alysicarpus ovalifolius (Schum.&Thonn) Family: Fabaceae is a protein rich fodder plant that is widely distributed across Africa, Asia and Australia and medicinally used to treat cough and wounds. Recently, it has been reported to be used in the Northern part of Nigeria as t...
33. PHYTOCHEMICAL AND SOME PHARMACOLOGICAL STUDIES ON THE LEAF EXTRACT OF ZIZIPHUS MUCRONATA WILLD. (RHAMNACEAE)
ABSTRACT
Chronic inflammation has been implicated in most non-communicable/chronic degenerative diseases including age-related cancers. Ziziphus mucronata, a plant used in ethnomedicine to treat different painful and inflammatory conditions, was subjected to phytochemical investigation...
34. SOME NEUROPHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF THE ETHANOLIC LEAF EXTRACT OF CUSSONIA BARTERI SEEMAN (ARALIACEAE) IN LABORATORY ANIMALS
ABSTRACT
Cussonia barteri is used in traditional medicinefor the management of convulsion and epilepsy, especially in children in Ghana and Nigeria. Literature survey revealed that the safety and efficacy of such important medicinal plant have not been scientifically validated. In the p...
35. SURFACE ACTIVITY AND RELEASE PROPERTIES OF SOME TROPICAL GUMS IN ARTEMETHER AND ARTESUNATE SODIUM TABLET FORMULATIONS
ABSTRACT
Plant gums are natural polymers with low toxicity, high biodegradability and high compatibility with drugs making them useful as pharmaceutical excipients in solid, semi-solid and liquid formulations. This work was aimed at evaluating the surface activity and release properties...
36. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES
Abstract
The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic tech...
37. TOXICOLOGICAL, ANTIPYRETIC, ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF METHANOL LEAF EXTRACT OF DALBERGIA SAXATILIS HOOK. F (FABACEAE) IN RATS AND MICE
ABSTRACT
The decoction of the leaves of Dalbegia saxatilis is used in Traditional Medicine for various ailments such as cough, small pox, skin lesions, bronchial ailments and toothache. The study was aimed at establishing a safety profile, evaluating phytochemical constituents and some...
38. EFFECTS OF DETOXIFICATION ON SOME PHARMACOLOGICAL PROPERTIES OF JATROPHA CURCAS LINN. (EUPHORBIACEAE) SEED OIL IN LABORATORY ANIMALS
Abstract
Jatropha curcas seed oil is a known energy source in biodiesel which but for its toxicity, also has potential of being used as food and in the pharmaceutical / cosmetic industries. This study was designed to detoxify solvent and mechanically extracted J. curcas oils and to asce...
39. EVALUATION OF THE GASTROPROTECTIVE AND SUB-CHRONIC TOXICITY OF METHANOL STEM BARK EXTRACT OF XIMENIA AMERICANA LINN (OLACACEAE) IN MALE WISTAR RATS
Abstract
Ximenia americana is a plant used traditionally in northern parts of Nigeria for treatment of leprotic ulcers and mouth ulcers in addition to other medicinal uses. It contains flavanoids, saponins, tannins among others that has been reported to possess gastroprotective potentia...
40. MEDICINAL PLANTS USED IN THE MANAGEMENT OF DEPRESSIVE ILLNESSES: ANTIDEPRESSANT ACTIVITY OF METHANOL STEM BARK EXTRACT OF ADANSONIA DIGITATA L. IN MICE
ABSTRACT
Depression is a heterogeneous mood disorder that has been treated with a number of synthetic drugs. These drugs have adverse effects and delayed onset of action that compromise their therapeutic benefits. This makes it worthwhile to search for new antidepressant agents with pro...
41. PHARMACOGNOSTIC AND ANTI-ULCER EVALUATIONS OF CASSIA SIEBERIANA D.C. (FABACEAE) ROOT
ABSTRACT
Cassia sieberiana D.C. (Fabaceae) though widely used in traditional medicine as an analgesic in dysmenorrhoea, ulcer and general body pains, there is no published report on it standardization. Pharmacognostic evaluation of the root will therefore assist in standardization for q...
42. PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF THE METHANOL EXTRACT OF ACACIA ATAXACANTHA LEAF D.C. (LEGUMINOSAE) IN MICE AND RATS
ABSTRACT
Acacia ataxacantha is used in traditional medicine for management of pain and inflammation. Literature survey revealed that the safety and efficacy of such uses have not been scientifically validated. The present study was designed to study the pharmacological and toxicological...
43. PHYTOCHEMICAL AND ANTICONVULSANT STUDIES OF METHANOL LEAF EXTRACT OF HYMENOCARDIA ACIDA, TUL (EUPHORBIACEAE)
ABSTRACT
The research was on the phytochemical and anticonvulsant studies of methanol leafextract of Hymenocardia acida, Tul, (Euphorbiaceae) used inNorthern Nigeria for the treatment of headache, rheumatic pain, sickle cell crisis, malaria, epilepsy and cancer. The preliminary phytoche...
44. PHYTOCHEMICAL AND ANTIVENOM EVALUATIONS OF METHANOL LEAF EXTRACT OF CLERODENDRUM CAPITATUM (WILLD) SCHUM. AND THONN. (VERBENACEAE)
ABSTRACT
Clerodendrum capitatum (Willd) Schumach and Thonn. is a common medicinal plant found mainly in the tropical and sub-tropical regions of the world where it is used in traditional medicine for the treatment of various conditions including erectile dysfunction, wounds, diabetes me...
45. PHYTOCHEMICAL SCREENING AND ANTICONVULSANT STUDIES OF ETHYL ACETATE FRACTION OF ETHANOLIC EXTRACT OF THE LEAVES OF GLOBIMETULA BRAUNII (LORANTHACEAE) PARASITING ON PILIOSTIGMA THONINGII (FABACEAE)
ABSTRACT
The ethyl acetate soluble fraction of ethanol extract of leaves of Globimetula braunii, a plant used in ethnomedicine for the treatment of epilepsy and diabetes among other ailments, was subjected to phytochemical and anticonvulsant screening. The phytochemical techniques emplo...
46. PHYTOCHEMICAL, ANTIOXIDANT AND ANTISNAKE VENOM STUDIES OF THE METHANOL EXTRACT OF THE ROOT BARK OF PHYLLANTHUS MUELLERIANUS (KUNTZE) EXCELL
ABSTRACT
Phyllanthus muellerianus is distributed in secondary forests from Guinea-Bissau, Mali, West Cameroons and other parts of tropical Africa. It is a shrub or climber deciduous and occasionally arborescent. The root bark of this plant was extracted by maceration using methanol. The...
47. SOME CARDIOVASCULAR ACTIVITIES OF THE AQUEOUS LEAF EXTRACT OF CROTON ZAMBESICUS LINN (EUPHORBIACEAE) IN LABORATORY ANIMALS
Abstract
Croton zambesicus Linn (Euphorbiaceae) is a highly valued medicinal plant in Nigeria and West African sub-region. It is used by traditional medicine practitioners in the treatment of various ailments including hypertension. This study aims to determine some cardiovascular activ...
48. SOME NEUROPHARMACOLOGICAL STUDIES ON ETHANOL EXTRACT AND FRACTIONS OF TAPINANTHUS GLOBIFERUS A. RICH MISTLETOE ON VITELLARIA PARADOXA HOST IN LABORATORY ANIMALS
ABSTRACT
Tapinanthus globiferus is a semi-parasite mistletoe which grows on branches of large number of trees including Vitellaria paradoxa. It used locally in the management of insomnia, epilepsy, anxiety, headaches and hypertension. This study evaluated the toxicity and neuropharmacol...
49. EFFECT OF AQUEOUS ETHANOL LEAF EXTRACT OF COMBRETUM MICRANTHUM G. DON (COMBRETACEAE) ON SOME INDUCED SYSTEMIC INFLAMMATORY IMMUNE RESPONSE SYNDROMES IN MICE AND RATS
Abstract
The cellular immunity is often suppressed by infection, disease conditions and drug medication that are in continous association with mankind. Combretum micranthum is a plant known for its antioxidant, antimicrobial, anti-inflammatory and various other properties of immune boos...
50. EFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICE
ABSTRACT
Malaria is the 2nd leading cause of death from infectious diseases in Africa, after HIV/AIDS. It is a major public health problem in Nigeria where it accounts for most cases of hospital visits and deaths than any other country in the world. This study evaluated the effects of c...
