ABSTRACT
The increasing use of artemether-lumefantrine combination as an effective treatment for resistant malaria demands the need for analytical methods for the quality control of these drugs in tablets and suspensions. Though some UV Spectrophotometric methods have been developed for quantification of artemether in various biological fluids and formulations, they require strainous heating conditions which is a limitation. This limitation coupled with non-availability of HPLC hence the need to develop and validate a simple method for the quantification of artemether in peadiatric suspensions. In this work, we report the method developed by reacting artemether solution in methanol with concentrated HCl for 30 minutes to obtain an α,β-unsaturated ketone which was scanned with a UV Spectrophotometer. The method developed obeyed Beers law in the range 20 – 120 µg/ml, slope (y); 0.01 0, intercept (x) 0.193, correlation coefficient (r) 0.9987, λmax 260 nm, precision (% CV); 2, Accuracy (% Er); 2.67 and a recovery of 97%. The detection and quantification Limit (µg/ml) are 0.14 and 0.58 respectively. The developed method was successfully applied in the assay of five brands of artemether-lumefantrine suspensions with 98-101.6% content, and comparism of the means of the assay results of the method and the IP (2008) method showed no statistically significant difference (P<0.05). Stability studies of the standard artemether suspension prepared and five different brands of artemether/lumefantrine powders for suspension was carried out by extracting artemether with methanol from the suspensions and analyzing it using the developed method. The content of artemether over 14 days study period ranged between 98.5-102% and this showed that the suspensions are stable under ambient conditions for upto 14 days after reconstitution with bottled table water. The results of the study suggested that the developed method could be used interchangeably in viii analysis, and that co-formulation of artemether with lumefantrine has no effect on the stability of artemether.
ABSTRACT
Integrating technology into the educational sector is progressively influenced by different multicultural settings across the wo...
ABSTRACT
The consumption of ready-to-eat (RTE) game meat and fresh produce has increased and it serves as a very important part of human...
Abstract
This study examined the influence of parental Separation on Academic Achievement of Secondary School Student in Lagos Educationa...
ABSTRACT
This study was carried out to evaluate E-Mobilization and 2023 general election. The impact of...
ABSTRACT
This study was carried out to examine the influence of class size on teaching and learni...
ABSTRACT
In this study, our focus was to examine feel good advertising and its effect on consumer...
Abstract
This study is on economic operation and integration in West Africa (1999-2010). The total population for...
Background to the Study.
Early childhood education is largely a post-colonial development. The semblanc...
Background of the study
Flipped learning is a type of blended-learning approach of instruction. It prom...
OBJECTIVES OF THE STUDY
The major objective of the study is to design and implement an online campus opinion poll system...