SPECTROPHOTOMETRIC DETERMINATION AND STABILITY STUDIES OF ARTEMETHER IN ARTEMETHER-LUMEFANTRINE SUSPENSIONS MARKETTED IN NIGERIA
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The increasing use of artemether-lumefantrine combination as an effective treatment for resistant malaria demands the need for analytical methods for the quality control of these drugs in tablets and suspensions. Though some UV Spectrophotometric methods have been developed for quantification of artemether in various biological fluids and formulations, they require strainous heating conditions which is a limitation. This limitation coupled with non-availability of HPLC hence the need to develop and validate a simple method for the quantification of artemether in peadiatric suspensions. In this work, we report the method developed by reacting artemether solution in methanol with concentrated HCl for 30 minutes to obtain an α,β-unsaturated ketone which was scanned with a UV Spectrophotometer. The method developed obeyed Beers law in the range 20 – 120 µg/ml, slope (y); 0.01 0, intercept (x) 0.193, correlation coefficient (r) 0.9987, λmax 260 nm, precision (% CV); 2, Accuracy (% Er); 2.67 and a recovery of 97%. The detection and quantification Limit (µg/ml) are 0.14 and 0.58 respectively. The developed method was successfully applied in the assay of five brands of artemether-lumefantrine suspensions with 98-101.6% content, and comparism of the means of the assay results of the method and the IP (2008) method showed no statistically significant difference (P<0.05). Stability studies of the standard artemether suspension prepared and five different brands of artemether/lumefantrine powders for suspension was carried out by extracting artemether with methanol from the suspensions and analyzing it using the developed method. The content of artemether over 14 days study period ranged between 98.5-102% and this showed that the suspensions are stable under ambient conditions for upto 14 days after reconstitution with bottled table water. The results of the study suggested that the developed method could be used interchangeably in viii analysis, and that co-formulation of artemether with lumefantrine has no effect on the stability of artemether.
Related Project Materials
THE IMPACT OF COST ACCOUNTING ON LEAN PRODUCTION AND JUST-IN-TIME INVENTORY
Abstract: THE IMPACT OF COST ACCOUNTING ON LEAN PRODUCTION AND JUST-IN-TIME INVENTORY
This research explores the impact of cost accountin...
THE IMPLICATION OF NIGERIA VALUE ADDED TAX (VAT) ON THE PAYERS
ABSTRACT
This study was carried out to examine the the implication of Nigeria value added tax (vat...
SPATIO-TEMPORAL VARIATION OF HEAVY METAL CONCENTRATIONS IN WATER, SEDIMENT AND IN SELECTED FISH SPECIES IN SHIRORO LAKE, NIGER STATE, NIGERIA.
ABSTRACT
Anthropogenic activities contribute the most to heavy metals pollution of water bodies around the world. This study was conducte...
THE ROLE OF ACCOUNTANT IN THE ECONOMIC DEVELOPMENT OF organization (A STUDY OF NIGERIAN BOTTLING COMPANY ONITSHA)
ABSTRACT
The main purpose of this project is to find out the Role of accountants in the economic development of Nigeria...
THE USE OF NIGERIAN PIDGIN ENGLISH IN IPODO AND ALADE MARKETS
ABSTRACT
This essay is going to examine the use or Nigerian Pidgin in Ipodo and Alade markets. Chapter one treats the background study, h...
Utilization Of School Library Resources By Secondary School Students IN ONITSHA (A COMPARATIVE STUDY OF CHRIST THE KING COLLEGE AND DENNIS MEMORIAL GRAMMAR SCHOOL ONITSHA)
ABSTRACT
The research is concerned with the study of the utilization of school library resources by seconda...
THE STUDY ON THE INFLUENCE OF POLITICAL ADVERTISING ON VOTING BEHAVIOUR OF RESIDENTS OF RURAL COMMUNITY
ABSTRACT
World over, political aspirants adopt the use of diverse campaign strategies such as political advertising in o...
MULTI-LEVEL INTRUSION DETECTION AND LOG MANAGEMENT SYSTEM IN CLOUD COMPUTING
INTRODUCTION
As Green IT has been issued, many companies have started to find ways to decrease IT cost and overcome econ...
ANALYSIS OF POVERTY STATUS OF FOREST DWELLERS IN COASTAL COMMUNITIES IN ONDO STATE
ABSTRACT
This study analyzed poverty status of forest dwellers in coastal communities of Ondo State, Ni...
MORAL JUSTIFICATION OF THE STATE INTERFERENCE WITH THE RIGHTS AND LIBERTIES OF THE CITIZENS
ABSTRACT
In the history of political philosophy there have been different views as to what relationship should exists be...
