0704-883-0675     |      dataprojectng@gmail.com

EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

Starch is a major carbohydrate, easily extractable from various sources like cassava, maize, potato etc which find wide application in various food and Pharmaceutical industries. There has been a lot of attempt to modify this highly flexible polymer with the aim of extending and enhancing its applications. Native cassava starch (NCS) was extracted from the tubers of freshly harvested cassava. Enzyme- hydrolysed starch (EHS) was produced from Native cassava starch (NCS) using enzymatic hydrolysis method with α – amylase as the enzyme. The physicochemical characterization for NCS and EHS was conducted using standard methods, such as flow rate, angle of repose, mean particle size, moisture content, Carr‟s index, Hausner‟s ratio, ash content, swelling power, pH, bulk and tapped densities. Chloroquine tablets were formulated by wet granulation method and direct compression using EHS, MCC, MS and NCS as binders at different concentrations of 2.5, 5, 7.5 and 10 %w/v. The tablet characteristics were evaluated and compared with that of MCC and maize starch. The mechanical properties using crushing strength and friability for NCS and EHS were carried out. The crushing strength increased with increase in binder concentration while friability decreased. The disintegration time also increased with increase in binder concentration. The disintegration and dissolution profile of the tablets were studied and these were much faster for EHS tablets when compared to that of PVP. Using the direct compression method, crushing strength was found to increase with increase in binary mixture of MCC and the friability increases with increase in the viii proportion of EHS. The Disintegration time was above 60 min., the tablet continued to swell, absorbing more water without disintegrating for the period of the study. The study found out that EHS is comparable to standard starches and can be used as a binder in wet granulation and direct compression method in Pharmaceutical industries to produce the tablets.





Related Project Materials

FACTORS AFFECTING THE IMPLEMENTATION OF IMMUNIZATION

ABSTRACT

This study examined the factors affecting the implementation of immunization. This study investigated the facto...

Read more
DETERMINANT OF TAX COMPLIANCE AMONG SMES

Abstract

Tax is an important stream of revenue for government’s development projects. The importance of tax syste...

Read more
IMPACT OF SOCIAL CAPITAL ON PERFORMANCE OF HOSPITALITY INDUSTRY IN MINNA METROPOLIS, NIGER STATE, NIGERIA

ABSTRACT

Hospitality industry, especially hotel business is declining in Nigeria due to their inability to infuse the culture of social r...

Read more
THE INFLUENCE OF TRANSPORTATION MANAGEMENT ON LOGISTICS COSTS

Abstract: THE INFLUENCE OF TRANSPORTATION MANAGEMENT ON LOGISTICS COSTS

This study examines the influence of transportation management on...

Read more
THE IMPACT OF ONLINE MARKETING ON THE PERFORMANCE OF SMALL AND MEDIUM SCALE ENTERPRISES (SMES) IN NIGERIA

ABSTRACT

This study was carried out on the impact of online marketing on the performance of small and m...

Read more
UNITED NATIONS SECURITY COUNCIL AND GLOBAL CRISIS MANAGEMENT: A CASE STUDY OF THE UNITED STATES INVASION OF IRAQ, 1991-2008

INTRODUCTION

Evaluation of the Iraq conflict cannot be finished until the roles performed by two key actors—the Un...

Read more
THE INFLUENCE OF ALCOHOL ON HEALTH BEHAVIOR OF YOUTH IN EGOR LOCAL GOVERNMENT

Abstract

Alcohol consumption among different ethnic groups in Nigeria has a long history, especially among those groups...

Read more
DOMESTIC VIOLENCE AGAINST WOMEN IN NIGERIA EXPERIENCE

​​​​​​​Background of the study

Apart from CEDAW and other international instruments which Nigeria is signatory to laws t...

Read more
EXAMINING THE ROLE OF EARLY CHILDHOOD EDUCATION IN ENHANCING CULTURAL AWARENESS

ABSTRACT: This study examining the Role of Early Childhood Education in Enhancing Cultural Awareness. The ob...

Read more
3D First Person Shooter PC Game

ABSTRACT

Monsters Within is a fun 3D FPS horror survival game on the Windows platform that demands its players to have fast reflexes, qui...

Read more
Share this page with your friends




whatsapp