1. AWARENESS OF THE USE OF ENVIRONMENTAL MANAGEMENT IN THE CONTROL AND PREVENTION OF MALARIA
Background To the study
The vast majority of malaria deaths occur in Africa, south of the Sahara, where malaria also presents major obstacles to social and economic development. Malaria has been estimated to cost Africa more than US$ 12 billion every ye...
2. ANTIMALARIAL SUSCEPTIBILITY AND DRUG RESISTANCE CHARACTERIZATION STUDIES OF PLASMODIUM SPECIES ISOLATES FROM PATIENTS IN NIGERIA
ABSTRACT
About half of Nigerian population experience at least one episode of malaria per year, resulting in high morbidity and mortality and loss of economic value. Retrospective study of the profile of malarial patients and the antimalarial drugs prescribed at Umaru Musa Yaradua memor...
3. STUDY ON THE EFFICACY AND SAFETY OF ARTEMETHER/LUMEFANTRINE IN THE TREATMENT OF UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA AMONGST CHILDREN IN NIGERIA
ABSTRACT
Globally, malaria is a major health concern because it causes high morbidity and mortality particularly in children under 5 years because of their low immunity. The development of resistance to chloroquine and sulphodoxine/pyrimethamine in many parts of the world has further wo...
4. EFFECTS OF ANTIMALARIAL DRUGS ON OESTROUS CYCLE AND UTERINE CONTRACTILITY IN RATS
ABSTRACT
Malaria is increasingly a health burden globally with children under the age of 5 and pregnant women being the most vulnerable. Several antimalarials are available in the market today however; the safety data in pregnancy is inadequate especially the first trimester of pregnanc...
5. EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS
ABSTRACT
Starch is a major carbohydrate, easily extractable from various sources like cassava, maize, potato etc which find wide application in various food and Pharmaceutical industries. There has been a lot of attempt to modify this highly flexible polymer with the aim of extending an...
6. IN VITROANTIMALARIAL SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM ISOLATES FROM PATIENTS ATTENDING A HEALTH FACILITY IN NIGERIA
ABSTRACT
The continous emergence and spread of resistant strains of Plasmodium falciparumisolates to single and combined antimalarial drug has resulted to increase in mortality rate associated with the disease, especially in the African Continent as a whole and Nigeria in particular whe...
7. PHYTOCHEMICAL AND ANTIMALARIAL STUDIES OF THE LEAVES OF UVARIA CHAMAE P.BEAUV. (ANNONACEAE)
ABSTRACT
Uvaria chamae P.Beauv. belong to the Annonaceae family of flowering plants. It is distributed in the savannah and secondary forest. The plant is used in ethnomedicine for the treatment of malaria, inflammation, gonorrhea, dysentery; pile and fever. The ethyl alcohol leaves extr...
8. THE EFFECT OF VITAMIN C ON PHARMACOKINETIC PARAMETERS OF CHLOROQUINE IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
This study was undertaken to compare the effect of vitamin C on the pharmacokinetics of chloroquine using human volunteers. Quality control studies for both chloroquine and vitamin C; identification test, assay, weight variation, friability, disintegration time and dissolution...
9. FORMULATION STUDIES OF ACACIA SIEBERIANA GUM IN CHOROQUINE AND METRONIDAZOLE MATRIX TABLETS
ABSTRACT
The crude plant gum from African Acacia sieberiana was purified and investigated for use as a matrix excipient for chloroquine phosphate and metronidazole tablet formulations. The chromatographic analysis of the acid hydrolysed gum revealed the presence of rhamnose, galactose,...
10. THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS
ABSTRACT
The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official me...
11. ANTITRYPANOSOMAL EFFECT OF CRUDE SCORPION VENOM EXTRACT IN TRYPANOSOMA EVANSI INFECTED SWISS ALBINO RATS
ABSTRACT Despite the control measures against trypanosomiasis over the past few decades, the disease still contributes to the current economic losses and socio-political crises in the sub-Saharan Africa. The recent interest of chemotherapists in aggressive search for novel antitrypanosomal drug a...
12. EVALUATION OF BIOACTIVE METABOLITE CONTENTS, MOSQUITO LARVICIDAL AND ANTI-PLASMODIAL ACTIVITIES OF EXTRACTS OF THE SPIDER Neoscona adianta
ABSTRACT
In spite of the extensive control efforts, over the years, mosquito still transmit serious human diseases, cause millions of deaths every year and the development of resistance to chemical insecticides resulting in rebounding vectorial capacity. This situation is aggravated wit...
13. IN VIVO EFFICACY OF METHANOLIC EXTRACTS OF ROOT AND LEAF OF Morinda lucida IN Plasmodium berghei - INFECTED MICE
ABSTRACT
Therapeutic effects of the methanolic root extract and a combination of leaf and root extracts of Morinda lucida were evaluated for antiplasmodial activities. The phytochemical screening of the methanolic root extract showed the presence of saponins, flavonoids, alkaloids, phen...
14. EVALUATION OF SOME NATURAL AND SYNTHETIC PRODUCTS AGAINST AFRICAN TRYPANOSOMIASIS
ABSTRACT
The chemotherapy of African trypanosomiasis, a fatal protozoal disease of man and animals is beset with many problems including a limited repertoire of expensive compounds, drug toxicity and resistance and protracted treatment protocols. In order to improve chemotherapy, some n...
