DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF RISPERIDONE IN PURE AND TABLET DOSAGE FORMS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Two simple, sensitive, accurate and extraction-free spectrophotometric methods were developed and described for the determination of risperidone in pure and in tablet dosage forms. The methods are based on the formation of ion-pair complex between risperidone and the dyes bromocresol green in method A and thymol blue in method B at room temperature to form yellow coloured products having absorption maxima at 414 nm and 404 nm respectively. The composition of the ion-pairs was established by Job‟s method and it was found to be 1:1 for both methods. Different variables affecting the reaction conditions such as diluting solvents, concentration of dye, reaction time were studied and optimized. Under the optimal conditions, linear relationship with good correlation coefficients (0.994 and 0.995 for methods A and B respectively) was found between absorbance and the concentrations of risperidone in the range of 2-20 µg/ml and 20-40 µg/ml respectively. The assay limits of detection (LOD) and limits of quantification (LOQ) were 1.27 and 3.84 µg/ml for method A and 7.00 and 21.15 µg/ml for method B. The precision of both methods did not exceed 15% likewise the percentage relative error was within the accepted range of 1-5%. No interference could be observed from the excipients commonly present in tablet or liquid dosage forms. The methods developed have been validated and there is no significant difference (P 0.05) between the methods and the reference (BP) method. The methods can be successfully applied for the analysis of risperidone in pure and tablet dosage forms.
Related Project Materials
The Effect of Shift Patterns on the Cardiovascular Health of Nurses in Federal Teaching Hospital, Ido-Ekiti
Background of the Study
Shift work is an integral part of the nursing profession, ensuring continuous...
The Influence of Digital Media on Students’ Unionism in Jimeta Local Government Area, Adamawa State
Chapter One: Introduction
The Role of Event Planners in Shaping Cultural Perceptions in Argungu Local Government Area, Kebbi State
Chapter One: Introduction
1.1 Background of the Study
Event planners play a critical role in shaping cultural perceptions by de...
An Evaluation of Behavioral Economics Approaches in Understanding Consumer Choices in Nigeria
Background of the Study
Behavioral economics integrates insights from psychology and economics to explain how individuals m...
An Investigation of the Role of Customer Experience in Brand Loyalty: A Case Study of Coca-Cola Nigeria in Niger State
Background of the Study
Customer experience (CX) encompasses all the interactions a customer has with a brand, from prod...
The Effect of GDP Trends on FDI Inflows in Nigeria
Background of the Study
Foreign Direct Investment (FDI) plays a pivotal role in technology transfer, job creation, and ove...
An investigation of computational semantic analysis in Nigerian Pidgin social media discourse
Background of the Study
Computational semantic analysis has emerged as an essential tool for understanding...
The effect of local government leadership on rural electrification in Jibia South Local Government Area, Katsina State
Chapter One: Introduction
1.1 Background of the Study
Rural electrification is an essential a...
An Evaluation of Business Expansion Strategies Among Women Entrepreneurs: A Case Study of Boutiques in Yobe State
Background of the Study
Women entrepreneurs in Nigeria play a significant role in the country's economic development, p...
A CRITICAL SURVEYOR OF ADVERTISING AS A DETERMINANT OF CUSTOMER PATRONAGE IN THE FAST FOOD INDUSTRY
ABSTRACT
This research study is generally intended to critically survey advertising as a determina...
