0704-883-0675     |      dataprojectng@gmail.com

SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

Abstract

The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic techniques. Compounds (A01-A15) were screened in mice against maximal electroshock (MES) and subcutaneous pentylene tetrazole (scPTZ) seizure models as well as the righting reflex test for neurological deficit. All the 15 compounds were active in the MES test with A04, A05, A07 and A13 being more potent than phenytoin. Compounds A05, A06 and A11-A15 were active in both MES and scPTZ seizures models and therefore have valproate-like activity. Compound A04 is the most potent (ED50 = 0.63mg/Kg) anti-MES compound ever reported in the literature while compound A13 is the most potent (MES ED50 = 3.25mg/Kg and scPTZ ED50 = 20.40mg/Kg) in the valproate class. The results of this work agrees with Unverferth et al (1998) and Shindikar et al (2006) proposed pharmacophores for anticonvulsants active at the voltage-dependent sodium channels. The compounds mentioned above are recommended for further studies.





Related Project Materials

THE EFFECT OF MANAGEMENT INFORMATION SYSTEM ON ORGANISATIONAL PERFORMANCE

ABSTRACT

This study was carried out on the effect of management information system on organisational performance using N...

Read more
THE EFFECT OF POVERTY ON THE ACADEMIC PERFORMANCE OF STUDENTS IN SOME SELECTED SECONDARY SCHOOLS

 

ABSTRACT

This research work was designed to find out the effect of poverty on the academic performa...

Read more
THE IMPACT OF CREDIT RISK ON BANK PERFORMANCE IN NIGERIA

Abstract

This study intends to examine the impact of credit risk on bank performance in Nigeria for the...

Read more
HERMENEUTICAL APPRAISAL OF LUKE 16-19-31 IN THE CONTEXT OF THE RICH-POOR DICHOTOMY IN IGBOLAND -NIGERIA

Background to the Study

The text of Luke 16:19-31, the parable of the rich man and Lazarus (Λάδα&rho...

Read more
ATTITUDE AND KNOWLEDGE OF NURSING MOTHERS TOWARDS IMMUNIZATION

STATEMENT OF RESEARCH PROBLEM

The impact of immunization on the reduction of childhood morbidity and mortality and the w...

Read more
THE IMPACT OF TECHNOLOGY ON GOVERNMENTAL ACCOUNTING PRACTICES

THE IMPACT OF TECHNOLOGY ON GOVERNMENTAL ACCOUNTING PRACTICES

Abstract

This research examines the impact of technology on gover...

Read more
DESIGN AND IMPLEMENTATION OF A CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM

3     BACKGROUND THE OF STUDY

Customer Relationship Management (CRM) system came into existence when...

Read more
THE ROLE OF CHARISMATIC LEADERSHIP IN MOTIVATING EMPLOYEES

THE ROLE OF CHARISMATIC LEADERSHIP IN MOTIVATING EMPLOYEES

This study explores the rol...

Read more
influence of home videos on the moral behavior of students of caritas university

Background of the study

Over the years world views have continually detected the moral disposition of the world’s people. This is t...

Read more
INFLUENCE OF FAMILY FACTORS ON ACADEMIC ACHIEVEMENT OF SECONDARY SCHOOL STUDENTS IN ENGLISH LANGUAGE (A CASE STUDY OF YAKURR LOCAL GOVERNMENT AREA OF CROSS RIVER STATE)

ABSTRACT

This study was carried out in order to determine the influence of family factors on the academic achievement of...

Read more
Share this page with your friends




whatsapp