1. ANTICONVULSANT AND SUB-CHRONIC TOXICITY STUDIES OF THE METHANOL LEAF EXTRACT OF DIOSPYROS MESPILIFORMIS HOCHST (EBENACEAE) IN LABORATORY ANIMALS
ABSTRACT
Diospyros mespiliformis hochst (Ebenaceae) known in English as ebony is a plant that is found throughout West Africa. The Plant was reported to have wide ethnomedical application notably in fever, whooping cough, wounds, pneumonia, syphilis, leprosy and epilepsy among others. T...
2. ANTICONVULSANT STUDIES OF THE METHANOL EXTRACT AND FRACTIONS OF CASSIA SIAMEA LAM. (FABACEAE) IN MICE AND CHICKS
ABSTRACT
Cassia siamea is a shrub belonging to the Fabaceae family, native of Southeast Asia. The plant is commonly used in traditional medicine to treat hypertension, malaria and diabetes. Due to the easy cultivation of the plant, its widespread and also remarkable biological activitie...
3. ANTICONVULSANT STUDIES OF THREE SYNTHESIZED DICHLOROSUBSTITUTED PHENYL PROPANAMIDES AND THEIR ACTION ON VOLTAGE-GATED SODIUM CHANNELS (Nav1.6)
Abstract
The field of antiepileptic drug development has become dynamic, affording many promising research opportunities. Continued efforts are being made in the development of antiepileptic drugs employing a range of strategies, including modification of the structures of existing drug...
4. ANTICONVULSANT STUDIES ON METHANOL LEAF EXTRACT OF LAGGERAAURITA LINN.F.IN LABORATORY ANIMALS
ABSTRACT
LaggeraauritaLinn. belongs to the family of Asteraceae. It is an annual herb which is found growing as weeds in Nigeria and spread throughout the sub-Saharan Africa. In Nigeria, Laggeraaurita is used asa remedy for pediatric malaria and in the management of epilepsy in Niger st...
5. BEHAVIOURAL AND ANTICONVULSANT EFFECTS OF METHANOL EXTRACT OF FICUS VALLIS CHOUDAE (MORACEAE) STEM BARK
ABSTRACT
Ficus vallis choudae is a plant widely spread in tropical Africa including Nigeria. It is said to be of value in ethnomedicine especially in the treatment of jaundice, gastrointestinal problems, giddiness and epilepsy. The anticonvulsant activity of methanol stem bark extract o...
6. PHARMACOGNOSTIC AND ANTICONVULSANT STUDIES ON GLOSSONEMA BOVEANUM DECNE (APOCYNACEAE)
ABSTRACT
Glossonema boveanum Decne is a hairy canescent perennial herb belonging to the Apocynaceae. Traditionally, the powdered whole plant is use for the treatment of many illnesses including epilepsy. This study is aimed at establishing some of the pharmacognostic features of the pow...
7. PHYTOCHEMICAL AND ANTI-INFLAMMATORY STUDIES OF N-BUTANOL SOLUBLE FRACTION OF THE METHANOLIC EXTRACT OF THE AERIAL PARTS OF INDIGOFERA HIRSUTA LINN (LEGUMINOSAE)
Abstract
Indigofera hirsuta Linn. (Leguminosae) is a well-known plant used in African traditional medicine as an anti-inflammatory, antibacterial, antiulcer, anti-venom and anticonvulsant. The air-dried aerial parts of I. hirsuta was extracted with methanol using a soxhlet extractor and...
8. SOME NEUROPHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF THE ETHANOLIC LEAF EXTRACT OF CUSSONIA BARTERI SEEMAN (ARALIACEAE) IN LABORATORY ANIMALS
ABSTRACT
Cussonia barteri is used in traditional medicinefor the management of convulsion and epilepsy, especially in children in Ghana and Nigeria. Literature survey revealed that the safety and efficacy of such important medicinal plant have not been scientifically validated. In the p...
9. SYNTHESIS AND ANTICONVULSANT SCREENING OF THREE ISOMERIC 3-(DIMETHYLPHENYL)AMINOPROPANAMIDES
ABSTRACT
Tremendous effort was made in this work to synthesize the three isomeric 3- (dimethylphenyl)aminopropanamides through the Michael nucleophilic substitution reaction. However, some of the results obtained after spectroscopic analysis did not satisfactorily conform to the structu...
10. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES
Abstract
The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic tech...
11. PHYTOCHEMICAL AND ANTICONVULSANT STUDIES OF METHANOL LEAF EXTRACT OF HYMENOCARDIA ACIDA, TUL (EUPHORBIACEAE)
ABSTRACT
The research was on the phytochemical and anticonvulsant studies of methanol leafextract of Hymenocardia acida, Tul, (Euphorbiaceae) used inNorthern Nigeria for the treatment of headache, rheumatic pain, sickle cell crisis, malaria, epilepsy and cancer. The preliminary phytoche...
12. PHYTOCHEMICAL SCREENING AND ANTICONVULSANT STUDIES OF ETHYL ACETATE FRACTION OF ETHANOLIC EXTRACT OF THE LEAVES OF GLOBIMETULA BRAUNII (LORANTHACEAE) PARASITING ON PILIOSTIGMA THONINGII (FABACEAE)
ABSTRACT
The ethyl acetate soluble fraction of ethanol extract of leaves of Globimetula braunii, a plant used in ethnomedicine for the treatment of epilepsy and diabetes among other ailments, was subjected to phytochemical and anticonvulsant screening. The phytochemical techniques emplo...
13. SOME NEUROPHARMACOLOGICAL STUDIES ON ETHANOL EXTRACT AND FRACTIONS OF TAPINANTHUS GLOBIFERUS A. RICH MISTLETOE ON VITELLARIA PARADOXA HOST IN LABORATORY ANIMALS
ABSTRACT
Tapinanthus globiferus is a semi-parasite mistletoe which grows on branches of large number of trees including Vitellaria paradoxa. It used locally in the management of insomnia, epilepsy, anxiety, headaches and hypertension. This study evaluated the toxicity and neuropharmacol...
14. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3 ISOMERS OF 4-[(DIMETHYLPHENYL)AMINO]-4-OXOBUTENOIC ACID
ABSTRACT
Epilepsy is a disorder of public concern worldwide and has been widely treated via pharmacotherapy, which are faced with challenges such as cost of therapy, side effects, toxicity and lack of selectivity. As such, researchers agree on the need to identify more selective, readil...
15. SOME NEUROPHARMACOLOGICAL STUDIES OF EXTRACT AND FRACTIONS OF CRINUM ZEYLANICUM(L.) (AMARYLLIDACEAE)BULB IN LABORATORY ANIMALS
ABSTRACT
Crinum zeylanicum is a medicinal plant used in folk medicine for management of general debility, infantile seizures and pain. Some neuropharmacological effects of methanolic bulb extract of Crinum zeylanicum were studied in laboratory animals.The Phytochemical screening of the...
16. PHARMACOLOGICAL RATIONALE FOR THE USE OF SOME MEDICINAL PLANTS AS ANTIEPILEPTIC AGENTS IN NIGERIA
ABSTRACT
The effects of the hydro-alcoholic root bark extracts of C. edulis and B. aegyptiaca were studied on pentylenetetrazole (PTZ) and Maximal electroshock (MES)-induced seizures in animal models. The effects of Flumazenil and Naloxone were studied on the anticonvulsant activity of...
17. PHYTOCHEMICAL AND ANTICONVULSANT STUDIES ON METHANOL EXTRACT OF THE ROOTBARK OFUVARIA CHAMAEP. BEAUV. (ANNONACEAE)
ABSTRACT
Uvariachamae P. Beauv. (Annonaceae) is widely distributed inAfrica, the plant species are used in traditional medicine as an anti-inflamatory, antimalarial, and analgesic. It is also used for treatment of jaundice, epilepsy and microbial infections. The powdered rootbark of U.c...
18. SOME NEUROPHARMACOLOGICAL PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS INGENS (MIQUEL) MIQUEL IN MICE AND CHICKS
ABSTRACT
Ficus ingens (Miquel) Miquel belongs to the Moraceae family. In some African countries, extracts of the bark are administered to cows with a low milk production, and to people suffering from anaemia, piles and diarrhea. The behavior of living organisms is a visible manifestatio...
19. ANALGESIC, ANTI-INFLAMMATORY AND ANTI-CONVULSANT ACTIVITIES OF STEM BARKEXTRACT OF Erythrophleumivorense(A Chev) IN RATS AND MICE
ABSTRACT
Erythrophleumivorense isused in traditional medicine for the treatment of convulsion, swellings, body pain and as emetic agents. There is a dearth of scientific information in support of the traditional claims. This study was therefore designed to investigate the analgesic, ant...
