EFFECT OF CHRONOMODULATED ARTESUNATE ON RENAL AND HAEMATOLOGICAL TOXICITY IN CISPLATIN-TREATED WISTAR RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Cisplatin is a non-cell-cycle dependent chemotherapeutic agent used in the treatment of several common solid tumours. However, an array of serious toxicities in various organs and systems limit its therapeutic use. Artesunate, a semisynthetic derivative of artemisinin is the recommended treatment by the WHO for severe and complicated malaria in low-transmission areas and in the second and third trimesters of pregnancy. In contrast, animal experiments show considerable toxicity upon administration of artemisinins. When malaria and cancer coexist, treatment of patients could be challenging due to the burden of disease and possible drug-drug interaction. The present study investigates the effect of 7-day chronomodulated artesunate administration on renal and haematological toxicity in cisplatin-treated rats. Four groups (n=7/group) of rats received intraperitoneal (i.p.) injection of 3 mg/kg daily dosing of cisplatin at four equispaced circadian times (00:00, 06:00, 12:00 and 18:00 h), for four days to determine the time of least renal and hematological toxicity. Another, two groups of rats (n=7/group) pre-treated with cisplatin (3 mg/kg i.p.) at 06:00 h received artesunate (60 mg/kg i.p.) at 12:00 h and 18:00 h. Parameters of the kidney function, histology of the kidneys and haematological variables were measured on day-8. Post-treatment results showed that administration of cisplatin at 06:00 h and 18:00 h appeared to produce least renal and haematological toxicity. However, kidney function as determined by urea and creatinine levels were not significantly (p>0.05) different between cisplatin-artesunate treated groups and saline control rats.. The group pre-treated with cisplatin and then artesunate at 12:00 h had higher (p<0.05) mean magnesium levels when compared to the saline control and the group pre-treated with cisplatin and then artesunate at 18:00 h. This is indicative of a less protective effect of time of artesunate administration, which is consistent with the impaired kidney histologic architecture observed. The red blood cell (RBC) and haemoglobin (HGB) vi counts were unaffected in cisplatin-artesunate treatment groups irrespective of the time of artesunate administration. However, cisplatin-treated rats that received artesunate at 12:00 h had slightly higher RBC and HGB values indicative of enhanced erythropoiesis. A reduction (p<0.05) in mean serum levels of white blood cell (WBC), platelets (PLT) and lymphocytes (LYM) was observed in both groups of rats pretreated with cisplatin and then artesunate at 12:00 h or 18:00 h. Conversely, neutrophils and monocytes (granulocytes) in these groups had higher (p<0.05) mean values indicative of time dependent immune reconstitution. The ameliorative effect of late activity span cisplatin-treatment on renal and haematological toxicity in wistar rats does not appear to be negated by 7-day chronomodulated daily administration of artesunate. However, this study illustrated the potential therapeutic value of time dependent administration of artesunate in contributing to the ameliorative effect of late activity span cisplatin dosing.
Related Project Materials
OIL-PALM PRODUCTION IN EJIGBO COMMUNITY IN OSUN STATE, 1960-2000
-
- OBJECTIVE OF THE STUDY.
Indigenous arts in Nigeria are as old as time imm...
INVESTIGATING THE BENEFITS OF EARLY CHILDHOOD EDUCATION ON SUSTAINABLE CONSUMPTION PRACTICES
ABSTRACT: Investigating the benefits of early childhood education on...
AN ASSESSMENT ON THE RELATIONSHIP BETWEEN TEACHERS’ ATTITUDE AND STUDENTS’ ACADEMIC PERFORMANCE IN BUSINESS STUDIES
ABSTRACT
The study was a descriptive research design, which focuses on teachers and students from five...
THE PROBLEMS AND PROSPECTS OF SOCIAL MARKETING IN NIGERIA MANUFACTURING ORGANISATION
ABSTRACT
The aim of this research work is to appraise “problems and prospects of social mar...
IMPACT OF PUBLIC RELATIONS IN FIRST BANK OF NIGERIA PLC
ABSTRACT
This research project was embarked upon to evaluate the role of public relations in the bankin...
ETHNO-RELIGIOUS SENTIMENT AND VOTING BEHAVIOR IN NIGERIA
Abstract
This study was carried out on ethno-religion sentiments and voting behavior in Nigeria. The resurgence of voti...
AN ASSESSMENT OF TEACHERS MOTIVATION AND ATTITUDE TO WORK AMONG SECONDARY SCHOOL TEACHERS
ABSTRACT
Motivation represents an employee’s desire and commitment, which is manifested as job performance. That is, job in high mo...
ASSESSING THE IMPACT OF TEACHING AIDS FOR EFFECTIVE TEACHING AND LEARNING OF HOME ECONOMICS IN SENIOR SECONDARY SCHOOLS
ABSTRACT
This study was set to achieve certain objectives among which are to assess the impact of teach...
AN INVESTIGATION INTO THE APPLICABILITY OF NATURAL LAW PRINCIPLES TO THE LAW OF NEGLIGENCE IN NIGERIA
Background of study
Since the beginning of the Greek civilization, the concept of natural law has play...
A SURVEY ON THE MISMANAGEMENT AND EMBEZZLEMENT OF PUBLIC FUND AND ITS IMPACTS ON GOVERNMENT PARASTATALS (A CASE SYTUDY OF FIRS, ABUJA)
Background to the study
Financial misappropriation is gaining attention throughout the world, with many...
