BEHAVIOURAL AND ANTICONVULSANT EFFECTS OF METHANOL EXTRACT OF FICUS VALLIS CHOUDAE (MORACEAE) STEM BARK
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Ficus vallis choudae is a plant widely spread in tropical Africa including Nigeria. It is said to be of value in ethnomedicine especially in the treatment of jaundice, gastrointestinal problems, giddiness and epilepsy. The anticonvulsant activity of methanol stem bark extract of Ficus vallis was studied in mice and two-day old cockrels. This study was conducted using three models; pentylenetetrazole-induced seizure test, maximal electroshock seizure test and 4-aminopyridine-induced seizure test. Also, the sedative as well as motor coordination deficit effects were studied in mice; using diazepam-induced sleep, hole-board test, and walking beam assay models respectively. The extract afforded 25.0%, 50.0% and 33.3% protections at doses of 80mg/kg, 40mg/kg and 20mg/kg respectively against pentylenetetrazole seizure model. It also significantly increased the onset of seizures at doses of 40 mg/kg and 80 mg/kg (p5,000 mg/kg (p.o.) in mice whereas that found in chicks were 774.6 mg/kg (i.p.) and >5,000 mg/kg (p.o.). The preliminary phytochemical screening reveals the presence of saponins, alkaloids, flavonoids, tannins and glycosides. These results suggest that, F. vallis extract possess biologically active compounds that have anticonvulsant properties, and are sedative in nature.
Related Project Materials
The Impact of Leadership Style on Employee Job Satisfaction: A Study of First Bank Plc in Sokoto State
Background of the Study
Leadership style is a significant factor influencing employee job satisfaction, as it shapes the wo...
DETERMINATION OF SELF-EMPLOYMENT SKILLS NEEDED BY BUSINESS EDUCATION STUDENTS IN COLLEGES OF EDUCATION IN SOUTH-WEST, NIGERIA
Background of the Study
Education is the bed rock of a nation‟s economy. It is the suitable legacy with which a child s...
The Impact of Social Media Communication on Nigerian Morphology: A Comparative Study of Instagram and Facebook
Background of the Study
Social media communication has dramatically influenced linguistic practices, particularly morpholo...
An Investigation into the Factors Influencing Clinical Nurses' Compliance with Standard Operating Procedures in Adamawa State
Background of the Study
Standard Operating Procedures (SOPs) are essential guidelines designed to ensure the consistent...
An assessment of the role of library-based ICT hubs in reducing unemployment in Ede South Local Government Area, Osun State
Background of the study
Information and Communication Technology (ICT) hubs hosted within libraries offer training in compu...
An evaluation of e-learning adoption and its effectiveness in secondary schools in Illela LGA, Sokoto State
Background of the study
E-learning has emerged as a transformative force in the educational landscape, offering flexible an...
A Study on the Effectiveness of Nurse-Led Health Education in Managing Hypertension in Kano State
Background of the Study
Hypertension is one of the most prevalent chronic conditions globally, with significant morbidity and mortality r...
The Effectiveness of Cost Management Practices in Improving SME Profitability
Background of the Study
Small and medium-sized enterprises (SMEs) are a crucial part of the economy, providing jobs and...
THE INFLUENCE OF ALCOHOL ON HEALTH BEHAVIOR OF YOUTH IN EGOR LOCAL GOVERNMENT
Abstract
Alcohol consumption among different ethnic groups in Nigeria has a long history, especially among those groups...
The Effect of Voter Registration Campaigns on Voter Turnout in Zangon Kataf LGA, Kaduna State: A Case Study of INEC’s Voter Sensitization Programs
Background of the Study
Voter registration campaigns are essential to ensuring that eligible citizens are empowered to p...
