ABSTRACT
The herbalists in several African Countries have used Rothmannia longiflora decoctions as febrifugal and analgesic agent. The present study examined the analgesic, anti-inflammatory and toxicological profile of the methanolic extract of the plant in experimental animals. The preliminary phytochemical screening of the methanolic leaf extract of R.longiflora was carried out and revealed the presence of cardiac glycoside, steroids/terpenoids, tannins, saponins, flavonoids and carbohydrates. The acute toxic effect (median lethal dose values (LD50) of methanolic leaf extract of Rothmannia longiflora was carried out using Lork’s method in intraperitoneal and oral routes in mice and rats and were found to be above 5000mg/kg body weight. The anti-nociceptive effects of the extract was studied using acetic acid induced writhing test in mice, hot plate test in mice and formalin induced pain in rats. The anti-inflammatory effect was studied using Carrageenan induced paw oedema in rats. The extract at doses of 50-1000mg/kg significantly (P0.05) of the levels of Sodium (Na+ ), Potassium (K+ ), Chloride (Cl- ) ions, Urea and Creatinine compared to that of the control at the end of 30 days (sub-chronic) and 90 days (chronic) studies. In liver function test, there was no statistically significant difference (P>0.05) in the levels of AST, ALT, and ALP enzymes in all the treated groups compared to the control group after the 30 days studies. However, there was statistically significant difference with 500mg/kg and 1000mg/kg after the 90 days treatment. The Histopathological study showed no observable gross lesions during the periods of subchronic and chronic studies. vii These findings suggest that methanolic leaf extract of R.longiflora possesses analgesic and anti-inflammatory potentials/effects that justify the ethnomedical use of the plant in the treatment of painful and inflammatory conditions by the herbal practitioners. In addition, the results of toxicity studies showed that the extract is non-toxic to the kidneys and the heart during the sub-chronic and chronic toxicity studies however; mild fatty change was observed with 500mg/kg in the liver after the chronic studies.
Abstract
Daucus carota (L.) commonly known as carrot belongs to the family of Apiaceae. The aerial part is used as component of livestock...
ABSTRACTS
This project was aimed at producing a fine high quality toilet soap at a low cost which will...
ABSTRACT
Niger State has been blessed with various tourist attraction sites and of which Gurara and Mayanka waterfalls are among. So it&r...
Abstract
This study is on the impact of microfinance bank on economic growth of Nigeria. The total population for the st...
ABSTRACT
The study examined the effect of public debt on economic growth in Nigeria, using the time fra...
Abstract
During chemistry instruction, some technical terms are required to communicate the content of the lesson. These terms are very i...
Abstract
The primary objective of this study was to assess and describes the attitude of business education student&...
EXCERPT FROM THE STUDY
BACKGROUND OF THE STUDY
Information technology has evolved into an essential component of health-care delivery.&nb...
STATEMENT OF THE PROBLEM
The key objective of SIWES is to relate theory to practice, thus before a student graduates, he...