1. THE EFFECT OF THE ETHANOLIC EXTRACT OF ANCHOMANES DIFFORMIS (BLUME) ON LIVER FUNCTIONS OF ADULT WISTAR RATS
ABSTRACT
This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRA...
2. AMELIORATIVE EFFECT OF RESVERATROL ON LEAD-INDUCED ORGAN TOXICITY IN WISTAR RATS
ABSTRACT
Resveratrol is a potent antioxidant found abundantly in grapes and in lesser quantities in peanuts, fruits and other food items. Dozens of reports have shown that resveratrol prevents or slows the progression of a wide variety of illnesses including cancer (col...
3. ANTIHYPERGLYCAEMIC AND ANTIBACTERIAL EVALUATION OF METHANOL TUBER EXTRACT OF CHLOROPHYTUM ALISMIFOLIUM BAKER (LILIACEAE)
ABSTRACT
Diabetes mellitus is a metabolic disorder which affects about 346 million people globally. Synthetic antidiabetic agents are expensive and also associated with side effects. In a bid to develop cheaper and safer antidiabetic agents, this study was carried out to determine the e...
4. CHARACTERISATION AND APPLICATION OF NATIVE AND CROSS-LINKED CASHEW (Anacardium occidentale L.) GUM IN TABLETTING
ABSTRACT
The exudate from cashew tree, referred to as cashew gum (CG) had been investigated for use as binder in conventional tablet formulations. In this study, cross-linked derivatives of the gum were synthesized and investigated for their physicochemical and physicotechnical properti...
5. APHRODISIAC AND REPRODUCTIVE STUDIES ON METHANOL ROOT BARK EXTRACT OF SECURINEGA VIROSA (ROXB. EX. WILLD.) BAILL IN MALE WISTAR RATS
ABSTRACT
Securinega virosa (SV) is a widely used plant in traditional medicine. The root is used as an aphrodisiac in north western Nigeria. The aim of the study was to provide pharmacological rationale for the ethnomedical use of the root of Securinega virosa as aphrodisiac as well as...
6. ANXIOLYTIC PROPERTIES OF MITRACARPUS VILLOSUS (SW) DC.LEAF EXTRACTS IN MICE AND RATS
ABSTRACT
The leaf of Mitracarpusvillosus (Sw.) DC. (Rubiaceae) is used in West African folk medicine for the management of a plethora of stress-related diseases including headaches and toothaches. In this study, preliminary phytochemical analysis of the ethylacetateleaf extract of Mitra...
7. EFFECT OF CHRONOMODULATED ARTESUNATE ON RENAL AND HAEMATOLOGICAL TOXICITY IN CISPLATIN-TREATED WISTAR RATS
ABSTRACT
Cisplatin is a non-cell-cycle dependent chemotherapeutic agent used in the treatment of several common solid tumours. However, an array of serious toxicities in various organs and systems limit its therapeutic use. Artesunate, a semisynthetic derivative of artemisinin is the re...
8. EVALUATION OF ANTITRYPANOSOMAL EFFECT OF STEM-BARK EXTRACTS OF SECURIDACA LONGEPEDUNCULATA (FRES. HOLL) AGAINST TRYPANOSOMA BRUCEI BRUCEI INFECTION IN WISTAR RATS
ABSTRACT
Due to numerous problems associated with current treatment of trypanosomosis, there is increasing need to find effective drug against trypanosomosis ravaging sub-Saharan Africa from traditional medicinal herbs. This work is aimed at evaluating efficacy of stem-bark extracts of...
9. EVALUATION OF PHARMACOGNOSTICPARAMETERS AND HEPATOTOXIC EFFECTS OF EXTRACTSOF CASSYTHA FILIFORMIS LINN ON PARACETAMOL-INDUCED LIVER DISORDERS IN WISTER RATS
ABSTRACT
Cassytha filiformis, a leafless and perennial vine with small scales as a replacement of the leavesis currently being used in the treatment of various disease conditions including jaundice without standardization.Microscopical evaluation, chromatographic analysis (TLC, HPLC, LC...
10. HEPATOPROTECTIVE AND WOUND HEALING PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS PLATYPHYLLA Del. Holl (MORACEA)
ABSTRACT
Ficus platyphylla (Fp) is a medicinal plant that is widely used in Northern part of Nigeria for the management of skin problems such as eczema and topical application of its gum (latex) to wounds. It is also used for treating malaria and psychosis. Its antioxidant, hepatoprotec...
11. HYPOTENSIVE ACTIVITY AND TOXICOLOGICAL PROFILE OF STEM BARK EXTRACT OF SYZYGIUM GUINEENSE (Willd, D.C. Myrtaceae) IN LABORATORY ANIMALS
ABSTRACT
Hypertension of unknown cause is called essential or primary hypertension while hypertension of a known cause is called secondary hypertension. Hypertension is called a silent killer because it is usually asymptomatic. It is a global problem affecting 1 in 3 adults in the Unite...
12. PHARMACOLOGICAL INTERACTION BETWEEN ETHANOL EXTRACT OF MORINGA OLEIFERA LEAVES AND METFORMIN IN ALLOXANINDUCED HYPERGLYCAEMIC WISTAR RATS
Abstract
Herbs with anti-diabetic activity could initiate interactions if used concurrently with orthodox drugs. Moringa oleifera is one of such herbs usually taken as an adjunct to orthodox oral hypoglycaemic agents. This study investigated the possible pharmacological interaction betw...
13. STUDIES ON ANTIHAEMORRHAGIC AND ANTIBACTERIAL PROPERTIES OF BULB JUICE, ETHANOL AND AQUEOUS EXTRACTS OF ALLIUM SATIVUM LINN. (LILLIACEAE) AGAINST MENINGEAL BACTERIA
ABSTRACT
Bacterial meningitis (BM) is a devastating air-borne infectious disease of humans that causes cellular hemorrhagic sepsis, metabolic, neurologic and endocrine disorders and constitutes a serious threat to public health. Where malnutrition is linked to BM, it is a great economic...
14. THE COMPARATIVE EFFECTS OF AQUEOUS AND ETHANOL FRUIT EXTRACTS OF PHOENIX DACTYLIFERA ON THE HIPPOCAMPUS AND CEREBELLAR CORTEX OF ARTESUNATE-AMODIAQUINE TREATED ADULT WISTAR RATS
ABSTRACT
Amidst the current rise in the usage of artemisinin-based combination therapies as the first line treatment of falciparum resistant malaria in the Tropics, artesunate-amodiaquine combination therapy have been found to have degenerative and toxicity effects. This study was aimed...
15. TOXICITY AND IMMUNOMODULATORY PROPERTIES OF METHANOL EXTRACT OF THE STEM BARK OF LANNEA ACIDA A. RICH. (ANACARDIACEAE) IN WISTAR RATS
ABSTRACT
Lannea acidaA. Rich.belongs to the family of Anacardiaceae; and the bark, leaves and roots have been reported to possess many medicinal properties, including immunomodulatory activity.Despite this widespread belief, data on the immunomodulatory properties and safety of this pla...
16. TOXICOLOGICAL AND ANTI-HYPERGLYCAEMIC PROPERTIES OF AQUEOUS LEAF EXTRACT OF PERSEA AMERICANA MILL (LAURECEAE) IN NORMOGLYCAEMIC AND ALLOXAN-INDUCED HYPERGLYCAEMIC WISTAR RATS
ABSTRACT
Diabetes mellitus has become a global health burden leading to an increase in the search for herbal anti-hyperglycaemic agents as alternative to synthetic ones. Persea americana popularly known as avocado pear have been known for its nutritional and medicinal properties. The le...
17. TOXICOLOGICAL ASSESSMENT OF THE METHANOL LEAF EXTRACT OF SECURINEGA VIROSA(ROXB EX. WILLD) IN WISTAR RATS
ABSTRACT
Securinega virosa is one of the African medicinal plants described as a true “cure all” among traditional practitioners. Different parts of Securinega virosa have been used in the management of different disorders in Nigeria and other parts of the world. There is th...
18. DIURETIC AND TOXICITY STUDIES OF METHANOL STEM BARK EXTRACT OF SPONDIAS MOMBIN LINN (ANACARDIACEAE) IN RATS
ABSTRACT
Spondias mombin belongs to the family Anacardiacae. All parts of the tree are reported to be medicinally useful. The fruit juice is drunk as a diuretic and febrifuge. The main aim of the study is to determine the diuretic activity and toxicity of methanol stem bark extract of S...
19. EFFECTS OF ANTIMALARIAL DRUGS ON OESTROUS CYCLE AND UTERINE CONTRACTILITY IN RATS
ABSTRACT
Malaria is increasingly a health burden globally with children under the age of 5 and pregnant women being the most vulnerable. Several antimalarials are available in the market today however; the safety data in pregnancy is inadequate especially the first trimester of pregnanc...
20. EFFECTS OF VITAMIN B COMPLEX THERAPY ON TEMPORAL VARIATION IN GENTAMICIN NEPHROTOXICITY IN WISTAR RATS
ABSTRACT
The efficacy and toxicity of several drugs is circadian-rhythm dependent, and this can be exploited as a guide to ameliorate such drug toxicity. Gentamicin is an aminoglycoside antibiotic used in treatment of a variety of infections. Its use is however limited by its associated...
21. EVALUATION OF THE GASTROPROTECTIVE AND SUB-CHRONIC TOXICITY OF METHANOL STEM BARK EXTRACT OF XIMENIA AMERICANA LINN (OLACACEAE) IN MALE WISTAR RATS
Abstract
Ximenia americana is a plant used traditionally in northern parts of Nigeria for treatment of leprotic ulcers and mouth ulcers in addition to other medicinal uses. It contains flavanoids, saponins, tannins among others that has been reported to possess gastroprotective potentia...
22. GASTRO-INTESTINAL MUCOSAL PROTECTIVE PROPERTIES AND TOXICITY STUDIES ON THE METHANOL ROOT EXTRACT OF WALTHERIA INDICA LINN. (STERCULIACEAE) IN LABORATORY ANIMALS
ABSTRACT
Many countries worldwide including Nigeria use different parts of Waltheria indica (leaves, stem-barks, roots and whole plants) to treat various ailments. In Nigeria, Waltheria indica is used to treat gastro-intestinal ulcers, pain, inflammation, diarrhoea, conjunctivitis, anae...
23. PHARMACOGNOSTIC, NUTRITIONAL AND TOXICITY STUDIES ON THE AERIAL PART OF DAUCUS CAROTA L. (APIACEAE)
Abstract
Daucus carota (L.) commonly known as carrot belongs to the family of Apiaceae. The aerial part is used as component of livestock feed in some part of Northern Nigeriawithout any scientific evidence ofsafety. The present study was carried out to establish its pharmacognostic, nu...
24. SOME PHARMACOLOGICAL PROPERTIES OF METHANOL EXTRACT OF ANISOPUS MANNII N.E.Br (ASCLEPIADACEAE) IN ALLOXAN-INDUCED HYPERGLYCAEMIC WISTAR RATS
ABSTRACT
Diabetes mellitus is a metabolic disorder that affects carbohydrates, lipids and proteins resulting in sustained hyperglycaemia which could lead to serious organ(s) damage and death. The aim of this study was to investigate some of the pharmacological properties of the methanol...
25. EFFECT OF AQUEOUS ETHANOL LEAF EXTRACT OF COMBRETUM MICRANTHUM G. DON (COMBRETACEAE) ON SOME INDUCED SYSTEMIC INFLAMMATORY IMMUNE RESPONSE SYNDROMES IN MICE AND RATS
Abstract
The cellular immunity is often suppressed by infection, disease conditions and drug medication that are in continous association with mankind. Combretum micranthum is a plant known for its antioxidant, antimicrobial, anti-inflammatory and various other properties of immune boos...
26. SOME NEUROPHARMACOLOGICAL STUDIES OF EXTRACT AND FRACTIONS OF CRINUM ZEYLANICUM(L.) (AMARYLLIDACEAE)BULB IN LABORATORY ANIMALS
ABSTRACT
Crinum zeylanicum is a medicinal plant used in folk medicine for management of general debility, infantile seizures and pain. Some neuropharmacological effects of methanolic bulb extract of Crinum zeylanicum were studied in laboratory animals.The Phytochemical screening of the...
27. STUDIES ON IN-VIVO ANTIOXIDANT AND HEPATOPROTECTIVE PROPERTIES OF CITRUS SINENSIS (L.) OSBECK PEEL EXTRACT IN WISTAR RATS
ABSTRACT
Citrus sinensis is the commonest, most widely cultivated and consumed citrus fruit. Large amounts of peel wastes are formed when citrus is consumed or processed; and suitable methods have to be adopted to utilize these waste materials for conversion into value-added products. F...
28. EVALUATION OF AQUEOUS AND METHANOL ROOT EXTRACTS OF CALOTROPIS PROCERA AIT (ASCLEPIADACEAE) FOR ANTI-ASTHMATIC ACTIVITY ON WISTAR RATS AND GUINEA PIG ILEUM
ABSTRACT
Asthma, which affects an estimated 300 million people worldwide, is an incurable health disorder of a major public health concern globally. The present orthodox therapy for asthma has several drawbacks including many undesirable side effects and high cost of management (especia...
29. PHARMACOGNOSTIC AND PRO-FERTILITY EVALUATIONS OF DRACAENA ARBOREA (WILLD) LINN. (DRACAENACEAE)
ABSTRACT
The plant Dracaena arborea (Willd) Linn is a member of the Dracaenaceae family. It grows abundantly in western Nigeria where its leaves are used as traditional herbal treatment for male infertility and as aphrodisiacs and also in the treatment of gonorrhoea, viral ailments like...
30. ANTILIPIDEMIC EFFECT OF WATER (H20) EXTRACT OF DESMODIUM VELUTINUM LEAVES ON ALBINO WISTAR RATS
ABSTRACT
This study evaluated the antilipidemic activity of water extracts from leaves of Desmodium velutinum on albino wistar rats. The phytochemical analysis of the leaf extract showed the presence of tannins, saponins, alkaloids, soluble carbohydrates, flavonoids, reducing sugar, ste...
31. PHYTOCHEMICAL AND ANTI-INFLAMMATORY PROPERTIES OF METHANOL EXTRACT OF CRATEVA ADANSONII STEM BARK.
ABSTRACT
78 This research investigated the phytochemical and anti-inflammatory properties of methanol extract of Crateva adansonii stem bark. Although several edible and non-edible plants parts are used in inflammatory treatment, many record has been found of the use of Crateva ad...
32. THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN
ABSTRACT
Kola bark extract have been widely used in tradition medicine for thousand of year, it improves liver functions and provides protection against high fat fed metabolic rats. Present investigations were carried out on the hepatoprotective role of Kola bark extract meal treatment...
33. THE EFFECT OF ETHANOL EXTRACT OF DESMODIUM VELUTINUM STEM ON SOME MARKER EMZYME IN LIVER OF ALBINO WISTAR RATS
Abstract
Present investigations were carried out on the effect of ethanol extract of Desmodium velutinum stem on some liver enzymes of albino wistar rats fed with 8 high fat from cow‟s brain. Twelve healthy albino wistar rats were divided into four groups. Group I rats were fed with bal...
34. THE EFFECT OF PTEROCARPUS MILDBREADII SEED ON PLASMA HDL CHOLESTEROL OF ALBINO RAT
ABSRACT
This work was carried out to investigate the effects of pterocarpus mildbreadii seed on the HDL- level of albino rats.High density lipoprotein(HDL) is a fraction of cholesterol,which helps to transport cholesterol from peripheral of cell to the liver.High density lipoprotein is...
35. THE EFFECT OF WATER EXTRACT OF COLA NITIDA POD ON LIPOPROTEIN CONCENTRATIONS OF ALBINO WISTAR RATS
ABSTRACT
Cola nitida has been in use in the eastern parts of Nigeria for the management of certain ailments and as an aphrodisiac in the management of some sexual dysfunctions. However the effects of this extract in some health parameters in human objects have not been reported. This wo...
36. NUTRITIONAL, SENSORY AND STORAGE PROPERTIES OF SNACK PRODUCED FROM MAIZE (Zea mays Linn) AND AFRICAN YAM BEAN SEED (Sphenostylis stenocarpa Hochst Ex A. Rich) FLOUR BLENDS
ABSTRACT
Low nutritional value and inconsistent sensory qualities arising from crude and nonstandardised processing operations characterise most Nigerian maize-based snacks including kokoro. African Yam Bean Seed (AYB) is an underutilised crop with high nutritional value, but literature...
37. ANALGESIC, ANTI-INFLAMMATORY AND ANTI-CONVULSANT ACTIVITIES OF STEM BARKEXTRACT OF Erythrophleumivorense(A Chev) IN RATS AND MICE
ABSTRACT
Erythrophleumivorense isused in traditional medicine for the treatment of convulsion, swellings, body pain and as emetic agents. There is a dearth of scientific information in support of the traditional claims. This study was therefore designed to investigate the analgesic, ant...
38. ANTIDIABETIC PROPERTIES OF MUCUNA PRURIENS L. (D.C.) SEED EXTRACT AND ITS TABLET FORMULATIONS
ABSTRACT
Diabetes mellitus and its complications continue to be one of the highest causes of morbidity and mortality in recent times. Although many drugs are commercially available for use in the management of diabetes, their side effects and high costs underscore the need for new drugs...
39. EFFECT OF Phyllanthus amarus AND N-HEXADECANOIC ACID ON BLOOD COAGULATION PARAMETERS OF LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION IN WISTAR RATS
ABSTRACT
Blood clotting is a complex sequence of processes involving multiple proteins (factors) that must operate in a specific order to create a clot. The procedure is rapid and effective, but it must be monitored because uncontrolled clotting can lead to thrombosis. A shift in the ba...
40. CHRONIC TOXICITY EXTRACTION OF AFRICAN MESQUITE TREE PART EXTRACT IN RAT
ABSTRACT
This study investigated the chronic toxicity of African Mesquite tree (Prosopis africana) extracts in Wistar rats, focusing on biochemical, hematological, and histopathological effects. The extracts were administered at doses of 100 mg/kg, 300...
