1. HEPATITIS B (HBV) SEROLOGICAL MARKERS RELATIONSHIP WITH VITB12 DEFICIENCY
Background of the study
Hepatitis B virus (HBV) is one of the most common chronic infections worldwide and the leading cause for hepatocellular carcinoma (HCC) worldwide.Based on WHO (2012) report, one‐third of the world population estimated a...
2. ASSESSMENT ON THE ROLE OF PLANTS IN THE TREATMENT OF DISEASES CAUSED BY MICRO-ORGANISMS BASED IN THE NATURAL PRODUCTS
BACKGROUNG OF STUDY
Infectious diseases are a significant cause of morbidity and mortality worldwide, accounting for approximately 50% of all deaths in tropical countries and as much as 20% of deaths in the Americas. Despite the significant progress made in microb...
3. STUDIES ON THE EFFECT OF GARLIC AND HONEY ON SOME UPPER RESPIRATORY TRACT INFECTIONS
Background Of The Study
Upper Respiratory Tract Infections, often known as URIs or URTIs, are a group of diseases that are brought on by an acute infection of the upper respiratory tract, which includes the nose, sinuses, pharynx, and larynx. Tonsilliti...
4. THE IMPORTANCE OF BLOOD CULTURES IN THE DIAGNOSTIC AND THERAPEUTIC PROCESS OF SEPTICEMIA
ABSTRACT
A study of septicaemia was conducted in Enugu metropolis with a view to determine the relevance of blood culture to the diagnosis and treatment of this disease. The subjects comprised of Six hundred and fifty (650) children and adults of both sexes aged between one day to...
5. POSSIBLE EFFECTS OF ELECTROMAGNETIC FIELDS (EMF) ON HUMAN HEALTH
ABSTRACT
This work on ”Possible effects of Electromagnetic Fields (EMF), Radio Frequency Fields (RF) and Microwave Radiation on human health”, with respect to whether or not exposure to electromagnetic fields (EMF) is a cause of disease or other health effec...
6. RELEVANCE OF BLOOD CULTURE TO THE DIAGNOSIS AND TREATMENT OF SEPTICEMIA
ABSTRACT
A study of septicaemia was conducted in Enugu metropolis with a view to determine the relevance of blood culture to the diagnosis and treatment of this disease. The subjects comprised of Six hundred and fifty (650) children and adults of both sexes aged between one day to 70 ye...
7. PHYTOCHEMICAL ANALYSIS OF SELECTED TOMATO PRODUCTS
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INTRODUCTION
INTRODUCTION
Intake of tomato and tomato based-products contributes to the absorption of a wide range of carotenoids in human serum and tissues. The prominent carotenoid in tomatoes is lycopene, a pigment principally responsible for the deep...
8. INVITRO DETERMINATION OF BACTERIOCIDAL EFFECT OF GARLIC ON STAPHYLOCOCCUS AUREUS
ABSTRACT
Invitro determination of bacteriocidal effect of garlic extract on staphylococcus aureus causing skin and urinary tract infection (UTI) on some female patients were studied.
High...
9. POSSIBLE EFFECTS OF ELECTROMAGNETIC FIELDS (EMF) ON HUMAN HEALTH
ABSTRACT
This work on ”Possible effects of Electromagnetic Fields (EMF), Radio Frequency Fields (RF) and Microwave Radiation on human health”, with respect to whether or not exposure to electromagnetic fields (EMF) is a cause of disease or other health effec...
10. ANTIDIARRHOAEL EFFECT OF METHANOL STEM BARK EXTRACT OF HYMENOCARDIA ACIDA (EUPHOBIACEAE) IN LABORATORY ANIMALS
Abstract
The objective of the present study was to evaluate the antidiarrheal activity of the methanol stem bark extract of Hymenocardia acida in some laboratory animals. They methanol stem bark extract of Hymenocardia acida (MEHA) was prepared from the freshly collected stem bark of th...
11. CHEMICAL AND BIOLOGICAL STUDIES OF HONEY BEE PROPOLIS COLLECTED FROM ZANGO KATAF LOCAL GOVERNMENT AREA OF KADUNA STATE, NIGERIA
ABSTRACT
Honeybee Propolis from Apis mellifera (Linn), has been used in ethno medicine as an emollient in the treatment of ringworm, measles, chickenpox and with reported biological activities, such as antitumor, antioxidant, immunomodulatory action and anti-inflammatory action among ot...
12. CONTROLLED RELEASE FORMULATIONS OF ANTIRETROVIRAL (ARV) DRUGS USING POLYMETHACRYLATE POLYMERS
ABSTRACT
To improve patient compliance and ensure better success in the management of HIV, spansule technology was employed to formulate controlled release dosage drug. Generic forms of seven of the most commonly used Anti-retro viral (ARV) drugs (didanosine, indinavir, lamivudine, nelf...
13. ANTIFUNGAL ACTIVITIES OF ETHYL ACETATE FRACTION OF PSEUDOMONAS FLUORESCENS FERMENTATION BROTH AGAINST PHYTOPATHOGENIC FUNGI FROM ROTTEN YAM
ABSTRACT
Yam tubers are prone to infestation by microorganism at all stages of growth and in storage. This rot reduces the quality of yam and affects food security. Pseudomonas fluorescens possess varieties of promising antifungal properties through production of secondary metabolites w...
14. ANTIHYPERGLYCAEMIC AND ANTIBACTERIAL EVALUATION OF METHANOL TUBER EXTRACT OF CHLOROPHYTUM ALISMIFOLIUM BAKER (LILIACEAE)
ABSTRACT
Diabetes mellitus is a metabolic disorder which affects about 346 million people globally. Synthetic antidiabetic agents are expensive and also associated with side effects. In a bid to develop cheaper and safer antidiabetic agents, this study was carried out to determine the e...
15. ANTIMALARIAL SUSCEPTIBILITY AND DRUG RESISTANCE CHARACTERIZATION STUDIES OF PLASMODIUM SPECIES ISOLATES FROM PATIENTS IN NIGERIA
ABSTRACT
About half of Nigerian population experience at least one episode of malaria per year, resulting in high morbidity and mortality and loss of economic value. Retrospective study of the profile of malarial patients and the antimalarial drugs prescribed at Umaru Musa Yaradua memor...
16. CHARACTERISATION AND APPLICATION OF NATIVE AND CROSS-LINKED CASHEW (Anacardium occidentale L.) GUM IN TABLETTING
ABSTRACT
The exudate from cashew tree, referred to as cashew gum (CG) had been investigated for use as binder in conventional tablet formulations. In this study, cross-linked derivatives of the gum were synthesized and investigated for their physicochemical and physicotechnical properti...
17. COMPARATIVE BIOEQUIVALENCE STUDIES OF SOME SELECTED BRANDS OF CIPROFLOXACIN TABLETS MARKETED IN NIGERIA
ABSTRACT
Comparative bioequivalence studies of six selected brands of ciprofloxacin tablets was successfully conducted. In-vitro quality control studies were carried out on six randomly selected brands of ciprofloxacin to establish identity, weight uniformity, friability, crushing stren...
18. COMPARATIVE IN-VITRO BIOEQUIVALENCE STUDIES OF DIFFERENT SAMPLES OF TINIDAZOLE TABLETS
ABSTRACT
Health care professionals are faced with a large number of multisource products from which therapeutically equivalent products are being selected for various reasons. Consequently, an increased availability and use of generic products has been seen during the last four decades....
19. COMPARATIVE BIOEQUIVALENCE STUDIES OF SOME BRANDS OF METRONIDAZOLE TABLETS MARKETED IN ZARIA, NIGERIA
ABSTRACT
Multisource pharmaceutical products are intended to be pharmaceutically equivalent or pharmaceutical alternatives that are bioequivalent and hence are therapeutically equivalent and interchangeable. Thus, this study was aimed at carrying out a comparative in-vitro and in-vivo b...
20. COMPARATIVE EVALUATION OF THE HYPOTENSIVE EFFECTS OF THE SEED AND LEAF EXTRACTS OF MORINGA OLEIFERA LAM (Moringaceae) IN LABORATORY ANIMALS
ABSTRACT
Moringa oleifera is locally used in Nigeria for the management of respiratory disorders, hypertension and poor blood circulation among other ailments. However, all parts of the plant are blindly used because the exact part of this plant and / or extractive solvent that provides...
21. COMPARATIVE IN VITRO BIOEQUIVALENCE EVALUATION OF SIX BRANDS OF AMOXICILLIN CAPSULE MARKETED IN DUTSE, JIGAWA STATE, NIGERIA
ABSTRACT
Comparative in vitro bioequivalence study of biopharmaceutics class I and III drugs hadgained prominence in recent times. In vitro bioequivalence offered many benefits compared to conventional in-vivobioequivalence studies, due to its reduced cost and time of product release as...
22. COMPARATIVE IN-VITRO BIOEQUIVALENCE STUDIES OF SOME BRANDS OF METRONIDAZOLE TABLET MARKETED IN ZARIA, KADUNA STATE
ABSTRACT
Metronidazole is an antibacterial and antiprotozoal drug used in the treatment of amebiasis, giardiasis, trichomoniasis and other microbial diseases. It is an essential drug commonly found in Nigerian market and has so many generics and dosage forms under various trade names by...
23. EVALUATION OF ANTITRYPANOSOMAL EFFECT OF STEM-BARK EXTRACTS OF SECURIDACA LONGEPEDUNCULATA (FRES. HOLL) AGAINST TRYPANOSOMA BRUCEI BRUCEI INFECTION IN WISTAR RATS
ABSTRACT
Due to numerous problems associated with current treatment of trypanosomosis, there is increasing need to find effective drug against trypanosomosis ravaging sub-Saharan Africa from traditional medicinal herbs. This work is aimed at evaluating efficacy of stem-bark extracts of...
24. FORMULATION STUDIES OF TABLETS CONTAINING ADANSONIA DIGITATA L. MUCILAGE AS MATRIX FORMER
ABSTRACT
The aim of this study was to investigate the ability of Adansonia digitata mucilage (ADM), a hydrophilic plant polymeric material to prolong the release of Metoprolol tartarate (MPT) from matrix tablet formulations compared with semi -synthetic polymer-HPMC60SH4000 matrices. Ph...
25. HEPATOPROTECTIVE AND WOUND HEALING PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS PLATYPHYLLA Del. Holl (MORACEA)
ABSTRACT
Ficus platyphylla (Fp) is a medicinal plant that is widely used in Northern part of Nigeria for the management of skin problems such as eczema and topical application of its gum (latex) to wounds. It is also used for treating malaria and psychosis. Its antioxidant, hepatoprotec...
26. HYPOTENSIVE ACTIVITY AND TOXICOLOGICAL PROFILE OF STEM BARK EXTRACT OF SYZYGIUM GUINEENSE (Willd, D.C. Myrtaceae) IN LABORATORY ANIMALS
ABSTRACT
Hypertension of unknown cause is called essential or primary hypertension while hypertension of a known cause is called secondary hypertension. Hypertension is called a silent killer because it is usually asymptomatic. It is a global problem affecting 1 in 3 adults in the Unite...
27. PHARMACOGNOSTIC AND ANTIVENIN STUDIES ON LEAVES OF SECURINEGA VIROSA (ROXB EX WILLD) BAILL
ABSTRACT
7 Securinega virosa (Roxb ex Willd) Baill (Euphorbiaceae) is a small, deciduous, graceful shrub that is widely distributed in Africa. It is used to treat snakebites, syphilis, rheumatism and malaria. Plant based medicines are limited in use because of inadequate standardization...
28. AN IN VITRO STUDY OF THE ANTIBACTERIAL PROPERTIES OF SELECTED PLANT SPECIES FOUND IN ADAMAWA STATE, NIGERIA
ABSTRACT
The antibacterial activity of plant extracts compared to a known antibiotic (ampicillin) was evaluated against ten gram-negative and gram-positive bacteria which can infect humans. In addition, the efficacies of different extraction methods were studied. Soxhlet, cold aqueous,...
29. SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM
ABSTRACT
The aim of this study was to enhance the solubility and hence dissolution rate of two poorly soluble drugs: ibuprofen and piroxicam using Eudragit RS 100 and hydroxymethylpropylcellulose (HPMC) as carriers, by solid dispersion technique and to evaluate the effect of trona (sodi...
30. STUDIES ON ANTIHAEMORRHAGIC AND ANTIBACTERIAL PROPERTIES OF BULB JUICE, ETHANOL AND AQUEOUS EXTRACTS OF ALLIUM SATIVUM LINN. (LILLIACEAE) AGAINST MENINGEAL BACTERIA
ABSTRACT
Bacterial meningitis (BM) is a devastating air-borne infectious disease of humans that causes cellular hemorrhagic sepsis, metabolic, neurologic and endocrine disorders and constitutes a serious threat to public health. Where malnutrition is linked to BM, it is a great economic...
31. EFFECT OF CAFFEINE ON PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS: A CASE STUDY OF PANADOL EXTRA®
ABSTRACT
Acetaminophen or paracetamol is an analgesic and anti-pyretic agent widely used for treatment of headaches, minor pains and in combination with other medications like cold remedies and opoid analgesics. Individuals with headaches and minor pains tend to use paracetamol with caf...
32. PHYTOCHEMICAL AND SOME BIOLOGICAL STUDIES OF THE METHANOL LEAF EXTRACT OF ASPILIA AFRICANA (PERS.) C. D. ADAMS (ASTERACEAE)
Abstract
Aspilia africana, (Pers) C.D. Adams; (Asteraceae), a semi perennial woody plant, commonly known as haemorrhage plant is widely distributed across tropical Africa and all parts of Nigeria. The plant is well known in folkloric medicine for its anti-haemorrhagic uses and for the t...
33. PHYTOCHEMICAL AND ANTIVENOM EVALUATIONS OF METHANOL LEAF EXTRACT OF CLERODENDRUM CAPITATUM (WILLD) SCHUM. AND THONN. (VERBENACEAE)
ABSTRACT
Clerodendrum capitatum (Willd) Schumach and Thonn. is a common medicinal plant found mainly in the tropical and sub-tropical regions of the world where it is used in traditional medicine for the treatment of various conditions including erectile dysfunction, wounds, diabetes me...
34. PHYTOCHEMICAL, ANTIOXIDANT AND ANTISNAKE VENOM STUDIES OF THE METHANOL EXTRACT OF THE ROOT BARK OF PHYLLANTHUS MUELLERIANUS (KUNTZE) EXCELL
ABSTRACT
Phyllanthus muellerianus is distributed in secondary forests from Guinea-Bissau, Mali, West Cameroons and other parts of tropical Africa. It is a shrub or climber deciduous and occasionally arborescent. The root bark of this plant was extracted by maceration using methanol. The...
35. SOME UTEROTONIC PROPERTIES OF AQUEOUS LEAF EXTRACT OF SIDA CORYMBOSA (Fries) IN LABORATORY ANIMALS
ABSTRACT
Uterotonic property is the characteristic innate ability of a substance to spontaneously initiate and maintain uterine contractions due to its chemical composition. Over centuries, sub-saharan Africans have been using Sida corymbosa leaf extract during labour with the claims th...
36. THE USE OF GELATIN-ACACIA CO-PRECIPITATE (GELAC) IN THE FORMULATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM
ABSTRACT
Gums find application in tablet formulation as binder because of their adhesive nature. Natural gums are promising biodegradable polymeric materials. The aim of this study was to prepare a gelatin and acacia co-precipitate (GelAc) to be used as a release retardant in the formul...
37. DEVELOPMENT OF A FILLER-BINDER DISINTEGRANT FOR DIRECT COMPRESSION TABLETING BY CO-PROCESSING MICROCRYSTALLINE CELLULOSE AND CROSPOVIDONE
ABSTRACT
The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to o...
38. EFFECTS OF ENVIRONMENTAL EXPOSURE ON THE PHARMACOKINETICS OF CIPROFLOXACIN TABLET IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
Ciprofloxacin is a flouroquinololone antibiotic that is commonly prescribed empirically in Nigeria due to its broad spectrum of activity. However, the drug product is illegally handled by drug hawkers that allow the drug to be exposed to some environmental forces which may affe...
39. EVALUATION OF THE DISSOLUTION AND OTHER CHARACTERISTICS OF CYCLODEXTRIN MOLECULAR INCLUSION COMPLEXES OF ARTEMETHER
ABSTRACT
The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-β-cyclodextrin. The solid complexes of artemether and hydroxypropy...
40. ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST PHYTOPATHOGENIC YAM ROT FUNGI SPORES IN NIGERIA
ABSTRACT
Postharvest deterioration has been a major problem associated with yam storage for both farmers and traders and it is caused mostly by micro-organisms especially fungi. The antifungal activity of some commonly used anti-dermatophytic agents (Fluconazole, Terbinafine Hcl, Ketoco...
41. IN VITROANTIMALARIAL SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM ISOLATES FROM PATIENTS ATTENDING A HEALTH FACILITY IN NIGERIA
ABSTRACT
The continous emergence and spread of resistant strains of Plasmodium falciparumisolates to single and combined antimalarial drug has resulted to increase in mortality rate associated with the disease, especially in the African Continent as a whole and Nigeria in particular whe...
42. PHARMACOGNOSTIC AND ANTIOXIDANT STUDIES OF THE PSEUDOBULBS OF EULOPHIA GUINEENSIS LINDL (ORCHIDACEAE)
ABSTRACT
Eulophia species are cultivated worldwide; it is one of the largest orchid‘s genera in Africa. They are believed to cure many diseases. Eulophia guineensis Lindl (Orchidaceae) is a multipurpose plant, native to West Africa. Traditionally, it is exploited in the treatment...
43. PHYTOCHEMICAL STUDIES AND EFFECT OF METHANOL LEAF EXTRACT OF LEPTADENIA HASTATA(PERS.) DECNE (ASCLEPIADACEAE) ON ACETIC ACID INDUCED WRITHES IN MICE AND VENOM OF ECHIS OCELLATUS
ABSTRACT
Leptadeniahastata (Pers.) Decne (Asclepiadaceae) is widely African plant species used in traditional medicine as an anti-venom, antihypertensive, anti-diabetic, analgesic and also used for catarrh and skin disease. The powdered leaves of L. hastatawas extracted with methanol us...
44. SUSCEPTIBILITY PROFILES OF SOME BACTERIA ISOLATED FROM STOOL OF DIARRHOEAL PATIENTS TO THE STEM AND ROOT BARKS EXTRACTS OF FICUS SYCOMORUS Linn (Moracae)
ABSTRACT
Effective antibiotic management of diarrhoea caused by bacterial organisms faces challenge of antibiotic resistance which combines to pose serious problems. Local people often use some plants to treat diarrhoea. The efficacy of one of such plant is the subject of this investiga...
45. EVALUATION OF AQUEOUS AND METHANOL ROOT EXTRACTS OF CALOTROPIS PROCERA AIT (ASCLEPIADACEAE) FOR ANTI-ASTHMATIC ACTIVITY ON WISTAR RATS AND GUINEA PIG ILEUM
ABSTRACT
Asthma, which affects an estimated 300 million people worldwide, is an incurable health disorder of a major public health concern globally. The present orthodox therapy for asthma has several drawbacks including many undesirable side effects and high cost of management (especia...
46. A CRITICAL ANALYSIS OF ARTIFICIAL HUMAN REPRODUCTION: AN ISLAMIC LAW PERSPECTIVE
ABSTRACT
Reproductive rights attained recognition at the 1994 Cairo International Conference on Population and Development (ICPD) with the proclamation that reproductive rights embraces “the right to attain the highest standard of sexual and reproductive health and the right to ma...
47. ANTIBACTERIAL ACTIVITY OF HELIANTHUS ANNUUS SEEDS EXTRACT ON SALMONELLA SPECIES AND ESCHERICHIA COLI
ABSTRACT Medicinal plants contain active ingredients with therapeutic values. Helianthus annuus L (Asteraceae) commonly referred to as “sunflower” has been reportedly used in managing and treating some ailments over the years. This study investigated the in vitro and in vivo antibacte...
48. ANTI-PLASMODIAL EFFECTS OF POLYALTHIA LONGIFOLIA (VAR.) LEAF EXTRACTS AGAINST PLASMODIUM BERGHEI IN MICE
ABSTRACT Malaria is one of the most debilitating tropical parasitic diseases and the greatest cause of hospitalization and death. Recurring problems of drug resistance are reinforcing the need for finding new antimalarial drugs. In this respect, natural plant products are the main sources of biol...
49. STUDIES OF LISTERIA MONOCYTOGENES (BACTERIUM) IN SOME SELECTED LOCAL GOVERNMENT AREAS OF PLATEAU STATE, NIGERIA
ABSTRACT
Studies were carried out on the distribution, characterization, pathogenicity and antibiotic susceptibility of Listeria monocytogenes in Six Local Government Areas of Plateau State, Nigeria. A total of One hundred and fifty (150) experimental samples were taken from each test L...
50. EVALUATION OF ANTIFUNGAL EFFICACY OF SOME LEAF EXTRACTS OF SOME PLANTS ON RED ROT PATHOGEN (Colletotrichum falcatum) OF SUGARCANE (Saccharum officinarum)
ABSTRACT
Botanical extracts have shown appreciable achievement in controlling plant diseases. This became evident in this study when the potency of leaf extracts from Azadirachta indica, Carica papaya, Lawsonia inermis, Khaya senegalensis and Ziziphus spina- christi were tested on the m...
