1. ANTICONVULSANT AND SUB-CHRONIC TOXICITY STUDIES OF THE METHANOL LEAF EXTRACT OF DIOSPYROS MESPILIFORMIS HOCHST (EBENACEAE) IN LABORATORY ANIMALS
ABSTRACT
Diospyros mespiliformis hochst (Ebenaceae) known in English as ebony is a plant that is found throughout West Africa. The Plant was reported to have wide ethnomedical application notably in fever, whooping cough, wounds, pneumonia, syphilis, leprosy and epilepsy among others. T...
2. ANTICONVULSANT STUDIES ON METHANOL LEAF EXTRACT OF LAGGERAAURITA LINN.F.IN LABORATORY ANIMALS
ABSTRACT
LaggeraauritaLinn. belongs to the family of Asteraceae. It is an annual herb which is found growing as weeds in Nigeria and spread throughout the sub-Saharan Africa. In Nigeria, Laggeraaurita is used asa remedy for pediatric malaria and in the management of epilepsy in Niger st...
3. EFFECTS OF ADMINISTRATION OF CARBAMAZEPINE, PHENYTOIN AND THEIR COMBINATION ON NEUROBEHAVIOURAL, COGNITIVE HAEMATOLOGICAL AND SERUM BIOCHEMICAL CHANGES IN ALBINO RATS
ABSTRACT
The aim of the study was to evaluate the neurobehavioural patterns, cognitive functions and haemato-biochemical changes following the administration of carbamazepine (CBZ), phenytoin (PHE) and their combination. Forty, apparently healthy adult male Albino rats weighing between...
4. PHARMACOGNOSTIC AND ANTICONVULSANT STUDIES ON GLOSSONEMA BOVEANUM DECNE (APOCYNACEAE)
ABSTRACT
Glossonema boveanum Decne is a hairy canescent perennial herb belonging to the Apocynaceae. Traditionally, the powdered whole plant is use for the treatment of many illnesses including epilepsy. This study is aimed at establishing some of the pharmacognostic features of the pow...
5. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES
Abstract
The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic tech...
6. PHYTOCHEMICAL AND ANTICONVULSANT STUDIES OF METHANOL LEAF EXTRACT OF HYMENOCARDIA ACIDA, TUL (EUPHORBIACEAE)
ABSTRACT
The research was on the phytochemical and anticonvulsant studies of methanol leafextract of Hymenocardia acida, Tul, (Euphorbiaceae) used inNorthern Nigeria for the treatment of headache, rheumatic pain, sickle cell crisis, malaria, epilepsy and cancer. The preliminary phytoche...
7. SOME NEUROPHARMACOLOGICAL STUDIES OF EXTRACT AND FRACTIONS OF CRINUM ZEYLANICUM(L.) (AMARYLLIDACEAE)BULB IN LABORATORY ANIMALS
ABSTRACT
Crinum zeylanicum is a medicinal plant used in folk medicine for management of general debility, infantile seizures and pain. Some neuropharmacological effects of methanolic bulb extract of Crinum zeylanicum were studied in laboratory animals.The Phytochemical screening of the...
8. PHARMACOLOGICAL RATIONALE FOR THE USE OF SOME MEDICINAL PLANTS AS ANTIEPILEPTIC AGENTS IN NIGERIA
ABSTRACT
The effects of the hydro-alcoholic root bark extracts of C. edulis and B. aegyptiaca were studied on pentylenetetrazole (PTZ) and Maximal electroshock (MES)-induced seizures in animal models. The effects of Flumazenil and Naloxone were studied on the anticonvulsant activity of...
