1. ANALGESIC, ANTI-INFLAMMATORY AND TOXICITY STUDIES ON METHANOLIC LEAF EXTRACT OF ROTHMANNIA LONGIFLORA SALISB (RUBIACEAE) IN RATS AND MICE
ABSTRACT
The herbalists in several African Countries have used Rothmannia longiflora decoctions as febrifugal and analgesic agent. The present study examined the analgesic, anti-inflammatory and toxicological profile of the methanolic extract of the plant in experimental animals. The pr...
2. ANTI-DIARRHOEAL AND SUBCHRONIC TOXICITY STUDIES ON METHANOL STEM BARK EXTRACT OF IRIVINGIA WOMBOLU VERMOESEN (IRVINGIACEAE) IN LABORATORY ANIMALS
Abstract
Irvingia wombolu is one of the herbal plants used as food for its nutritional values. It is also used as medicinal plant in the south-south and south-eastern part of Nigeria for the management of diarrhoea and other ailments. Although these medicinal plants are believed to be h...
3. ANTICONVULSANT AND SUB-CHRONIC TOXICITY STUDIES OF THE METHANOL LEAF EXTRACT OF DIOSPYROS MESPILIFORMIS HOCHST (EBENACEAE) IN LABORATORY ANIMALS
ABSTRACT
Diospyros mespiliformis hochst (Ebenaceae) known in English as ebony is a plant that is found throughout West Africa. The Plant was reported to have wide ethnomedical application notably in fever, whooping cough, wounds, pneumonia, syphilis, leprosy and epilepsy among others. T...
4. ANTIDIARRHOEAL AND TOXICITY STUDIES ON METHANOL LEAF EXTRACT OF COMBRETUM HYPOPILINUM DIELS (COMBRETACEAE) IN MICE AND RATS
ABSTRACT
The plant Combretum hypopilinum has been used in traditional medicine to treat diarrhoea and other gastrointestinal diseases. This study aimed to investigate the antidiarrhoeal activity and toxicity profile of the methanol leaf extract of Combretum hypopilinum (MECH) in mice an...
5. ANTIHYPERGLYCAEMIC AND ANTIBACTERIAL EVALUATION OF METHANOL TUBER EXTRACT OF CHLOROPHYTUM ALISMIFOLIUM BAKER (LILIACEAE)
ABSTRACT
Diabetes mellitus is a metabolic disorder which affects about 346 million people globally. Synthetic antidiabetic agents are expensive and also associated with side effects. In a bid to develop cheaper and safer antidiabetic agents, this study was carried out to determine the e...
6. ETHNOBOTANICAL SURVEY OF PLANTS USED IN TREATMENT OF VIRAL INFECTIONS IN JOS, AND ANTIVIRAL EVALUATIONS OF BOSWELLIA DALZIELLI HUTCH (BURSERACEAE) AND ENANTIA CHLORANTHA OLIVER (ANNONACEAE)
ABSTRACT
An ethnobotanical survey of plants used in the treatment of viral infection was carried out in Jos North, Jos South and Jos East Local Government Areas of Plateau State, Nigeria by verbal interactions with Traditional Medicine Practitioners, Herbalist, Herb sellers and some ind...
7. HEPATOPROTECTIVE AND WOUND HEALING PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS PLATYPHYLLA Del. Holl (MORACEA)
ABSTRACT
Ficus platyphylla (Fp) is a medicinal plant that is widely used in Northern part of Nigeria for the management of skin problems such as eczema and topical application of its gum (latex) to wounds. It is also used for treating malaria and psychosis. Its antioxidant, hepatoprotec...
8. PHARMACOGNOSTIC AND ANTIVENIN STUDIES ON LEAVES OF SECURINEGA VIROSA (ROXB EX WILLD) BAILL
ABSTRACT
7 Securinega virosa (Roxb ex Willd) Baill (Euphorbiaceae) is a small, deciduous, graceful shrub that is widely distributed in Africa. It is used to treat snakebites, syphilis, rheumatism and malaria. Plant based medicines are limited in use because of inadequate standardization...
9. PHARMACOLOGICAL INTERACTION BETWEEN ETHANOL EXTRACT OF MORINGA OLEIFERA LEAVES AND METFORMIN IN ALLOXANINDUCED HYPERGLYCAEMIC WISTAR RATS
Abstract
Herbs with anti-diabetic activity could initiate interactions if used concurrently with orthodox drugs. Moringa oleifera is one of such herbs usually taken as an adjunct to orthodox oral hypoglycaemic agents. This study investigated the possible pharmacological interaction betw...
10. PHYTOCHEMICAL AND ANTIVENOM STUDIES ON THE STEM BARK OF ALBIZIA CHEVALIERI HAMS (MIMOSACEAE) ON NAJA NIGRICOLLIS BROADLEY ENVENOMATED MICE
ABSTRACT
Albizia chevalieri Hams (Mimosaceae), mostly found in the Northern Sahel Savannah region of Nigeria as well as in Nigér and Senegal is a tree of the acacia type with a long list of folklore therapeutic claims which include its use as purgative, taenicidal, cough remedy,...
11. SOME NEUROPHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF THE ETHANOLIC LEAF EXTRACT OF CUSSONIA BARTERI SEEMAN (ARALIACEAE) IN LABORATORY ANIMALS
ABSTRACT
Cussonia barteri is used in traditional medicinefor the management of convulsion and epilepsy, especially in children in Ghana and Nigeria. Literature survey revealed that the safety and efficacy of such important medicinal plant have not been scientifically validated. In the p...
12. TOXICOLOGICAL AND ANTI-HYPERGLYCAEMIC PROPERTIES OF AQUEOUS LEAF EXTRACT OF PERSEA AMERICANA MILL (LAURECEAE) IN NORMOGLYCAEMIC AND ALLOXAN-INDUCED HYPERGLYCAEMIC WISTAR RATS
ABSTRACT
Diabetes mellitus has become a global health burden leading to an increase in the search for herbal anti-hyperglycaemic agents as alternative to synthetic ones. Persea americana popularly known as avocado pear have been known for its nutritional and medicinal properties. The le...
13. TOXICOLOGICAL ASSESSMENT OF THE METHANOL LEAF EXTRACT OF SECURINEGA VIROSA(ROXB EX. WILLD) IN WISTAR RATS
ABSTRACT
Securinega virosa is one of the African medicinal plants described as a true “cure all” among traditional practitioners. Different parts of Securinega virosa have been used in the management of different disorders in Nigeria and other parts of the world. There is th...
14. EFFECTS OF CO-ADMINISTRATION OF SITAGLIPTIN AND ETHANOL LEAF EXTRACT OF MORINGA OLEIFERA LAM. IN ALLOXAN-INDUCED DIABETES MELLITUS AND ITS CHRONIC COMPLICATIONS IN RATS
ABSTRACT
Incidence and prevalence of type 2 diabetes mellitus (T2DM), with its resultant complications continue to be on the increase. The outcome of management is highly dependent on efficacy, safety and suitability of medicines used concomitantly. An aspect of efficacy/safety that is...
15. EFFECTS OF DETOXIFICATION ON SOME PHARMACOLOGICAL PROPERTIES OF JATROPHA CURCAS LINN. (EUPHORBIACEAE) SEED OIL IN LABORATORY ANIMALS
Abstract
Jatropha curcas seed oil is a known energy source in biodiesel which but for its toxicity, also has potential of being used as food and in the pharmaceutical / cosmetic industries. This study was designed to detoxify solvent and mechanically extracted J. curcas oils and to asce...
16. HAEMATOLOGICAL, SERUM BIOCHEMICAL AND PATHOLOGICAL CHANGES IN JAPANESE QUAIL (COTURNIX COTURNIX JAPONICA) EXPERIMENTALLY INFECTED WITH SALMONELLA ENTERICA SEROVAR GALLINARUM
ABSTRACT
A total of 160 (108 males and 52 females) Japanese quails (Coturnix coturnix japonica) were used for the experiment. The quails were obtained at the age of four weeks from the Poultry Unit of the National Veterinary Research Institute, Vom, Plateau State, Nigeria. They were ran...
17. PHARMACOGNOSTIC, NUTRITIONAL AND TOXICITY STUDIES ON THE AERIAL PART OF DAUCUS CAROTA L. (APIACEAE)
Abstract
Daucus carota (L.) commonly known as carrot belongs to the family of Apiaceae. The aerial part is used as component of livestock feed in some part of Northern Nigeriawithout any scientific evidence ofsafety. The present study was carried out to establish its pharmacognostic, nu...
18. PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF THE METHANOL EXTRACT OF ACACIA ATAXACANTHA LEAF D.C. (LEGUMINOSAE) IN MICE AND RATS
ABSTRACT
Acacia ataxacantha is used in traditional medicine for management of pain and inflammation. Literature survey revealed that the safety and efficacy of such uses have not been scientifically validated. The present study was designed to study the pharmacological and toxicological...
19. THE EFFECT OF MEFLOQUINE CHEMOPROPHYLAXIS ON THE OUTCOME OF PREGNANCY IN WOMEN OF LOW AND HIGH PARITY IN NIGERIA
ABSTRACT
Malaria accounts for 25% -70% of infant, 30% of under- five and 7% -11% of maternal mortality in Nigeria. The World Health organization recommended malarial drug prophylaxis for pregnant women in malaria endemic areas to prevent the adverse consequences of malaria in pregnancy....
20. TOXICITY STUDIES OF THE ETHANOLIC STEM BARK EXTRACT OF RANDIA NILOTICA STAPF. IN RATS
ABSTRACT
The use of medicinal plant extracts to maintain health, prevent or cure various diseases is known since ancient times. However, most times, there is little or no knowledge of the associated possible toxic injuries on vital organs morphology or functions from the use of such pla...
21. EFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICE
ABSTRACT
Malaria is the 2nd leading cause of death from infectious diseases in Africa, after HIV/AIDS. It is a major public health problem in Nigeria where it accounts for most cases of hospital visits and deaths than any other country in the world. This study evaluated the effects of c...
22. PHARMACOGNOSTIC AND BIOLOGICAL STUDIES OF THE LEAVES AND STEM-BARK OF HYMENOCARDIA ACIDA, TUL. (EUPHORBIACEAE)
ABSTRACT
This study deals with the pharmacognostic and biological aspects of the leaves and stem bark of Hymenocardia acida Tul (Family Euphorbiaceae). Euphorbiceae is a large and heterogeneous family found mainly in the tropics and sub-tropics. H. acida is a savannah shrub or tree with...
23. SOME NEUROPHARMACOLOGICAL STUDIES OF EXTRACT AND FRACTIONS OF CRINUM ZEYLANICUM(L.) (AMARYLLIDACEAE)BULB IN LABORATORY ANIMALS
ABSTRACT
Crinum zeylanicum is a medicinal plant used in folk medicine for management of general debility, infantile seizures and pain. Some neuropharmacological effects of methanolic bulb extract of Crinum zeylanicum were studied in laboratory animals.The Phytochemical screening of the...
24. HISTOPATHOLOGICAL EVALUATION OF GYNAECOLOGICAL BIOPSIES FROM PATIENTS ATTENDING THE BRAITHWAITE MEMORIAL SPECIALIST HOSPITAL, RIVERS STATE
STATEMENT OF THE PROBLEM
The recent alarm on rising global incidence of biopsies by the World Health Organisation (WHO) should worry areas prone to gynaecological biopsies. Cancer killed 7.6 million persons in 2008 worldwide, and there is indication that the figure could double to 13 mi...
25. EFFECT OF IONIZING RADIATION ON THE KIDNEY (A CASE STUDY OF WINTER RAT)
Background of the study
The effect of ionizing radiation on biological systems has been a subject of extensive research, particularly concerning its implications on various organs within the body. Among these organs, the kidney holds significant importa...
26. CHRONIC TOXICITY EXTRACTION OF AFRICAN MESQUITE TREE PART EXTRACT IN RAT
ABSTRACT
This study investigated the chronic toxicity of African Mesquite tree (Prosopis africana) extracts in Wistar rats, focusing on biochemical, hematological, and histopathological effects. The extracts were administered at doses of 100 mg/kg, 300...
