1. DESIGN AND DEVELOPMENT OF A STARCH-BASED MULTIFUNCTIONAL EXCIPIENT (STARGELASIL) FOR TABLET FORMULATION
ABSTRACT
The concept of co-processing as a particle engineering technique has been used as a tool to improve the functionality of many existing excipients. This study was designed to improve the functionality of cassava starch as excipient for direct compression by coprocessing with gel...
2. EVALUATION OF MODIFIED STARCHES AND MUCILAGE DISPERSIONS OBTAINED FROM IPOMOEA BATATAS L. LAM (CONVOLVULACEAE) AS BULK EXCIPIENTS IN CHEWABLE TABLET FORMULATIONS
ABSTRACT
Increasing attention has been paid to incorporating hydrocolloids into starch-based products due to their unique functional properties and bio-safety. The aim of this work was to determine the suitability of modified starch and mucilage dispersions obtained from Ipomoea batatas...
3. EVALUATION OF TABLETING AND COMPRESSIONAL CHARACTERISTICS OF NATIVE AND MICROCRYSTALLINE STARCHES DERIVED FROM DIGITARIA IBURUA
ABSTRACT
Acid hydrolyzed starch produces microcrystalline starch (MCS) with improved functional properties in terms of flowability or compressibility. The aim of this study was to investigate the binder, disintegrant and compressional properties of native and modified starches derived f...
4. EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT
ABSTRACT
The aim of this research was to study the tableting properties of Solenostemon rotundifolius starch (SRS) and modified forms for use as pharmaceutical excipient by wet granulation method of tablet production in paracetamol formulation. The physicochemical properties of native a...
5. PHYTOCHEMICAL, PHARMACOLOGICAL AND FORMULATION STUDIES OF Andrographis paniculata Nee Acanthacae
ABSTRACT
The leaves of Andrographis paniculata acanthaceae is used locally in Northern Nigerian for the treatment of hypertension without quantification or dosage standardization. This work was primarily set out to find justification for the local medicinal use of this plant and to scie...
6. SURFACE ACTIVITY AND RELEASE PROPERTIES OF SOME TROPICAL GUMS IN ARTEMETHER AND ARTESUNATE SODIUM TABLET FORMULATIONS
ABSTRACT
Plant gums are natural polymers with low toxicity, high biodegradability and high compatibility with drugs making them useful as pharmaceutical excipients in solid, semi-solid and liquid formulations. This work was aimed at evaluating the surface activity and release properties...
7. EVALUATION OF CHRYSOPHYLLUM ALBIDUM (G. DON) FRUIT GUM AS A SUSTAINED RELEASE MATRIX IN TABLET FORMULATIONS
ABSTRACT
The goal of designing sustained release or controlled release delivery system is to reduce the frequency of dosing or to increase effectiveness of the drug by localization at the site of action, reducing the dose required or providing uniform drug delivery. Natural gums and pol...
8. EVALUATION OF MODIFIED FINGER MILLET STARCH (Eleusinecoracana L.) AS FILLER/BINDER IN DIRECT COMPRESSION
ABSTRACT
Starch modifications are a means of altering the structure and affecting the hydrogen bonding in a controllable manner to enhance and extend their application. There are different methods for modification of starch such as chemical modifications which include stabilization, cro...
9. EVALUATION OF THE BINDING AND SUSPENDING PROPERTIES OF BAGGASE-DERIVED METHYLCELLULOSE
ABSTRACT
Sourcing of raw materials for use in pharmaceutical industries is a continuing challenge. Excipients, which form the bulk of a dosage form, are derived either from natural sources or synthesized wholly or semi-synthesized. The absence of an ideal excipient material continues to...
10. DEVELOPMENT AND EVALUATION OF A CO-PROCESSED EXCIPIENT FROM ACID HYDROLYZED CASSAVA STARCH, GELATIN AND LACTOSE (STARGELAC) IN TABLET FORMULATIONS
ABSTRACT
Co-processed excipients are a mixture of two or more existing excipients at subparticle level. These multipurpose excipients have significantly reduced the number of incorporating excipients in the tablet. The aim of this work is to design and prepare a coprocessed excipient fr...
11. DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF RISPERIDONE IN PURE AND TABLET DOSAGE FORMS
ABSTRACT
Two simple, sensitive, accurate and extraction-free spectrophotometric methods were developed and described for the determination of risperidone in pure and in tablet dosage forms. The methods are based on the formation of ion-pair complex between risperidone and the dyes bromo...
12. DEVELOPMENT OF A FILLER-BINDER DISINTEGRANT FOR DIRECT COMPRESSION TABLETING BY CO-PROCESSING MICROCRYSTALLINE CELLULOSE AND CROSPOVIDONE
ABSTRACT
The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to o...
13. EVALUATION OF A CO-PROCESSED EXCIPIENT FROM COW BONE POWDER AND GELATIN FOR USE IN DIRECT COMPRESSION TABLETING
ABSTRACT
The objective of the study was to develop an excipient consisting of cow bone powder and gelatin by the co-processing method and to evaluate its use in direct compression tablet formulation. Co-processing is based on the novel concept of two or more excipients interacting at th...
14. FORMULATION STUDIES OF ACACIA SIEBERIANA GUM IN CHOROQUINE AND METRONIDAZOLE MATRIX TABLETS
ABSTRACT
The crude plant gum from African Acacia sieberiana was purified and investigated for use as a matrix excipient for chloroquine phosphate and metronidazole tablet formulations. The chromatographic analysis of the acid hydrolysed gum revealed the presence of rhamnose, galactose,...
15. ANTIDIABETIC PROPERTIES OF MUCUNA PRURIENS L. (D.C.) SEED EXTRACT AND ITS TABLET FORMULATIONS
ABSTRACT
Diabetes mellitus and its complications continue to be one of the highest causes of morbidity and mortality in recent times. Although many drugs are commercially available for use in the management of diabetes, their side effects and high costs underscore the need for new drugs...
