1. ANTICONVULSANT STUDIES OF THREE SYNTHESIZED DICHLOROSUBSTITUTED PHENYL PROPANAMIDES AND THEIR ACTION ON VOLTAGE-GATED SODIUM CHANNELS (Nav1.6)
Abstract
The field of antiepileptic drug development has become dynamic, affording many promising research opportunities. Continued efforts are being made in the development of antiepileptic drugs employing a range of strategies, including modification of the structures of existing drug...
2. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3 ISOMERS OF 4-[(DIMETHYLPHENYL)AMINO]-4-OXOBUTENOIC ACID
ABSTRACT
Epilepsy is a disorder of public concern worldwide and has been widely treated via pharmacotherapy, which are faced with challenges such as cost of therapy, side effects, toxicity and lack of selectivity. As such, researchers agree on the need to identify more selective, readil...
3. PHARMACOLOGICAL RATIONALE FOR THE USE OF SOME MEDICINAL PLANTS AS ANTIEPILEPTIC AGENTS IN NIGERIA
ABSTRACT
The effects of the hydro-alcoholic root bark extracts of C. edulis and B. aegyptiaca were studied on pentylenetetrazole (PTZ) and Maximal electroshock (MES)-induced seizures in animal models. The effects of Flumazenil and Naloxone were studied on the anticonvulsant activity of...
4. PHYTOCHEMICAL AND ANTICONVULSANT STUDIES ON METHANOL EXTRACT OF THE ROOTBARK OFUVARIA CHAMAEP. BEAUV. (ANNONACEAE)
ABSTRACT
Uvariachamae P. Beauv. (Annonaceae) is widely distributed inAfrica, the plant species are used in traditional medicine as an anti-inflamatory, antimalarial, and analgesic. It is also used for treatment of jaundice, epilepsy and microbial infections. The powdered rootbark of U.c...
