MODULATORY EFFECT OF METFORMIN AND ARTEMETHER-LUMEFANTRINE ON BLOOD COAGULATION IN DIABETIC MICE CO-INFECTED WITH MALARIA
- Project Research
- 1-5 Chapters
- Qualitative
- Library / Doctrinal
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Blood coagulation is a process describing conversion of soluble materials within the blood into an insoluble gel that plugs injury/break site within blood vessels; this process requires regulation. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, defectiveness of insulin hormone has been found to have an increased risk of coagulation and can lead to cardiovascular disorders. Malaria is a disease caused by plasmodium parasite, when the parasite enters the bloodstream; proteins are secreted into the host’s red blood cells, which stick to other blood cells making them adherent to blood vessel walls reducing detection and destruction of infected blood cells by the immune system which potentially causes blood clots. Effect of anti-malaria drugs on blood coagulation has not been properly investigated, as diabetics have been found to have possible co-infection with malaria, this study aims to provide information on the modulation of blood coagulation by metformin and artemether-lumefantrine in diabetic mice co-infected with malaria.
Fifty albino mice (BALB/C strain) were divided into 8 groups for this study; group I served as the normal control, group II served as diabetes negative control, group III served as malaria only, group IV served as diabetes co-infected with malaria group, group V served as malaria treated with 6.86 mg/body weight of artemether-lumefantrine, group VI served as diabetes treated with 200 mg/body weight of metformin, group VII served as diabetes co-infected malaria and treated with 200 mg/body weight of metformin and group VIII served as diabetes co-infected with malaria and treated with 200 mg/body weight of metformin and 6.86 mg/body weight of artemether-lumefantrine.
The results showed artemether-lumefantrine having an anti-coagulant effect on prothrombin time of extrinsic factors in malaria positive treatment group, metformin having a pro-coagulant effect on intrinsic factors in diabetes positive control group, and artemether-lumefantrine elevating the fibrinogen concentration in malaria positive control group. These findings suggest that while metformin is the first-line drug with an anti-coagulant effect on diabetes, artemether-lumefantrine not only could cure plasmodium falciparum but also possesses an anticoagulant effect.
Keywords: Artemether-Lumefantrine, Blood coagulation, Diabetes, Malaria, Metformin
Related Project Materials
THE INFLUENCE OF CELEBRITY ACTIVISM ON POLITICAL MOVEMENTS IN NIGERIA (A CASE STUDY OF ENDBADGOVERNANCE PROTEST IN NIGERIA)
THE INFLUENCE OF CELEBRITY ACTIVISM ON POLITICAL MOVEMENTS IN NIGERIA (A CASE STUDY OF ENDBADGOVERNANCE PROTEST IN NIGERIA)
Indigenous arts in Nigeria are as old as time imm...
Abstract: Innovations in vocational training for emerging technologies such as AI and IoT a...
Abstract Domestic violence and it effect on national security which is any act of gender-based violence that results in...
Background Of The Study Internet technologies have impacted how individuals generate and distribu...
Background Information Mass media messages are often referred to those directed at a large group of per...
ABSTRACT The Internet of Things (IoT) is converting the agriculture industry and solving the immense problems or the maj...
ABSTRACT This study was carried out on impact of staff training and development on employees performanc...
ABSTRACT This research work was designed to determine the role of small and medium enterprise in the socio-econom...
BACKGROUND OF THE STUDY The process of moving raw materials and completed commodities from the site of production to th...
OIL-PALM PRODUCTION IN EJIGBO COMMUNITY IN OSUN STATE, 1960-2000
INNOVATIONS IN VOCATIONAL TRAINING FOR EMERGING TECHNOLOGIES (E.G., AI, IOT)
DOMESTIC VIOLENCE AND IT EFFECT ON NATIONAL SECURITY
PERCEPTION OF UNDERGRADUATE STUDENTS IN NIGERIAN UNIVERSITIES ABOUT WHATSAPP SOCIAL MEDIA AS A TEACHING AND LEARNING TOOL
AUDIENCE PERCEPTION OF THE ROLE OF SPORT JOURNALISM IN SPORT DEVELOPMENT IN NIGERIA
DESIGN AND IMPLEMENTATION OF A SOIL MOISTURE DETECTOR WITH AUTOMATIC SMS NOTIFICATION SYSTEM
IMPACT OF STAFF TRAINING AND DEVELOPMENT OF EMPLOYEES PERFORMANCE IN NIGERIA. (A CASE STUDY OF NIGERIAN BOTTLING COMPANY)
THE ROLE OF SMALL SCALE ENTERPRISES IN THE SOCIO-ECONOMIC DEVELOPMENT OF THE RURAL AREAS
AN INVESTIGATION ON THE EFFECT OF LOGISTICS MANAGEMENT IN MARKETING OF AGRICULTURAL PRODUCTS (A STUDY OF DIVERSAY SOLUTION LIMITED)
