0704-883-0675     |      dataprojectng@gmail.com

ANTIDIABETIC PROPERTIES OF MUCUNA PRURIENS L. (D.C.) SEED EXTRACT AND ITS TABLET FORMULATIONS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

Diabetes mellitus and its complications continue to be one of the highest causes of morbidity and mortality in recent times. Although many drugs are commercially available for use in the management of diabetes, their side effects and high costs underscore the need for new drugs. Mucuna pruriens (L.) DC. (Fabaceae) is among the plants used in the management of diabetes in the tropics. The antidiabetic and ameliorative effects of the seed ethanolic extract of M. pruriens on alloxan-induced diabetes in Wistar rats were evaluated. Antidiabetic activity of the formulated M. pruriens tablets was also investigated in rabbits. Preliminary phytochemical screening of M. pruriens was done using standard methods. The effects of oral administration of the extract at doses 5.0-100.0 mg/kg body weight (bw) and glibenclamide (5.0 mg/kg bw) as standard drug were studied in alloxaninduced (120 mg/kg, i.p) diabetic rats (eight groups of six rats each, plasma glucose>450.0 mg/dL). Biochemical parameters were evaluated by spectroscopy and acute toxicity tests carried out based on mortality rate of Swiss albino mice. Tablets were formulated using direct compression and wet granulation methods. Mechanical properties of the tablets were assessed using crushing strength, friability and the crushing strengthfriability ratio while drug release properties were evaluated by determining disintegration and dissolution times. The in vivo release properties of selected tablet formulations in diabetic rabbits were assessed. Data were analyzed using descriptive statistics, linear regression and ANOVA. The seed of M. pruriens contained alkaloids, saponins, steroids and phenols. The administration of 5.0, 10.0, 20.0, 30.0, 40, 50.0, and 100.0 mg/kg of the crude ethanol extract of MP led to 18.6%, 24.9%, 30.8%, 41.4%, 49.7%, 53.1% and 55.4% reduction, respectively in blood glucose level eight hours after administration, while glibenclamide resulted in 59.7% reduction. Chronic administration of the extract also resulted in significant (p<0.001) dose-dependent reduction in the blood glucose level and the alleviation of body weight loss associated with diabetes. Acute toxicity tests showed that no death was recorded after administration of the extract (0.5 – 32.0 g/kg). Significantly (p<0.05) elevated levels of plasma cholesterol, triglycerides, urea, creatinine, aspartate aminotransferase and alanine aminotransferase with concomitant decrease in total protein level were observed in diabetic rats when compared with control rats. The values of these biochemical parameters were restored to normal levels by M. pruriens extract or glibenclamide after 12 weeks of treatment. Mucuna pruriens tablets prepared by wet granulation exhibited higher mechanical and drug release properties than tablets prepared by direct compression (p<0.05). The tablet properties depended on the type and concentration of binders and excipients employed in the formulations. Tablets prepared by direct compression showed better reduction in the blood glucose level, compared to those prepared by wet granulation. There was a direct correlation between drug released from the tablets in vitro and its antidiabetic activity in vivo in rabbits (r 2 = 0.995). The ethanolic extract of the seed of Mucuna pruriens and its tablet formulations showed significant antidiabetic activity. In addition, M. pruriens displayed both hepatoprotective and cholesterol reducing properties in diabetic rats.




FIND OTHER RELATED TOPICS


Related Project Materials

AN ASSESSMENT OF SOCIO-ECONOMIC CONSEQUENCES OF BOKO HARAM TERRORISM IN MUBI-METROPOLIS OF ADAMAWA STATE (2011-2015)

ABSTRACT

Terrorism constitute serious threats to Nigeria‘s security, affecting not only Nigeria‘s sovereignty, law and order,...

Read more
PROFESSIONAL ETHICS IN SECRETARIAL PRACTICE AND THE LEVEL OF JOB PERFORMANCE OF SECRETARIES

ABSTRACT

This research project was carried out using The Polytechnic Ibadan, Adeseun Ogundoyin Campus,...

Read more
IMPORTANCE OF DICTION IN NEWSCASTERS IN DELIVERING EFFECTIVE NEWS AND PROGRAMMES TO THE AUDIENCE

ABSTRACT

The primary objective of this study is to investigate the significance of diction employed by...

Read more
INVESTIGATION OF THE EFFECT OF MOULDING SAND (NATURAL & SYNTHETIC) ON CASTING OF FLANGE USING ALUMINIUM

Read more
AN ASSESSMENT OF PUBLIC SECTOR FINANCIAL MANAGEMENT AND ACCOUNTABILITY

AN ASSESSMENT OF PUBLIC SECTOR FINANCIAL MANAGEMENT AND ACCOUNTABILITY

ABSTRACT

 

This study assesses public sec...

Read more
AN EVALUATION OF ROLE OF THE MEDIA AND NATIONAL SECURITY IN NIGERIA

EXCERPT FROM THE STUDY

The Nigerian media has great responsibility to set public agenda that will enhance the realization of good life in...

Read more
THE IMPACT OF CHILD ABUSE ON THE ACADEMIC PERFORMANCE OF STUDENTS IN JUNIOR SECONDARY SCHOOL

Abstract

The research work aimed to look at the impact of child abuse on the academic performance of junior student in s...

Read more
ASSESSMENT OF COMMUNITY PARTICIPATION IN RURAL DEVELOPMENT PROJECTS

ABSTRACT

The study sought to evaluate the challenges and opportunities for effective community participation in rural de...

Read more
THE EFFECTS OF ORGANIZATIONAL CULTURE ON EMPLOYEE PERFORMANCE AND PRODUCTIVITY

ABSTRACT

This study examines the effect of organizational culture on employee performance and organizational productivit...

Read more
THE EFFECT OF HUNGER ON LEARNING CAPABILITY OF PRIMARY SCHOOL PUPILS IN EDO STATE

ABSTRACT

The main objective of this study it to examine  the effect of hunger on learning cap...

Read more
Share this page with your friends




whatsapp