PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON THE LEAF EXTRACT OF STEREOSPERMUM KUNTHIANUM (BIGNONIACEAE)
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Stereospermum kunthianum (Bignoniacea) herb is used in Hausa ethnomedicine in treating bronchitis, veneral diseases, diarrheoa and dysentery. It is also used in the treatment of ulcers, leprosy, skin eruptions, respiratory ailments and gastritis. The plant is common in Northern Nigeria where it is used as abortifacient and as antihypertensive agent. General phytochemical investigation of both petroleum ether and ethanolic extracts of the leaves of Stereospermum, kunthianum revealed the presence of sterol/triterpenes, coumarin, fatty acids while flavones and alkaloids were absent. In the ethanolic extract, sterols/triterpenes saponins, tannins, coumarins and free carboxylic acids were found to be present. Extensive phytochemical, chromatographic and physiochemical and spectroscopic investigation of the petroleum ether extract of the leaves of Stereospermum kunthianum using column chromatography on silica-gel with gradient elution afforded methyl-1-undecyl-2, 3, 3a, 5a, 6, 7, 8, 9, 9a 10, 11, 11a- dodecahydro-IH-cyclopenta[a] phenanthrene -4-carboxy. The structure was established by elemental analysis and the use of ACD/ NMR Assistant (a computer software). Library search and computer interpretation of the 1HNMR spectrum obtained support the molecula formular of the compound as C30 H48O2. viii Pharmacological studies of the n-butanol extract on isolated rabbit jejunum showed a dose-dependent relaxation of the tissue. The acute toxicity test for the extract in mice established an intraperitioneal LD50 of 3,807.9mg/kg. In castor oil-induced diarrhoea, 60% protection was observed at doses of 500mg/kg and 1000mg/kg respectively. The plant extract exhibited antidiarrheoal activity that was comparable to that of Loperamide 5mg/kg. The result revealed that the extract have pharmacological activity against diarrheoa, this suggests some traditional claims of the plant.
Related Project Materials
AN EXAMINATION ON THE CAUSES OF EMPLOYEE DISENGAGEMENT
BACKGROUND OF THE STUDY
Employee disengagement is one very serious unnerving issue that results in anxi...
AWARENESS AND UTILIZATION OF ONLINE PUBLIC ACCESS CATALOGUE (OPAC) BY UNDERGRADUATE STUDENTS IN FEDERAL UNIVERSITY DUTSINMA LIBRARY, KATSINA STATE, NIGERIA
ABSTRACT
OPAC refers to information retrieval system composed of database of bibliographic records describing the books and other materia...
PROMOTING INTERDISCIPLINARY APPROACHES IN TECHNICAL EDUCATION
Abstract: This study promotes interdisciplinary approaches in technical education in Nigeri...
IMPACT OF ADULT EDUCATION ON EMPOWERING MARGINALIZED COMMUNITIES
Abstract: The topic of this research is the impact of adult education on empowering marginalized communities. The study aimed to explore how a...
THE EFFECTIVENESS OF E-LEARNING PLATFORMS IN TECHNICAL EDUCATION
ABSTRACT: This study explores the effectiveness of e-learning platforms in technical education, focusing on their impact on student engagement...
INFLUENCE OF SINGLE PARENTING ON THE ACADEMIC PERFORMANCE OF SECONDARY SCHOOL STUDENTS IN OBIO OKPOI LGA OF RIVER STATE
ABSTRACT
This study attempted to investigate the effects of single-parenthood on the academic performance of secondary...
DESIGN AND IMPLEMENTATION OF A COMPUTER BASED HUMAN RESOURCES MANAGEMENT INFORMATION SYSTEM (A CASE STUDY OF NITEL PLC ENUGU)
ABSTRACT
The current and future well-being of an organization dep...
AN ASSESSMENT OF BANK INSPECTION AND ENFORCMENT OF BANKING REGULATION IN ZENITH BANK, UBA OR FBN ETC
Background of the study
In a banking environment that is becoming increasingly competitive, which is characterized by fr...
THE COMPARATIVE STUDY OF THE PERFORMANCE OF GOVERNMENT OWNED AND PRIVATELY OWNED BROADCASTING MEDIA ORGANIZATION
ABSTRACT
This project examines the comparative study of the performances of government owned and privately owned broad...
AN ASSESSMENT OF THE EFFECT OF ENDBADGOVERNANCE PROTEST ON NIGERIA ECONOMIC ACTIVITIES
AN ASSESSMENT OF THE EFFECT OF ENDBADGOVERNANCE PROTEST ON NIGERIA ECONOMIC ACTIVITIES
Chapter One...
