0704-883-0675     |      dataprojectng@gmail.com

PHARMACOLOGICAL EVALUATION OF THREE LOCALLY USED MEDICINAL PLANTS AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

Drugs from plant and animal sources are increasingly becoming important in the therapeutic management of liver diseases. This study was undertaken to evaluate the prophylactic and curative effects of methanolic extracts of Balanites aegyptiaca root, Boswellia dalzielii stem bark, Ipomoea asarifolia leaves and their mixture against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Liver damage was induced by intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (99.9% CCl4) in olive oil (1:1), on alternate days, over a period of 5 days. The degree of liver damage was determined by assessing changes in hepatic indices such as serum levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, triglycerides, cholesterol, total and direct bilirubin; pentobarbitone sleeping time; liver weight and histopathology. The mixture (160 mg B. aegyptiaca, 220 mg B. dalzielii and 300 mg/kg I. asarifolia) and each dose of the various extracts 100 mg, 200 mg and 400 mg/kg of B. aegyptiaca, B. dalzielii and I. asarifolia were administered orally once daily for 7 days prior to administration of CCl4 (prophylactic study) and after the administration of CCl4 (curative study). The degree of recovery and/or prevention of liver pathology were estimated by comparing changes in hepatic indices with that of the standard drug, silymarin (100 mg/kg). Oral LD50 of each extract was found to be above 2000 mg/kg (OECD-423). Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenes, sterols, resins and volatile oils in each of the extracts. Pretreatment with each extract significantly (P<0.05) prevented carbon tetrachloride-induced changes in hepatic indices, liver weight and histopathology compared to control. When compared to the positive control (silymarin 100 mg/kg), the protective effect of the extracts was superior and significant (P<0.05) at the doses of 400 mg/kg (B. aegyptiaca), 100 mg/kg (B. dalzielii) and 200 mg/kg (I. asarifolia). In the evaluation of the curative effect of the ix various plant extracts alone (all doses of B. aegyptiaca, 100 mg and 200 mg/kg each of B. dalzielii and I. asarifolia) or in combination (160 mg B. aegyptiaca, 220 mg B. dalzielii and 300 mg/kg I. asarifolia), the extracts significantly (P<0.05) reversed the CCl4 -induced liver pathology as seen in the values of the hepatic indices, liver weight and histopathology. This effect was comparable with that of silymarin. Prophylactic treatment with B. aegyptiaca, B. dalzielii and the mixture produced significant increases in pentobarbitone sleeping time while I. asarifolia decreased the sleeping time when compared to the control. Curative studies revealed a significant (P<0.05) decrease in sleeping time following treatment with all the extracts. These results indicate that methanolic extracts of B. aegyptiaca, B. dalzielii and I. asarifolia are relatively safe orally and possess potent hepatoprotective properties that may be useful in the management of liver diseases.




FIND OTHER RELATED TOPICS


Related Project Materials

DESIGN AND IMPLEMENTATION OF PASSWORD BASED ACCESS CONTROL WITH INTRUDER ALERT SYSTEM

ABSTRACT

The necessity of a low cost electronic home security system designed in co-ordination with other security measu...

Read more
THE PROBLEMS AFFECTING TERTIARY INSTITUTIONS IN NIGERIA (A CASE STUDY OF COLLEGE OF EDUCATION EKIADOLOR- BENIN CITY

ABSTRACT

The aim of this study was to examine the problems of tertiary institutions in Nigeria...

Read more
SERUM LIPID PROFILE OF AFRICA MESQUITE TREE PART EXTRACT IN RAT

ABSTRACT

This study investigates the lipid-modulating effects of extracts from different parts of the A...

Read more
EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT

ABSTRACT

The aim of this research was to study the tableting properties of Solenostemon rotundifolius starch (SRS) and modified forms for...

Read more
CAUSES AND CONSEQUENCES OF DIVORCE ON NEWLY MARRIED COUPLES

ABSTRACT

Marriage is an institution whereby men and women are joined in a special kind of social and le...

Read more
ASSESSMENT OF THE STRATEGIES FOR CULTIVATING ENVIRONMENTAL AWARENESS THROUGH EARLY CHILDHOOD EDUCATION (ECE) PROGRAMS IN NIGERIA

Abstract: This study examines strategies for cultivating environmental awareness through early childhood edu...

Read more
THE ROLE OF MANAGEMENT DISCRETION IN FINANCIAL REPORTING

Abstract:

This research explores the role of management discretion in financial reporting in Lagos Stat...

Read more
A SURVEY ON THE MISMANAGEMENT AND EMBEZZLEMENT OF PUBLIC FUND AND ITS IMPACTS ON GOVERNMENT PARASTATALS (A CASE SYTUDY OF FIRS, ABUJA)

Background to the study

Financial misappropriation is gaining attention throughout the world, with many...

Read more
ADEQUACY OF FUNDING AND GROWTH OF SMALL AND MEDIUM ENTERPRISES (SMEs) IN NIGERIA

ABSTRACT

The study examined the adequacy of funding and growth of small and medium enterprises (SMEs) in Nigeria. The cross-sectional res...

Read more
COMMUNICATION AS INDISPENSABLE TOOL FOR EFFECTIVE ADMINISTRATION

Abstract

Every activity in an organization requires human beings to interact, exchange information and co-ordinate other...

Read more
Share this page with your friends




whatsapp