0704-883-0675     |      dataprojectng@gmail.com

PHYTOCHEMICAL AND ANTI-INFLAMMATORY STUDIES ON THE HEXANE EXTRACT OF THE STEM BARK OF STEGANOTAENIA ARALIACEAHOSCHTS (APIACEAE)

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

Inflammation has been implicated in virtually all human and animal diseases. It has become the focus of global scientific research, more so, since the currently used anti-inflammatory agents both steroidal and non-steroidal are prone to evoking serious adverse reactions. Steganataeniaaraliacea(Apiaceae)stem bark has been reported to be used in traditional medicine for the treatment of asthma and rheumatism in East Africa. In this study, thehexane extract of the stem bark of the plant was evaluated for its anti-inflammatory property and with a view to isolating bioactive compounds from it.Methods for evaluating macroscopical features and physico-chemical properties were used for the pharmacognostic studies on the stem bark, chromatographic techniques including the thin layer chromatography (TLC) and column chromatography using silica gel were used for the phytochemical studies on the hexane extract of the plant while the anti-inflammatory study was also carried out on the hexane extractusing formalin induced paw oedema in rats. The macroscopical features of the whole stem bark was described as yellowish-green in colour, waxy and short fractured with an aromatic odour while the powdered stem bark was described as brown in colour, aromatic in odour with a sweet bitter taste. The physico-chemical properties of the bark determined include total ash value 10.67%, acid-insoluble ash value 4.00%, water-soluble ash value 1.25%, moisture content 8%, watersoluble extractive value 2.87%, alcohol-soluble extractive value 6.67% and petroleum ethersoluble extractive value 1.27%. The TLC profiling of the hexane extract of the bark showed the presence of steroids/terpenes. The column chromatography of the hexane extract of the stem bark lead to isolation of Compound UF which was characterized using the 1H-NMR spectroscopy and its physical properties. Compound UF was identified as Hentriacotane (C31H64) based on the available spectroscopic data and physical properties which agreed well with those reported in the viii literature. The acute toxicity studies of the hexane extract revealed (LD50) of 282.84mg/kg suggesting the extract is moderately toxic. The effect of the hexane extract on formalin induced paw oedema in rats revealed a dose dependant inhibition of the paw oedema when compared to the reference. The concentrations of the extract at 35, 70 and 140 mg/kg of the extract showed 41%, 42% and 50% inhibition respectively at the peak of the paw oedema which were statistically significant at P<0.05. This indicates a dose dependent anti-inflammatory activity of the extract.




FIND OTHER RELATED TOPICS


Related Project Materials

THE UNITED STATES OF AMERICA AND THE WAR AGAINST INTERNATIONAL TERRORISM: ANALYSIS OF THE INVASION OF IRAQ

ABSTRACT

This study takes a critical examination of the United States posture against international terrorism and eventu...

Read more
THE ROLE OF EARLY CHILDHOOD EDUCATION IN FOSTERING INTERGENERATIONAL RELATIONSHIPS

 ABSTRACT: The role of early childhood education in fostering interge...

Read more
UNDERGRADUATE SOCIAL STUDIES STUDENTS’ PERCEPTION OF POLITICAL SOCIALIZATION FOR MOBILIZATION AND PARTICIPATION IN DEMOCRATIC PROCESS IN NIGERIA

ABSTRACT

This study was designed to assess the undergraduate Social Studies students‟ perception of Political Socialization for mobilizat...

Read more
AE-FUNAI UNDERGRADUATES STUDENT AWARENESS AND PERCEPTION OF POLICE BRUTALITY IN NIGERIA

BACKGROUND OF THE STUDY

The police are state personnel who are in charge of 'law enforcement and or...

Read more
DEVELOPMENT OF REAL-TIME, SOLAR POWERED MICROCONTROLLER-BASED WEATHER STATION FOR THE ACQUISITION OF ATMOSPHERIC PARAMETERS

ABSTRACT

Atmospheric researchers, meteorologists, and farmers continue to face difficulties in assessing real-time weather data. This pro...

Read more
ELECTION VIOLENCE AND DEMOCRACTICS STABILITY IN NIGERIA

Abstract

This study is on election violence and democratic stability in Nigeria. The total population for the study is 2...

Read more
ASSESSMENT OF MOTIVATION AS A MANAGEMENT STRATEGY FOR PRODUCTIVITY OF CONSTRUCTION PROJECTS IN ABUJA, NIGERIA.

ABSTRACT

Human resource is the livewire of any organisation. Its effective management is very crucial and central in the achievement of o...

Read more
THE ROLE OF THE WORLD TRADE ORGANISATION IN RESOLVING TRADE DISPUTES UNDER INTERNATIONAL LAW

ABSTRACT

In 1995, the World Trade Organisation (WTO) was established as the only international Organisation dealing with the global rules...

Read more
THE ROLE OF FUND ACCOUNTANTS IN COMPLIANCE AUDITS

ABSTRACT

 

THE ROLE OF FUND ACCOUNTANTS IN COMPLIANCE AUDITS is the focus of this study, with objectives to examine their...

Read more
IMPACT OF SOCIAL MEDIA ON CONSTRUCTION SMEs BUSINESSES IN ABUJA

ABSTRACT

Since the advent of social media in the early 2000s, its influence on the day to day life of people has impacted the way they co...

Read more
Share this page with your friends




whatsapp