0704-883-0675     |      dataprojectng@gmail.com

EVALUATION OF THE DISSOLUTION AND OTHER CHARACTERISTICS OF CYCLODEXTRIN MOLECULAR INCLUSION COMPLEXES OF ARTEMETHER

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-β-cyclodextrin. The solid complexes of artemether and hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared at a molar ratio of 1:1, 1:2 and 1:3 by kneading method. The effect of HP-β-CD on the aqueous solubility and dissolution rate of artemether was investigated through phase solubility analysis and in-vitro dissolution studies. The formation of inclusion complexes between artemether and HP-β-CD was confirmed by Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). The inclusion complex containing artemether: HP-β-CD (1:1 M) was further formulated into tablets by direct compression. The prepared tablets were evaluated for various pharmaceutical characteristics; crushing strength, friability, drug content and in-vitro dissolution profiles. Phase solubility diagram for the complex formation between artemether and HP-β-CD in water at 37 oC indicated the AL type, with an apparent stability constant KC found to be 143 M -1 . FT-IR spectroscopy and DSC confirmed the true inclusion of artemether into the cyclodextrin cavity. Prepared inclusion complex tablets exhibited higher and faster dissolution rate than the pure drug and marketed products. It was observed that the inclusion complex tablet showed a 3.9-fold increase in the amount of drug released in 15 min compared to the plain drug, 1.8-fold increase compared to the marketed brand – Lumartem® and 1.6-fold increase compared to Coartem® . At 120 min, none of the marketed tablets released up to 90 % of the drug, but the inclusion complex tablet achieved 90 % drug release viii in 31 min. The results of stability studies revealed no change in physical appearance and drug content over a reasonable period (ten weeks for short term stability test and 72 h for accelerated stability test), thus indicating that the formulation was stable. The result of the study shows that complexation of artemether by cyclodextrins is a good approach to enhance the solubility and dissolution rate of the drug.




FIND OTHER RELATED TOPICS


Related Project Materials

COMPARISON OF THE EFFECTS OF CIMETIDINE AND METHYLDOPA ON THE PHARMACOKINETICS OF PARACETAMOL IN HUMAN

ABSTRACT

Comparison of the effects of cimetidine and methyldopa were studied in 5 phases: via phase I, ingestion of paracetamol 1g alone,...

Read more
THE PRESS WAR AGAINST POLITICAL INDISCIPLINE IN NIGERIA

Abstract

"Without information there is no accountability, Information is power and the more peopl...

Read more
AN APPRAISAL OF THE LEGAL AND INSTITUTIONAL FRAMEWORK FOR REGULATING THE IMPACTS OF MINING OF MINERALS ON THE ENVIRONMENT IN NIGERIA

ABSTRACT

Mining of solid minerals is one of the world‟s important industries. Nigeria is blessed with about 44 solid minerals spread over...

Read more
ASSESSMENT OF THE LEVEL OF BIOTECHNOLOGY EDUCATION AMONG TERTIARY EDUCATION STUDENTS IN FEDERAL UNIVERSITY OF OTUOKE IN BAYELSA STATE

​​​​​​​BACKGROUND OF THE STUDY

Biotechnology is one of the most important scientific revolutions of the...

Read more
ASSESSMENT OF DIETARY PATTERN AND NUTRITIONAL STATUS OF PEOPLE LIVING WITH HIV/AIDS ATTENDING SOME VOLUNTARY AND COUNSELLING TEST (VCT) UNITS

ABSTRACT

This study assessed the dietary pattern and nutritional status of People Living with HIV/AIDS (PLWHA) attending...

Read more
AN INVESTIGATION OF SUCCESS CRITERIA FOR ENTREPRENEURSHIP BUSINESS IN NIGERIA

BACKGROUND OF THE STUDY

According to the management school, an entrepreneur is a person who organizes o...

Read more
THE ROLE OF EARLY CHILDHOOD EDUCATION IN FOSTERING INDEPENDENCE

ABSTRACT: The role of early childhood education in fostering independence...

Read more
THE INFLUENCE OF CONTRACT DRAWING ON BUILDING PROJECT

ABSTRACT

It has become a regular occurrence nowadays in which we find the project final cost that will overrun the contr...

Read more
IMPACT OF CORPORATE SOCIAL RESPONSIBILITY OF ORGANIZATIONS IN THE MANUFACTURING SECTOR OF NIGERIA

Background to the Study

According to Osemene O.F. (2012), many organizations in Nigeria are established...

Read more
STATISTICAL ANALYSIS OF TRAFFIC CONGESTION

Abstract

The menace of traffic congestion in Nigeria especially in major cities has been a cause of maj...

Read more
Share this page with your friends




whatsapp