EFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Malaria is the 2nd leading cause of death from infectious diseases in Africa, after HIV/AIDS. It is a major public health problem in Nigeria where it accounts for most cases of hospital visits and deaths than any other country in the world. This study evaluated the effects of coadministration of promethazine and Artemether-Lumenfantrine in mice infected with Plasmodium berghei berghei. The mice were grouped into six groups of 6 mice each. Group 2 – 6 were inoculated with Plasmodium berghei berghei groups. Drug administration was carried out orally and for 5 days, 72 hours after parasite inoculation and parasitaemia seen. The mice were sacrificed on the 8th day. Blood samples were collected and organs harvested for haematological and histopathological evaluations. Parameters evaluated include average parasitaemia inhibition, haematological indices, organ-body weight ratio and liver transaminases. The liver, kidney and heart were subjected to histological evaluation. The result showed that promethazine alone had no significant parasitaemia inhibition but the coadministration of promethazine (both 25 mg/kg and 50 mg/kg) and artemether-lumenfantrine gave a marginal reduction but not a significant one compared to Artemether-lumenfantrine alone. Promethazine showed a significant reduction in Haemoglobin, Pack cell volume, RBC, and increase in neutrophils compared to Artemether-Lumenfantrine alone, but no effects compared to the infected control. Its co-administration of promethazine (25 mg/kg) with Artemether-Lumenfantrine gave a marginal reduction, but not a significant difference in Hb, PCV and RBC. The 50mg/kg dose of promethazine co-administered with artemetherlumenfantrine gave lower values of PVC, Hb, RBC than the 25mg/kg promethazine dose plus artemether-lumenfantrine. The liver transaminases were significantly (p≤0.05) increased for Promethazine co-administered with artemether-lumenfantrine compared to Artemtherlumenfantrine alone, although the values of AST, ALT and ALP were still mostly within the normal ranges ( AST-20-298U/l, ALT-17-80U/l, ALP-30-110U/l). Histology sections of the liver showed slight increase in hepatic congestion and lymphocyte hyperplasia, renal sections showed no significant changes while the heart sections showed slight lymphocyte hyperplasia. The study showed that co-administration of Promethazine and Artemether-lumenfantrine possesses no advantage over Artemether-Lumenfantrine alone and it has tendencies of toxicity with continuous use.
Related Project Materials
DESIGN AND IMPLEMENTATION OF ONLINE EXAMINATION SYSTEM FOR STAFF RECRUITMENT
INTRODUCTION/BACKGROUND OF THE STUDY
An online examination system for recruitment of staff is a web app...
THE EFFECT OF FAMILY BACKGROUND ON STUDENTS ACADEMIC PERFORMANCE IN SECONDARY SCHOOL
Abstract
The purpose of the study is to find out the effect of home background on the student’s academic per...
PREVALENCE OF HYPERTENSION IN A PREGNANT WOMAN IN MAIDUGURI
Background of the study
In the language used in the medical field, high blood pressure is referred to a...
INVESTIGATING THE EFFECTS OF EARLY CHILDHOOD EDUCATION ON CREATIVE THINKING SKILLS
ABSTRACT: Investigating the effects of early childhood education on...
YOUTH EMPOWERMENT AS A STRATEGY FOR REDUCING CRIME IN NIGERIA
BACKGROUND OF THE STUDY
Youth empowerment involve build the capacity of young people and motivating them to take respons...
THE ROLE OF DIGITAL BADGES IN RECOGNIZING VOCATIONAL COMPETENCIES
ABSTRACT: This study explores the role of digital badges in recognizing vocational competencies, focusing on their potential to enhance creden...
THE ROLE OF PUBLIC ACCOUNTANTS IN FRAUD PREVENTION AND DETECTION
THE ROLE OF PUBLIC ACCOUNTANTS IN FRAUD PREVENTION AND DETECTION
ABSTRACT
This study examines the role of public accountants in...
CONDITIONS OF SERVICE AND TEACHER’S JOB SATISFACTION IN SECONDARY SCHOOL IN LOCAL EDUCATION COMMITTEE, UYO AKWA IBOM STATE
ABSTRACT
This study investigated the “Conditions Of Service And Teacher’s Job...
PERCEPTION OF MASS MEDIA AS TOOLS FOR SENSITIZING RURAL DWELLERS ABOUT INFECTIOUS EPIDEMIC: A CASE STUDY OF CORONA VIRUS IN NIGERIA
ABSTRACT
This research work empirically explored the perception of mass media as tools for sensiti...
A CONTRASTIVE STUDY OF AFEMAI AND ENGLISH MORPHOLOGICAL STRUCTURES WITH LEARNING AND TEACHING IMPLICATIONS
ABSTRACT
The study aimedat Contrasting Afemai and English Morphological Structures with Learning and Teaching Implications.Morphology is...
