0704-883-0675     |      dataprojectng@gmail.com

DEVELOPMENT OF A FILLER-BINDER DISINTEGRANT FOR DIRECT COMPRESSION TABLETING BY CO-PROCESSING MICROCRYSTALLINE CELLULOSE AND CROSPOVIDONE

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to optimize the composition of the co-processed excipient (CPE). The optimized CPE containing MCC (99 %) and CPV (1 %) was prepared using wet massing technique. Solid-state properties of CPE were characterized in comparison to MCC and CPV using optical and scanning electron microscopy (SEM), Powder XRay Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-red spectroscopy (FT-IR). Powder properties such as flowability, compressibility, moisture sorption capacity, moisture content, dilution potential and lubricant sensitivity ratio (LSR) were also evaluated using standard techniques. Compaction studies were carried out using Heckel and Kawakita equations as well as compressibility-tabletability-compactibility (CTC) profiling. Tablets were formulated by direct compression incorporating metronidazole as the model drug and properties of tablets evaluated. The study revealed an increase in particle size which enhanced the flowability of MCC as a co-processed excipient. Solid state properties of CPE revealed a material consisting of irregular shaped fibrous particles characterized by a rough texture. PXRD and DSC scans presented a material that is semi-crystalline in nature. Moisture content and moisture sorption capacity of MCC was found to decrease as a result of co-processing. The extent of plastic deformation was reduced in MCC when co-processed with CPV and this translated to a reduction in the tabletability of MCC. Tablets formulated with CPE disintegrated at 11.48mins as compared to MCC tablets that disintegrated at 26.88 mins and this was reflected in the in vitro drug release profile with CPE tablets viii attaining maximum drug release at 20mins compared to MCC tablets that attained maximum drug release at 60mins. Thus, the functionality of MCC as a disintegrating filler binder for direct compression tableting was improved by co-processing with crospovidone.





Related Project Materials

AWARENESS AND PRACTICE OF GREEN CONSTRUCTION

ABSTRACT

In spite of the huge environmental and energy problem in Nigeria, designers have not seen the...

Read more
STUDY OF THE NEGATIVE IMPACT OF TECHNOLOGICAL DEVELOPMENT ON THE SECRETARY IN A MODERN OFFICE

BACKGROUND OF THE STUDY
In the public and private sectors of the Nigerian economy, secretaries are usually...

Read more
THE IMPACT OF OUTDOOR ADVENTURE PROGRAMS ON EARLY CHILDHOOD DEVELOPMENT

ABSTRACT: The impact of outdoor adventure programs on early childhood developme...

Read more
THE IMPACT OF STRATEGIC HUMAN RESOURCE MANAGEMENT ON ORGANIZATIONAL PERFORMANCE

ABSTRACT

The subject matter of this study is the impact of strategic Human Resource Management in Organization. The purp...

Read more
THE IMPACT OF AUTOCRATIC LEADERSHIP ON TEAM DYNAMICS

THE IMPACT OF AUTOCRATIC LEADERSHIP ON TEAM DYNAMICS

This study examines the impact of...

Read more
PERCEPTION OF BANK CUSTOMERS ON CBN'S CASHLESS POLICY IN NIGERIA

Abstract

The study was carried out on perception of bank customers on CBN's cashless policy in Nigeria. The Central...

Read more
ASSESSMENT OF CIVIL SOCIETY ORGANIZATION - LEGISLATURE PARTNERSHIP: A CASE STUDY OF THE FIRST AND SECOND SESSIONS OF THE 9TH NATIONAL ASSEMBLY

Background to the Study

Civil Society Organizations (CSOs) are enormously important players in international development...

Read more
FARMERS AND HERDSMEN CLASHES; BOLSTERING AGRICULTURAL DEVELOPMENT THROUGH THE INSTRUMENTALITY OF LAW

Abstract

Land is probably the most important resources needed by man for his day to day existence. All human livelihoods...

Read more
ASSESSMENT OF THE PROBLEMS IN THE MANAGEMENT OF URBAN HOUSING

Abstract

The high rate of migration, coupled with population increase triggered rapid urbanization in t...

Read more
DESIGN AND IMPLEMENTATION OF AN ONLINE MARKETING INFORMATION MANAGEMENT SYSTEM

 

ABSTRACT

 

Online marketing, which is also referred to as internet marketing, invol...

Read more
Share this page with your friends




whatsapp