THE USE OF GELATIN-ACACIA CO-PRECIPITATE (GELAC) IN THE FORMULATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Gums find application in tablet formulation as binder because of their adhesive nature. Natural gums are promising biodegradable polymeric materials. The aim of this study was to prepare a gelatin and acacia co-precipitate (GelAc) to be used as a release retardant in the formulation of sustained release matrix Tablets of diclofenac sodium. Gelatin and acacia solution was precipitated in a ratio of 1:1 using acetone as the precipitating solvent. The dried product was size reduced and the physicochemical properties of the precipitate (GelAc) were evaluated with respect to micromeritics and Fourier Transform Infrared (FT-IR) spectroscopy. FT-IR of GelAc showed no interaction between GelAc and diclofenac. GelAc was used in varying percentages of (10 - 50 %) of the total weight of the Tablet formulation. The formulated tablets were analysed for uniformity of weight tablet thickness and diameter, crushing strength, disintegration time, friability and content uniformity. In-vitro drug release profile of diclofenac sodium from GelAc matrix tablets were also studied using Simulated Gastric Fluid (SGF) for the first two hours and Simulated Intestinal Fluid (SIF) for the next eight hours. Hydroxypropylmethylcellulose (HPMC) was used as a standard matrix to compare the sustaining action of GelAc as a drug retardant for diclofenac sodium. Result from this study showed a good yield of GelAc (92.39 %) from the Coprecipitation. GelAc also had good flow properties. The tablets produced passed the official test for Tablets and had a good content uniformity. Dissolution tests carried out showed that with an increase in GelAc concentration there was a reduction in release rate. GelAc sustained the release of diclofenac sodium for over ten hours. Tablet formulation G2 containing 20 % GelAc was considered the best as it gave the highest release co- efficient value (n) at 0.963.The result from this study shows that GelAc can be used to formulate sustained release tablets of diclofenac sodium.
Related Project Materials
MARITIME ENTREPRENEURSHIP AND ECONOMIC DEVELOPMENT IN NIGERIA
Abstract
The Nigerian experience revealed much confusion for several reasons. Apart from getting involved in the turbule...
PROBLEMS OF MANAGING PUBLIC SECTOR
ABSTRACT
It is a fact that there are some factors that are responsible for the poor performance of publ...
THE ROLE OF ADVERTISING IN MARKETING OF HOTEL SERVICES CALABAR METROPOLIS
Abstract
This study is intended to find out the impact of Advertising on the Marketing of hotel services in Calabar metr...
CORPORATE SOCIAL RESPONSIBILITY REPORTING AND EXECUTIVE COMPENSATION IN NIGERIA
Background to the study
The increased interest in the role of business in society today has been promp...
AN ASSESSMENT OF THE IMPACT OF BASIC HEALTH CARE PROVISION FUND IN IMPROVING FINANCIAL ACCESS TO HEALTH CARE SERVICE OF UNDER FIVE CHILDREN OF NINGI LGA BAUCHI STATE
ABSTRACT
This study was carried out on an assessment of the impact of basic health care provision fund...
THE ROLE OF TRADITIONAL INSTITUTIONS IN CONFLICT RESOLUTION IN NIGERIA A STUDY OF ANAMBRA STATE
Background of Study
The concept of traditional institution‖ has been the major phenomena in the recent...
THE IMPACT OF STAFF WELFARE SCHEME ON WORKERS PRODUCTIVITY: A CASE STUDY OF COLBEN
ABSTRACT
This study examined the place of welfare programme on worker’s productivity in an instit...
AN INVESTIGATION ON THE LEVEL OF PHONOLOGICAL INTERFERENCE IN THE SPEECH OF HAUSA-ENGLISH BILINGUAL
STATEMENT OF THE PROBLEMS
This work is set out to find the level of phonological interference in the speech of Hausa-En...
DEVELOPMENT OF TOTAL QUALITY MANAGEMENT MODEL FOR SMALL AND MEDIUM SCALE CONSTRUCTIION FIRMS IN SOUTH-EAST NIGERIA
Statement of the Problem
Over the years, SMCFs in Nigeria have recorded a low level of participation and have often been sidelined in lar...
ISOLATION AND MOLECULAR CHARACTERIZATION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS FROM POULTRY AND POULTRY FARM WORKERS IN NIGERIA
ABSTRACT
The increasing rate of drug resistance associated with methicillin resistant Staphylococcus aureus is not only a problem in the...
