EVALUATION OF THE BINDING AND SUSPENDING PROPERTIES OF BAGGASE-DERIVED METHYLCELLULOSE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Sourcing of raw materials for use in pharmaceutical industries is a continuing challenge. Excipients, which form the bulk of a dosage form, are derived either from natural sources or synthesized wholly or semi-synthesized. The absence of an ideal excipient material continues to spur research towards identifying and developing excipients from various sources. One of such potential sources is sugar cane bagasse which is an abundant agricultural waste. This work, investigated the properties of derived methylcellulose from sugarcane and evaluated its suitability as a pharmaceutical grade excipient. Methylcellulose was derived from locally sourced bagasse in Zaria, Nigeria by standard extraction procedures. The bagasse-derived methylcellulose (BDMC) was characterised by studying its physicochemical properties, namely moisture content, particle size distribution, shape and viscosity. The stability and flow properties of the powder were also investigated. To confirm the quality of the BDMC, the measured properties were compared with those of a highgrade standard methylcellulose (Methocel® ). To ascertain its suitability as an excipient, its effectiveness as a binder in a large dose formulation was studied using 500 mg paracetamol tablets. Its use as a suspending agent was investigated in co-trimoxazole and metronidazole suspensions. The physical properties such as mean particle size, size distribution, shape, and viscosity of BDMC compared favourably with those of Methocel® . The disintegration time, crushing strength, friability and dissolution profiles of tablets formulated with BDMC as binder were very similar to those prepared with Methocel® . BDMC and Methocel® containing suspensions exhibited pseudoplastic flow behaviour as indicated by their reduced viscosity values. The redispersibility study revealed that, both BDMC and Methocel® influenced the intrinsic vii properties of the active constituents in the suspension formulations. Suspensions made with Methocel® were more flocculated than those formulated with BDMC. Results of the various parameters studied indicated that concentration of 2 per cent of the BDMC can be used as a binder to produce pharmaceutical grade tablets. It is also a suitable suspending agent for producing flocculated, easily dispersible suspensions of indiffusible pharmaceutical active ingredients such as co-trimoxazole and metronidazole.
Related Project Materials
THE INFLUENCE OF BUSINESS ANALYTICS ON ORGANIZATIONAL LEARNING
Abstract: THE INFLUENCE OF BUSINESS ANALYTICS ON ORGANIZATIONAL LEARNING
This study investigates...
PAIN MANAGEMENT OF CANCER PATIENTS IN UNIVERSITY TEACHING HOSPITALS IN NIGERIA
ABSTRACT
The number of cancer patients in the world is increasing. Of the estimated nine million new cases every year, more than half are...
INFLUENCE OF EMPLOYMENT ON WIVES ROLE PEREORMANCE AMONG FEDERAL CIVIL SERVANTS IN ZARIA METROPOLIS, NIGERIA
ABSTRACT
This study examined the influence of employment on the wives role performance among Federal Civil Servants in Zaria metropolis....
APPLICATION OF GRAVITY DATA IN DETERMINATION OF THE CRUSTAL THICKNESS AND STABILITY OF PARTS OF SOUTHERNNIGERIA
ABSTRACT
This study focuses on the application of gravity data in determination of the distance between the earth surface and moho (crust...
PRODUCTION OF CUSTARD FROM CORN STARCH
ABSTRACT
Custard is a fine textured food product made from edible corn starch and other concentrated nutrients or the co...
TACKLING INSURGENCY USING CRYPTOGRAPHY
STATEMENT OF THE PROBLEM
Insurgency has really caused destruction, poverty and many individuals have lost their life dur...
AN ASSESSEMENT OF THE LEGAL STRUCTURE FOR THE PROTECTION OF WOMEN’S RIGHTS IN NIGERIA
BACKGROUND OF STUDY
Because of their status as human beings, both men and women are entitled to have all of their...
AN INVESTIGATION OF THE SCHOOL FACTORS CONTRIBUTING TO POOR TEACHING AND LEARNING OF CHEMISTRY IN SECONDARY SCHOOL
Background of the Study
The physical world is a collection of "mysteries" to the layman. Howe...
THE UNITED NATIONS SECURITY COUNCIL AND INTERNATIONAL CONFLICT RESOLUTION: A CASE STUDY OF THE UN SECURITY COUNCIL WEAPON INSPECTION IN IRAQ.
EXCERPT FROM THE STUDY
The United Nations Security Council (UNSC) is the organ of the United Nations charged with mainta...
COMPETENCY IMPROVEMENT NEEDS OF TECHNOLOGY TEACHERS IN THE IMPLEMENTATION OF BASIC TECHNOLOGY
EXCERPT FROM THE STUDY
Effective teaching of introductory/ basic technology require competencies. Competencies based on...
