EFFECTS OF VITAMIN B COMPLEX THERAPY ON TEMPORAL VARIATION IN GENTAMICIN NEPHROTOXICITY IN WISTAR RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The efficacy and toxicity of several drugs is circadian-rhythm dependent, and this can be exploited as a guide to ameliorate such drug toxicity. Gentamicin is an aminoglycoside antibiotic used in treatment of a variety of infections. Its use is however limited by its associated nephrotoxicity. This nephrotoxicity is ameliorated by reduction in dosing frequency to once a day dosing, use of antioxidants and exploration of circadian variation in gentamicin nephrotoxicity. Temporal variation in gentamicin nephrotoxicity and the use of antioxidants at the time of highest nephrotoxicity are alternative ameliorative strategies for this established toxicity. This study compares the effect of concurrent administration of vitamin B complex and gentamicin based on its temporal variation in nephrotoxicity, with alternative approaches of use of a single strategy alone. Young wistar rats of both sexes were used in this study. A nephrotoxic dose of gentamicin was determined from a ten day study with 80, 100 and 120 mg/kg intraperitoneal gentamicin administration using selected biomarkers as indices. Nephrotoxicity was accessed by elevation of serum urea and serum creatinine which are biomarkers of nephrotoxicity and histological changes of the kidney. Administration of 100 mg/kg of gentamicin at 0800, 1200, 2000 and 0000 hours resulted in nephrotoxicity with maximal toxicity observed at 1200 hours where the level of serum urea and creatinine differed significantly (p≤0.05) from the normal saline control and minimal toxicity was seen at the 0000 hour. Histology of the kidneys showed lymphocyte hyperplasia, interstitial haemorrhages, tubular and glomerular necrosis in the 1200 hour group which was observed to be mild in the 0000 hour group. No significant change was seen in the levels of serum electrolytes (Na+ , K+ , Cl+ , Ca2+) and liver function enzymes (ALT, AST and ALP) irrespective of time of treatment. Concurrent administration of vi gentamicin and vitamin B complex at 1200 and 0000 hours resulted in amelioration of gentamicin nephrotoxicity. However, the amelioration produced by the administration of gentamicin alone at the time of minimal toxicity (0000 hour) was greater than that produced by concurrent administration of gentamicin and vitamin B complex at this time point. The administration of gentamicin based on its temporal variation in nephrotoxicity offers better amelioration of nephrotoxicity than concurrent administration of gentamicin at the time of highest toxicity with vitamin B complex in wistar rats.
Related Project Materials
AN ASSESSMENT ON THE EFFECT OF HOME DELIVERY AMONG PREGNANT WOMEN
ABSTRACT
The study was designed to determine the effect of home delivery among pregnan...
A CRITICAL REVIEW OF TEACHERS’ QUALIFICATION AND SCHOOL ENVIRONMENT; ITS IMPACT ON JUNIOR STUDENT PERFORMANCE IN BASIC SCIENCE
Statement of the Problem
There are contemporary problems in the teaching and learning of Integrated Sci...
PROLIFERATION OF UNREGISTERED ESTATE AGENT IN REAL ESTATE MARKET
Abstract
This research project is meant to identify the impact proliferation of unregistered estate in abuja Municipalit...
GOVERNMENTS OWNERSHIP AND ITS IMPACT ON MEDIA OBJECTIVITY
Background Of The Study
The mass media are particularly significant tools of communication since they a...
GOVERNMENTAL AND ORGANISATIONAL FACTORS AS PREDICTORS OF OCCUPATIONAL HEALTH AND SAFETY OF FEMALE WORKERS IN INDUSTRIES IN LAGOS STATE, NIGERIA
ABSTRACT viii The protection of workers generally against health and safety hazards at work environments has been emphasised adequately in Internat...
ASSESSMENT OF MARITIME SECURITY, INFORMATION AND COMMUNICATIONS TECHNOLOGY APPLICATION
BACKGROUND OF STUDY
Worldwide Port and Maritime operations and their associated facilities and infrastr...
POLITICAL LEADERSHIP AND ECONOMIC DEVELOPMENT IN DEVELOPING COUNTRIES
ABSTRACT
At independence, the economies of Nigeria and India were dominated by primary production, main...
IMPACT OF CASHLESS POLICY ON PROFITABILITY OF COMMERCIAL BANKS IN NIGERIA
Abstract
This research work examines the impact of cashless policy on the profitability of commercial b...
E LEARNING AND ECONOMICS EDUCATION IN NIGERIA. A CASE STUDY OF OSUN STATE COLLEGE OF EDUCATION ILA ORANGUN
CHAPTER ONE
INTRODUCTION
Background of the study
Electronic l...
A COMPARATIVE SURVEY OF THE ACADEMIC PERFORMANCE OF SCHOOL CHILDREN IN PUBLIC AND PRIVATE PRIMARY SCHOOLS IN NIGERIA
Background to the
