COMPARATIVE IN-VITRO BIOEQUIVALENCE STUDIES OF SOME BRANDS OF METRONIDAZOLE TABLET MARKETED IN ZARIA, KADUNA STATE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Metronidazole is an antibacterial and antiprotozoal drug used in the treatment of amebiasis, giardiasis, trichomoniasis and other microbial diseases. It is an essential drug commonly found in Nigerian market and has so many generics and dosage forms under various trade names by different manufacturers. The purpose of the study was to evaluate and compare the in-vitro bioequivalence of branded and generic metronidazole tablet in three different physiological media (pH 1.2, 4.5 and 6.8). Six brands of metronidazole tablet were randomly selected from different areas of Zaria town and evaluated for quality via identification test, assay, weight variation test, disintegration time test, friability, crushing strength and dissolution. Three UV spectrophotometric methods were developed, validated and used for determining the amount of metronidazole release during the in-vitro dissolution studies. The percentage of metronidazole released was then subjected to in-vitro bioequivalence comparison using the model independent method of comparism. The results showed that all brands passed identification an assay test except brand MD and ME that failed the assay test. The tested brands passed weight variation test, disintegration time test, friability and hardness except brand ME which failed the hardness test. Wavelength of maximum absorbance (ĘŽmax) of 295nm, 345nm and 350nm were recorded for metronidazole in pH media 1.2, 4.5 and 6.8 respectively, with a linear relation at concentration range of 2-64𝜇g/mL. The correlation coefficients were close to unity with percentage recoveries ranging from 98-102% and precision (% CV) 50; therefore, can be used interchangeable with brand MA in all the three simulated physiological media. Also, brand MF had similar dissolution profile with MA in two physiological media (pH 1.2 and 4.5) but not in pH 6.8. However, the dissolution viii profile of brand MD and brand ME were not similar with brand MA in all the three media. The percentage dissolution efficiency (DE) of all the brands in all the three media were within the acceptable limit of ±10%. It was concluded that the branded MA could be interchanged with brand MB and brand MC in all the three media and with brand MF in pH 1.2 and pH 4.5 but not in pH 6.8 and also not with brand MD and brand ME in all the three media.
Related Project Materials
A SURVEY OF TEACHERS’ AWARENESS AND USE OF ASSISTIVE TECHNOLOGY IN TEACHING CHILDREN WITH SPECIAL NEEDS IN NORTH CENTRAL NIGERIA
Abstract
The purpose of the study was to find out teachers’ awareness and use of assistive technology in teaching children with spe...
THE ROLE OF CO-OPERATIVE SOCIETIES TOWARDS DEVELOPMENT OF RURAL AREAS
ABSTRACT
This research work was designed to see to the way the areas could be develope...
CONFLICT MANAGEMENT FOR EFFECTIVE PERFORMANCE IN AN ORGANIZATION (A Case Study Of Union Bank of Nigeria)
ABSTRACT
Managing conflict is a tool for promoting peaceful co-existence between workers and employers in an org...
DEVELOPMENT OF CONCEPTUAL MODELS FOR PLANTS AND EQUIPMENT PROCUREMENT IN TERTIARY INSTITUTIONS
ABSTRACT
This research sole aim is to improve on the development of conceptual procurement models that can create direct and indirect imp...
BUSINESS EDUCATION STUDENTS’ AWARENESS AND UTILIZATION OF E-LEARNING
ABSTRACT
The study investigated the awareness of e-learning and its utilization by business education s...
EFFECTS OF ORGANIZATION STRUCTURE ON EMPLOYEES PERFORMANCE
ABSTRACT
This research work focuses on effects of organization structure on employees’ performanc...
THE IMPACT OF ADVERTISEMENT REVENUE ON MEDIA SUSTAINABILITY (A CASE STUDY OF VANGUARD NEWSPAPER)
CHAPTER ONE
INTRODUCTION
1.1
Abstract The purpose of the study was to find out the basic personal hygiene knowledge and practices among primary s...
ABSTRACT This research examined the Impact of Motivation on Performance of Civil Service in Nigeria wit...
​​​​​​​BACKGROUND OF THE STUDY Account receivable is a broad notion in the banking or financial...
PRACTICE OF PERSONEL HYGIENE KNOWLEDGE AMONG PRIMARY SCHOOL CHILDREN
THE IMPACT OF MOTIVATION ON THE PERFORMANCE OF CIVIL SERVICE IN NIGERIA
ANALYTICAL DESIGN AND IMPLEMENTATION OF A COMPUTERIZED ACCOUNTS RECEIVABLE SYSTEM
