BIOFILM PRODUCTION AND ANTIBIOTIC SUSCEPTIBILITY OF UROPATHOGENS ISOLATED FROM UNIVERSITY TEACHING HOSPITAL IN NIGERIA
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Biofilm Production on surfaces (animate and inanimate object) by microorganisms has become a major concern now in medical settings since it poses threat of induction and spread of resistance among pathogens. Uropathogens as associated with catheterization, ureter and bladder surfaces is of a major interest as far as biofilm production is concerned. This study determined the biofilm production and antibiotic susceptibility pattern of uropathogens isolated from Ahmadu Bello University Teaching Hospital, Zaria. Isolates from urine samples submitted to the Medical Microbiology Laboratory of the hospital were collected over a period of five months and identified using standard microbiological techniques. Alongside, a three months retrospective study within the period of the sample collections was carried out to give a prevalent rate of the occurrence of urinary tract infections in the study area. Further more, the isolates were evaluated for their biofilm production potentials and their susceptibility to antibiotics were determined. The Cefoxitin Disc Test for MRSA and the D-test for erythromycin resistant S. aureus were also carried out. From the retrospective study, Klebsiella spp were the most common bacteria isolated (36.40%), followed by E. coli (34.98%), S. aureus (7.77%), Proteus spp (2.47%), Pseudomonas spp (1.77%) and others including: Enterococcus spp, Citrobacter spp, Entrobacter spp, Alkaligines spp, Providencia spp, Streptococcus spp, Acenobacter spp and Candida spp. An overall prevalence of 19.71% of the uropathogens was obtained from the retrospective study. Klebsiella spp: 55 (37.93%), E.coli: 35 (24.14%), Proteus spp: 12 (8.28%), P. earuginosa: 20 (13.79%) and S. aureus: 23 (15.86%), were identified as uropathogens from the urine isolates. The result showed high percentage of biofilm production by all the five species of the uropathogens with xx Proteus spp (100%) being the highest, followed by P. aeruginosa (90%), S. aureus (82.61%), E. coli (71.43%) and Klesiella spp (63.64%). Antibiotic susceptibility testing recorded that, amikacin (87.97%), meropenem (84.04%), p-tazobactam (83.11%) and tigecycline (81.75%) were the most effective against the uropathogens whereas, amoxicillin (26.79%), cotrimoxazole (36.75%), tetracycline (38.12%), ceftazidime (38.97%), ceftriaxone (52.615%), clindamycin (21.74%), and cefoxitin (47.83%) were generally less effective. There was no significant difference between the percentage of the multidrug resistant isolates of the biofilm producers and the non biofilm producers using chi square at < 0.05 significance level. Ciprofloxacin was less effective against P. aeruginosa (75.00% were resistant) compared to other uropathogens. Among the S. aureus isolates, 56.52% were MRSA, 21.74% were erythromycin resistant and these were constitutive not inducible clindamycin resistance. The molecular work identified one of the Klesiella spp (K10) to harbor qnrS gene, indicating the presence of this mobile genetic element in the study area.
Related Project Materials
THE ROLE OF FIDUCIARY ACCOUNTANTS IN LITIGATION SUPPORT
THE ROLE OF FIDUCIARY ACCOUNTANTS IN LITIGATION SUPPORT
Abstract: Fiduciary accountants play a crucial role in litigation support, provid...
AN ANALYSIS OF DOMESTIC IMPLEMENTATION OF THE KYOTO PROTOCOL ON CLIMATE CHANGE IN NIGERIA
ABSTRACT
The global nature of climate has become very well appreciated in the developing as well as developed world. For example, in its...
FACTORS ASSOCIATED WITH MASS FAILURE OF STUDENT IN ENGLISH LANGUAGE IN SECONDARY SCHOOLS (CASE STUDY OF NSUKKA LGA)
ABSTRACT
This study was on the factors associated with mass failure of students in the
ABSTRACT Effective contract planning in construction projects is not only crucial to attainment ofproject objectives but...
ABSTRACT Over the years, Nigeria was experienced series of attacks, agitations, restiveness and blests ranging from diverse regions and l...
ABSTRACT The study was designed to determine the effect of home delivery among pregnan...
ABSTRACT This research work was conducted to investigate the impact of the oil industry on the economic growth performance of Nigeria. In...
ABSTRACT The level of some trace elements including cadmium, cobalt, copper and iron in water and vegetable samples of cabbage (Brassica...
EXCERPT FROM THE STUDY Contemporary banks increasingly realize that customer orientation is a very important factor for their success in...
THE IMPACT OF TECHNOLOGY ON GOVERNMENTAL ACCOUNTING PRACTICES Abstract This research examines the impact of technology on gover...
THE IMPACT OF EFFECTIVE CONTRACT PLANNING ON CONTRACTORS PROFIT (A CASE STUDY OF JULIUS BERGER NIGERIA PLC, UYO)
POVERTY AND YOUTH RESTIVENESS IN NIGERIA AN EVALUATION OF THE BOKO HARAM CRISIS
AN ASSESSMENT ON THE EFFECT OF HOME DELIVERY AMONG PREGNANT WOMEN
THE IMPACT OF OIL REVENUE ON THE ECONOMIC GROWTH IN NIGERIA (1980-2010)
DETERMINATION OF Cd, Co, Cu, AND Fe IN WATER AND SOME VEGETABLE CROPS CULTIVATED AROUND GALMA AND KUBANNI RIVERS, ZARIA
CUSTOMER ORIENTATION IN BANKING INDUSTRY
THE IMPACT OF TECHNOLOGY ON GOVERNMENTAL ACCOUNTING PRACTICES
