ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Anti-hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root bark on poloxamer 407 induced hyperlipidemic and normal rats was investigated. Phytochemical screening of the extracts revealed the presence of flavonoids, saponins, cardiac glycosides, alkaloids and tannins in the leaves, stem bark and root bark. The average total polyphenol contents of the leaves ethanol (36.11±3.13mg/g gallic acid) and methanol (35.75±1.72mg/g gallic acid) extracts were significantly (p0.05) change between normal control rats and normal treated rats in lipid profile parameters and atherogenic indices. The level viii of liver marker enzymes (ALT, ALP, AST) and liver function parameter (TB, IB) were significantly (p<0.05)higher, and lower (TB, DB) in hyperlipidemic control groups compared to all other groups. The invivo antioxidant activity shows a significantly (p<0.05) higher level of TBARS and a significant (p<0.05) lower level of SOD and CAT in hyperlipidemic groups when compared to all treated groups. In both liver and kidney, the leaves and stem bark extract significantly (p<0.05) lowers levels of TBARS of normal control rats compared to normal treated and all induced treated groups. All the extractsactivity in the liver and leaves extract in the kidney of normal rats show a significant higher level of CAT compared with other treated groups. The study shows that vitexdonianapossesses anti-hyperlipidemic potential.
Related Project Materials
TEACHING RESOURCES AND TEACHING EFFECTIVENESS IN PUBLIC SECONDARY SCHOOLS
ABSTRACT
This study investigated the influence of teaching materials on teaching effectiveness in secondary schools in M...
DESIGN AND IMPLEMENTATION OF A COMPUTER SOFTWARE FOR THE SOLUTION OF LINEAR EQUATION
OBJECTIVES OF THE STUDY
The main concern of this project work is to study the methods and processes for...
IMPACT OF INVENTORY VALUATION METHODS ON THE PROFITABILITY OF CHAMPIONS BREWERIES
Abstract
The research work titled “impact of inventory valuation methods on the profitability of Champion Brewerie...
THE IMPACT OF CASHLESS POLICY ON ECONOMIC GROWTH OF NIGERIA
Background Of The Study
The introduction of electronic banking, online transactions and mobile banking...
EFFECTS OF CHILD ABUSE ON THE ACADEMIC ACHIEVEMENTS OF STUDENTS OF SELECTED SECONDARY SCHOOLS
Background of the Study
The joy of giving birth to children and helping them flourish to the point where they may reali...
AN ASSESSMENT OF PUBLIC SECTOR AUDITING AND ACCOUNTABILITY MECHANISMS
AN ASSESSMENT OF PUBLIC SECTOR AUDITING AND ACCOUNTABILITY MECHANISMS
This study examines public sector auditing and acc...
LIQUIDITY MANAGEMENT IN BANKS: A STUDY OF SELECTED COMMERCIAL BANKS IN NIGERIA (2000-2009)
ABSTRACT
This study sought to examine the challenges of Liquidity Management in Nigeria’s...
THE EFFECTS OF EARLY MARRIAGE ON THE SOCIO-ECONOMIC AND EDUCATION DEVELOPMENT OF A CHILD IN EDUCATIONAL DISTRICT
ABSTRACT
This study was conducted to appraise the effect of early marriage on child education and socio...
ASSESSMENT OR CONTROLLING OF DAMPNESS IN EXISTING BUILDING IN NIGERIA
ABSTRACT
This study investigated the assessment for controlling of dampness in an existing building in Nigeria. The stud...
THE SAVINGS MOBILIZATION FOR ECONOMIC DEVELOPMENT IN NIGERIA BANKING INDUSTRY (1990 – 2004) (A CASE STUDY OF UNION BANK OF NIGERIA PLC)
ABSTRACT
The research was based on the topic “mobilizing Domestics savings for economic growth and development in...
