APHRODISIAC AND REPRODUCTIVE STUDIES ON METHANOL ROOT BARK EXTRACT OF SECURINEGA VIROSA (ROXB. EX. WILLD.) BAILL IN MALE WISTAR RATS
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- NGN 3000
ABSTRACT
Securinega virosa (SV) is a widely used plant in traditional medicine. The root is used as an aphrodisiac in north western Nigeria. The aim of the study was to provide pharmacological rationale for the ethnomedical use of the root of Securinega virosa as aphrodisiac as well as to establish its general male reproductive effects. A total of twenty four male wistar rats were randomly divided into four groups of six animals each (n=6), and used to assess the aphrodisiac potential of the extract which includes; mounting, intromission, ejaculation frequencies and latencies. Female Wistar rats used for pairing were brought to estrus phase of their reproductive cycle using oral suspension of ethinyl oestradiol (100 μ/ml/ animal), 48 hours prior to the pairing plus progesterone at a dose of I mg/animal injected subcutaneously, 6 hour prior to the experiment. For the assessment of male reproductive functions, a total of sixty (60) male Wistar rats were randomly divided into four groups (A, B, C, D) each consisting of fifteen (n=15) rats. Groups B, C and D were administered with the extract of Securinega virosa once daily at 24 hours interval at different graded doses of (31.25 mg/kg, 62.5mg/kg, and 125 mg/kg) respectively for 21 days. The rats in group A served as control and received 1ml/kg of distilled water for the same number of days. The extract significantly (P< 0.05) improved mating behavior, increased intromission frequency (IF) at 125 mg/kg, and significantly decreased (P< 0.05) ejaculatory latency (EL) at 31.20 mg/kg. Serum testosterone (ng/ml) level was significantly increased (P< 0.05) following first week of administration at doses of SV 62.50 mg/kg and 125 mg/kg; and also at third week of administration at dosage of SV 62.50 mg/kg. Serum LH (ng/ml) also increased at dose of 62.50 mg/kg following both first and the third week, while serum FSH (ng/ml) increased at 62.50mg/kg after the third week of administration. The extract caused a significant increase (p<0.05) in sperm motility, sperm count, sperm morphology and viability. There was a significant (p< 0.05) decrease in body weight at all the doses tested. The extract caused a significant increase (p< 0.05) in the weight of testes, epididymis and vas deferens weight (g). Histology of the rats treated with the highest dose showed normal seminiferous tubules with a markedly increased concentration of mature spermatozoa relative to the control. It is concluded that the methanol root bark extract of Securinega virosa possesses aphrodisiac activity with concurrent beneficial effects on sperm parameters.
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