0704-883-0675     |      dataprojectng@gmail.com

AN EVALUATION OF THE APHRODISIAC AND FERTILITY ENHANCING EFFECT OF THE METHANOLIC ROOT EXTRACT OF CISSUS POPULNEA Guill.And Perr. (Vitaceae)

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

Aphrodisiac activity of Cissus populnea was assessed using physical, biochemical and psychological methods. Rats were randomized into five groups of six rats. The first group received normal saline (10ml/kg), the second, third and fourth groups received extract doses of 250mg/kg, 500mg/kg and 1000mg/kg respectively while the fifth group received 5mg/kg of sildenafil citrate orally for 28 days. On the 24th day, the effect of the root extract of Cissus populnea (CPRE) on mounting and mating frequencies was evaluated. The psychological (mood) effect of CPRE was evaluated on the 27th day by exposing the treated rats to the elevated plus maze (EPM) for five (5) minutes and the time spent in the open and close arms of the EPM were recorded. On the 29 th day, the rats were anaesthetized with diethylether and blood samples were collected by cardiac puncture for biochemical analysis (testosterone, cortisol, prostate specific antigen (PSA) levels, liver and kidney function parameters). Testes were removed and an incision was made at the caudal epididymis were transferred into a petri dish containing normal saline from where sperm samples were collected using a Neubauler ruled chamber to ascertain the sperm count and morphology. The antioxidant effect of CPRE was compared with that of ascorbic acid using DPPH (2, 2- diphenyl-2- picrylhydrazyl) assay method and was measured at 518nm and the percentage antioxidant activity (AA %) was then calculated. The acute toxicity study revealed that CPRE was relatively safe. The LD50 value was found to be above 5000mg/kg. The phytochemical screening revealed the presence of saponins, flavonoids, terpernoids and tannins. CPRE and sildenafil citrate significantly increased mounting frequency (P≤0.05) and mating frequency (P≤0.05) respectively compared to the negative control; maximum effect was observed at the dose of 500mg/kg of the extract. There was significant (P≤0.01) and dose-dependent decrease in sperm count in the extract treated rats. The motility and percentage of abnormal sperm cells also decreased in the extract treated viii rats compared to the negative control and standard drug sildenafil citrate. The extract produced significant (P≤0.001) and dose dependent increasein testosterone level compared to the control. Significant increase (P≤0.05) in cortisol level was observed in the sildenafil and extract (250 and 500mg/kg) treated rats compared to the control. There was no significant change in prostate specific antigen level in the CPRE however sildenafil citrate treated rats showed significant ((P 0.05) increase in PSA level compared to the control group. The administration of the extract did not show any increase in the level of hepatic andnephrotic enzymes. However there was significant increase in AST level in the extract and sildenafil treated rates compared to the control group. The percentage antioxidant activity of ascorbic acid was significantly (P≤0.05) higher than that of the extract. The extract and sildenafil significantly (P≤0.01) increased the time spent in the open arm while significantly (P≤0.01) decreasing the time spent in the closed arm in the EPM compared to the control group. The methanolic root extract of Cissus populneais relatively safe. The aphrodisiac property may be attributed to a combination of increased in testosterone level, phytochemicals such as saponins and flavonoids and its potential to relieve stress and anxiety. The extract does not have fertility enhancing effect as shown by the decrease in sperm count, motility and increase in percentage of abnormal sperm cell.




FIND OTHER RELATED TOPICS


Related Project Materials

ANALYSIS OF SAVINGS AND INVESTMENT STRATEGIES AMONG CASSAVA PROCESSORS

ABSTRACT

The need to have adequate record about savings and investment necessitated this study. The spe...

Read more
THE ROLE OF A TEACHER IN EDUCATIONAL PLANNING

​​​​​​​BACKGROUND OF THE STUDY

Education is recognized as the key to a nation's growth on a global...

Read more
ASSESSMENT OF AVAILABILITY AND UTILIZATION OF ELECTRONIC MEDIA RESOURCES IN TEACHING ENGLISH LANGUAGE IN SENIOR SECONDARY SCHOOLS IN NIGERIA

Background to the Study

Electronics media are considered as important instrument in modern world in facilitating quality...

Read more
IMPORTANCE OF HUMAN RESOURCES MANAGEMENT IN PROMOTING EMPLOYEES PERFORMANCE

ABSTRACT

The study was focused on the importance of human resources management in employee performance...

Read more
COMPARATIVE ANALYSIS OF VIEWERSHIP PREFERENCE OF FOREIGN AND LOCAL TELEVISION STATIONS AMONG NIGERIAN YOUTHS

Abstract

The research analyzed viewership preferences of foreign and local television station among Nigeria...

Read more
AN ASSESSMENT OF EMPLOYEE PERFORMANCE AND GRIEVANCE HANDLING PROCEDURES (A CASE STUDY OF JAYEE UNIVERSITY COLLEGE)

BACKGROUND OF THE STUDY

Human resources, non-human resources, and time are the three most important thi...

Read more
A Discourse on Accumulation and the Contradictions of Capitalist Development in Nigeria

ABSTRACT

The study examines and conceptualizes accumulation in the context of Nigeria‟s neocolonial state. It investigates the nature of...

Read more
THE SIGNIFICANCE OF PRODUCT QUALITY ON THE DEMAND FOR INDUSTRIAL PRODUCTS (A CASE STUDY OF SETRACO NIGERIA PLC)

Abstract

This project title the Significance of product Quality on the Demand Industrial Product was carried out with Se...

Read more
THE ROLE OF AUDITORS AND THE METHOD OF INTERNAL CONTROL IN LOCAL GOVERNMENTS

ABSTRACT

The subject of this research investigation is “The Role of Internal Auditor and the method of Internal Co...

Read more
THE BENEFITS OF EARLY CHILDHOOD EDUCATION IN REDUCING FOOD INSECURITY

 ABSTRACT: The benefits of early childhood education in reducing food...

Read more
Share this page with your friends




whatsapp