DYNAMIC MODEL DEVELOPMENT AND RECEDING HORIZON CONTROL OF BLOOD GLUCOSE CONCENTRATION
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Biological systems usually consist of large number of components and involve processes at a variety of spatial, temporal and biological scales. This study presents a framework for model identification and the use of Global Sensitivity Analysis (GSA) in systems biology modelling and shows how the information content of clinical data from Short Insulin Tolerance Test (SITT) can be handled by optimal model-based estimation techniques. The goal is to identify dynamic model of type II diabetes and estimate a set of parameters of the model with greater accuracy and precision. Based on the SITT data, the blood glucose dynamic model was identified as a system of linear differential equation with constant coefficients (parameters). The sensitivity of the parameters was tested using a novel GSA based approach, and Derivative-Based Global Sensitivity Measures (DGSM). The proposed approach was implemented in SensSB (a Matlab based toolbox). For the purpose of comparison, the sensitivity of the model was also tested using Sobol’s method and a local approach. The results have shown that the model is less sensitive to the third parameter ( ) and the model fits the SITT data satisfactorily. Subsequently, a control strategy called receding horizon control was investigated to regulate blood glucose concentration under the model predictive control framework. Two forms of receding horizon control strategy (fixedend and moving-end) were proposed and applied to the dynamic model to maintain blood glucose concentration. Different disturbance scenarios were generated to evaluate the performance of the two strategies in terms of its efficiency to handle disturbances. The control strategies successfully addressed the issues of the input/external disturbance considered for the patients in a virtual situations which maintain blood glucose level at 80.06 mg/dL.
Related Project Materials
THE FARMEWORK OF ECONOMIC AND HUMAN RIGHTS UNDER THE ECOWAS TREATY: A CASE STUDY OF IMPLEMENTATION IN NIGERIA
ABSTRACT
The 1975 ECOWAS Treaty made by the founding fathers of the West African Regional Integration Philosophy was revised in 1993 in v...
AVAILABILITY OF LABORATORY FACILITIES FOR EFFECTIVE TEACHING-LEARNING OF MATHEMATICS, INTEGRATED SCIENCE AND COMPUTER SCIENCE IN JUNIOR SECONDARY SCHOOLS IN ENUGU NORTH L.G.A
ABSTRACT
The primary objective of this research work was to determine the availability of laboratory fa...
LEASING AS A SOURCE OF FUND FOR CORPORATE ENTITIES
ABSTRACT
Many companies are now accepting and engaging in the leasing business as an alternate source of funds. This res...
ROLE OF ENUGU STATE BROADCASTING SERVICE IN CONFLICT RESOLUTION (A STUDY OF ENUGU NORTH)
Abstract
The aim of this study was to analyze the Role of Enugu State Broadcasting Service in Conflict Resolution. (A study of Enugu Nort...
THE IMPACT OF DOCTRINAL DIFFERENCE ON THE CHURCH
ABSTRACT
This study was to examine theinfluences of doctrinal differences among churches in Nigeria, wh...
AN ASSESSMENT OF THE INFLUENCE OF OVERPOPULATED CLASS ROOM IN SECONDARY SCHOOLS IN LAGOS STATE
BACKGROUND OF THE STUDY
Since the ingrained firmness of western education in Nigeria, It has...
INFLUENCE OF SOCIO ECONOMIC BACKGROUND ON SECONDARY SCHOOL STUDENT PERCEPTION OF THEIR SCHOOL LEARNING ENVIRONMENT IN CALABAR MUNICIPALITY, CROSS RIVER STATE
Background to the study
Socio-economic background or status refers to a person’s position in a given group, societ...
RISK MANAGEMENT MEANS OF MINIMIZING ACCIDENT IN THE AVIATION INDUSTRY IN NIGERIA
Abstract
Our risk exposures are influenced by our economy, lifestyles, psychical well being, occupation, environment et...
THE TRENDS IN STUDENTS’ PERFORMANCE IN JUNIOR CERTIFICATE EXAMINATION IN ENGLISH LANGUAGE AND BASIC SCIENCE
ABSTRACT
The trend of students’ performance can positively change through a gradual process of using an up...
PHARMACOGNOSTIC AND SOME BIOLOGICAL STUDIES ON MAYTENUS SENEGALENSIS (LAM.) EXELL (CELASTRACEAE)
ABSTRACT
Maytenus senegalensis (Celastraceae) is commonly known as thorny staff tree or confettii tree, is of high traditional use among...
