ABSTRACT
There is increasing recognition of the importance of early environmental exposures in the development of childhood asthma. Outdoor air pollution is a recognized asthma trigger, but it is unclear whether exposure influences incident disease. We investigated the effect of exposure to ambient air pollution in utero and during the first year of life on risk of subsequent asthma diagnosis in a population-based nested case-control study. The study assessed all children born in southwestern British Columbia in 1999 and 2000 (n = 37,401) for incidence of asthma diagnosis up to 34 years of age using outpatient and hospitalization records. Asthma cases were age- and sex-matched to five randomly chosen controls from the eligible cohort. We estimated each individual’s exposure to ambient air pollution for the gestational period and first year of life using high-resolution pollution surfaces derived from regulatory monitoring data as well as land use regression models adjusted for temporal variation. We used logistic regression analyses to estimate effects of carbon monoxide, nitric oxide, nitrogen dioxide, particulate matter. A total of 3,482 children (9%) were classified as asthma cases. We observed a statistically significantly increased risk of asthma diagnosis with increased early life exposure to CO, NO, NO2, PM10, SO2, and black carbon and proximity to point sources. Traffic-related pollutants were associated with the highest risks: adjusted odds ratio = 1.08 (95% confidence interval, 1.041.12) for a 10-microg/m3 increase of NO, 1.12 (1.071.17) for a 10-microg/m3 increase in NO2, and 1.10 (1.061.13) for a 100-microg/m3 increase in CO. These data support the hypothesis that early childhood exposure to air pollutants plays a role in development of asthma.
Abstract
This project points out the important and necessity of good human relations aimed at improving secretarial fun...
Background of the Study
National nursing licensure examinations serve as a benchmark for assessing the competency of nursing graduates an...
ABSTRACT
This study examined building maintenance in Nigeria: structural deterioration, investigation o...
ABSTRACT
The study was carried out to investigate student‘s perception of the determinants of enrolment in agricultural education p...
Abstract
The purpose of this study is to look into the factors, which uninfluenced first year student’s academic p...
BACKGROUND OF THE STUDY
The problems the average teenage or youth in secondary schools in Nigeria has r...
BACKGROUND OF THE STUDY
Education is, without a doubt, the most important instrument for a society'...
Background of the Study
Parental perceptions play a crucial role in shaping the success of early childhoo...
Background of the Study:
In recent years, school‐community partnerships have emerged as a pivotal element in transforming e...
Background of the Study
Credit risk management is a pivotal aspect of banking, and in Islamic finance, it assumes distinct...