CHRONIC TOXICITY EXTRACTION OF AFRICAN MESQUITE TREE PART EXTRACT IN RAT
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: Available
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
This study investigated the chronic toxicity of African Mesquite tree (Prosopis africana) extracts in Wistar rats, focusing on biochemical, hematological, and histopathological effects. The extracts were administered at doses of 100 mg/kg, 300 mg/kg, and 600 mg/kg over a 90-day period. Biochemical analyses indicated significant dose-dependent increases in liver function markers (ALT, AST, ALP, and bilirubin) and kidney function markers (urea and creatinine), suggesting hepatocellular injury and nephrotoxicity. Hematological findings showed reductions in hemoglobin, red blood cells, platelets, and hematocrit levels at higher doses, indicating potential hematotoxic effects. Histopathological examinations corroborated these results, revealing extensive necrosis and fibrosis in liver and kidney tissues, as well as damage in heart, lungs, and spleen at the highest dose. Comparisons with control groups highlighted significant deviations in treated groups, with statistical analysis confirming the significance of these changes (p<0.05). The findings underscore the potential risks associated with high doses of African Mesquite tree extracts, necessitating cautious use in traditional medicine. This study contributes to the growing body of evidence on the safety profiles of herbal remedies and highlights the need for stringent regulation and monitoring of their use. Future research should focus on long-term toxicity, identification of specific bioactive compounds, and clinical studies in humans to establish safe dosage guidelines. Public awareness campaigns, healthcare provider training, and robust regulatory frameworks are recommended to ensure the safe use of herbal medicines.
Related Project Materials
RELATIONSHIP AMONG ACADEMIC STRESS, MOTIVATION AND ACADEMIC ACHIEVEMENT OF NCE STUDENTS OF FCT COLLEGE OF EDUCATION, ZUBA, NIGERIA
ABSTRACT
This study investigated the relationship among academic stress, motivation and academic achievement of NCE students of FCT Colle...
AN INVESTIGATION ON THE ROLE AND PERFORMANCE OF GOVERNMENT SUPPORT AGENCIES IN THE GROWTH OF ENTERPRENUERSHIP IN ENUGU STATE. (A CASE STUDY OF NATIONAL DIRECTORATE OF EMPLOYMENT (N.D.E)
BACKGROUND OF THE STUDY
People first began engaging in entrepreneurial behavior when they started produ...
THE USE OF RADIO BROADCASTING IN RURAL DEVELOPMENT
Abstract
Rural development of my kind in any place can only be meaningfully achieved through a well – planned and...
IMPACT OF BLENDED LEARNING ON ADULT EDUCATION
Abstract: This research investigates the impact of blended learning on adult education, focusing on its effectiveness in enhancing learning ou...
THE IMPACT OF CAPITAL MARKET ON THE ECONOMIC DEVELOPMENT IN NIGERIA (1985-2011)
ABSTRACT
Many efforts have been made towards understanding the relationship between capital market and the economic development of Nigeri...
THE ROLE OF DIGITAL TECHNOLOGIES IN MODERNIZING VOCATIONAL EDUCATION
Abstract: This research investigates the transformative role of digital technologies in mod...
THE PROSPECTS OF INVESTIGATIVE DATA ANALYSIS IN FORENSIC ACCOUNTING ENGAGEMENTS
Abstract: THE PROSPECTS OF INVESTIGATIVE DATA ANALYSIS IN FORENSIC ACCOUNTING ENGAGEMENTS
This research examines the prospects of investi...
DESIGN AND IMPLEMENTATION OF AUTOMATED LIBRARY SYSTEM
STATEMENT OF PROBLEM
In human endeavors, there are a lot of developments, researches, and discoveries, which result in m...
EFFECT OF CLASS SIZE ON STUDENTS’ ACADEMIC PERFORMANCE IN SOCIAL STUDIES
Background to the Study
According to Adeyemi and Adu (2010), it is widely accepted that education is on...
IMPACT OF PRICING AND MARKETING OF BEVERAGE
BACKGROUND OF THE STUDY
Decision about prices of a company’s product and services are among the most important ac...
