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1. ANTIDIABETIC PROPERTIES OF MUCUNA PRURIENS L. (D.C.) SEED EXTRACT AND ITS TABLET FORMULATIONS

73 Student Researchers

ABSTRACT

Diabetes mellitus and its complications continue to be one of the highest causes of morbidity and mortality in recent times. Although many drugs are commercially available for use in the management of diabetes, their side effects and high costs underscore the need for new drugs. Mucuna pruriens (L.) DC. (Fabaceae) is among the plants used in the management of diabetes in the tropics. The antidiabetic and ameliorative effects of the seed ethanolic extract of M. pruriens on a...

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2. ANALGESIC, ANTI-INFLAMMATORY AND ANTI-CONVULSANT ACTIVITIES OF STEM BARKEXTRACT OF Erythrophleumivorense(A Chev) IN RATS AND MICE

73 Student Researchers

ABSTRACT

Erythrophleumivorense isused in traditional medicine for the treatment of convulsion, swellings, body pain and as emetic agents. There is a dearth of scientific information in support of the traditional claims. This study was therefore designed to investigate the analgesic, antiinflammatory and anticonvulsant properties of the methanol extract and fractions ofErythrophleumivorense. Fresh Stem bark of E. ivorense was air dried,ground to powdery form and was extracted using 7...

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3. AN INTERVENTIONAL STUDY ON ADHERENCE AND BLOOD PRESSURE CONTROL IN A TERTIARY HEALTH FACILITY IN NORTH-WEST NIGERIA

73 Student Researchers

ABSTRACT

The prevalence of hypertension in Sub-Saharan Africa has experienced a tremendous increase due to low awareness, treatment and control rates. Despite the scientific and medical advancements, many people are not aware that they have the disease, and fewer than half of those who are aware are adequately treated, thereby leading to increased morbidity and mortality due to complications such as stroke, ischaemic heart disease and renal failure. Non-adherence to antihypertensive...

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4. STUDIES ON THE ANTIVENOM ACTIVITIES OF THE AQUEOUS EXTRACTS OF PAULLINIA PINNATA AND DETARIUM MICROCARPUM AGAINST ECHIS CARINATUS (CARPET VIPER) VENOM

73 Student Researchers

ABSTRACT

In rural savannah areas of Nigeria, Echics ocellatus (Carpet viper) is responsible for high incidence of snakebite morbidity and mortality. The snakebites are commonly treated with plant extracts in form of traditional medicine. The antivenom activity of Paullinia pinnata Linn and Detarium microcarpum Guill and Perr, popular herbs used in the treatment of Echis ocellatus bites are of great interest and were investigated in vivo and in vitro against the venom (2mg/kg) of Ech...

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5. PHARMACOLOGICAL EFFECTS OF METHANOLIC EXTRACT OF GARCINIA KOLA (HECKEL) SEED ON THE REPRODUCTIVE PROFILES OF SOME MALE EXPERIMENTAL ANIMALS

73 Student Researchers

ABSTRACT

Garcinia kola is commonly consumed in Nigeria in social ceremonies and for leisure purposes. It is speculated to enhance sexual performance in males. The effects of methanolic extract of Garcinia kola seed on the male reproductive profiles of rats were determined at oral doses of 125, 250 and 500 mg/kg for 20 and 60 days respectively. The animals were administered the extract orally for either 20 or 60 days after which analysis of the parameters were carried out using known...

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6. EVALUATION OF SOME NATURAL AND SYNTHETIC PRODUCTS AGAINST AFRICAN TRYPANOSOMIASIS

73 Student Researchers

ABSTRACT

The chemotherapy of African trypanosomiasis, a fatal protozoal disease of man and animals is beset with many problems including a limited repertoire of expensive compounds, drug toxicity and resistance and protracted treatment protocols. In order to improve chemotherapy, some natural and synthetic products were evaluated against African trypanosomiasis using in vitro and in vivo assays. Honey, extracts of Brassica oleracea and of frog and snakes (viper and cobra) skins were...

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7. ETHNOPHARMACOLOGICAL AND PHYTOCHEMICAL PROPERTIES OF SOME PLANTS USED IN THE MANAGEMENT OF PAIN

73 Student Researchers

ABSTRACT

Pain is a worldwide problem and is associated with most disease conditions. The properties of herbs used to treat pain were investigated with the aim of confirming their use and finding out some pharmacological properties that may augment their analgesic activity. A total of eighteen plants (Erythrina senegalesis, Nauclea latifollia, Kizelia africana, Pseudocedrela kotchyi, Crotalaris spp., Boswellia dalzielli, Khaya senegalensis, Annona senegalensis, Xylopia aethiopica, Fi...

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8. THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS

73 Student Researchers

ABSTRACT

The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official methods. The drugs complied with the B.P (1993) requirements stated in their monographs. A high performance liquid chromatography (HPLC) method was developed for the analysis of plasma chlorpropamide co...

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9. THE EFFECT OF QUININE-ARTESUNATE CO-ADMINISTRATION ON SOME BIOCHEMICAL PARAMETERS IN PLASMODIUM BERGHEI PARASITIZED SWISS ALBINO MICE AND RATS

73 Student Researchers

ABSTRACT

Malaria has been the leading cause of morbidity and mortality in most Sub-saharan Africa and Southeastern Asia. Combination therapy has been recommended for treatment of malaria and this could lead to drug-drug interaction. This work titled “The effect of Quinine-Artesunate co-administration on some biochemical parameters on healthy and Plasmodium berghei parasitized Swiss albino mice and rats” was carried out to investigate the effect of Quinine (60 mg/kg)-Arte...

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10. SPECTROPHOTOMETRIC DETERMINATION AND STABILITY STUDIES OF ARTEMETHER IN ARTEMETHER-LUMEFANTRINE SUSPENSIONS MARKETTED IN NIGERIA

73 Student Researchers

ABSTRACT

The increasing use of artemether-lumefantrine combination as an effective treatment for resistant malaria demands the need for analytical methods for the quality control of these drugs in tablets and suspensions. Though some UV Spectrophotometric methods have been developed for quantification of artemether in various biological fluids and formulations, they require strainous heating conditions which is a limitation. This limitation coupled with non-availability of HPLC henc...

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11. SOME NEUROPHARMACOLOGICAL PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS INGENS (MIQUEL) MIQUEL IN MICE AND CHICKS

73 Student Researchers

ABSTRACT

Ficus ingens (Miquel) Miquel belongs to the Moraceae family. In some African countries, extracts of the bark are administered to cows with a low milk production, and to people suffering from anaemia, piles and diarrhea. The behavior of living organisms is a visible manifestation of activity of the central nervous system, and mental and behavioural disorders pose a burden to the affected individual and the society at large, and anxiety disorders are inclusive occurring as th...

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12. PSYCHOACTIVE SUBSTANCE USE AMONG PSYCHIATRIC OUTPATIENTS OF A TERTIARY HOSPITAL IN NIGERIA

73 Student Researchers

ABSTRACT

Psychoactive substances and mental illness is a common comorbidity with poor treatment outcome on patients in some parts of the world. In Nigeria, there is dearth of information on the use of psychoactive substance in mentally-ill patients and their effects. This study investigated the influence of socio-demographic factors, prevalence and types of psychoactive substance use and the effect of these substances on adherence to prescribed medication among psychiatric out-patie...

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13. PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF BACTERIAL ISOLATES FROM CASES OF BACTERIURIA IN ABUJA AND ENVIRON

73 Student Researchers

ABSTRACTS

Urinary tract infections (UTI) are systemic infections that pose great problem to the health care delivery system worldwide. More importantly, the uropathogenic isolates are becoming more resistant to commonly used antimicrobial agents. In order to evaluate the extent of significant bacteriuria in Abuja and environs, pre-study survey by way of questionnaire was carried out. The outcome showed a high prevalence of significant bacteriuria in Abuja and surrounding settlements...

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14. PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON THE LEAF EXTRACT OF STEREOSPERMUM KUNTHIANUM (BIGNONIACEAE)

73 Student Researchers

ABSTRACT

Stereospermum kunthianum (Bignoniacea) herb is used in Hausa ethnomedicine in treating bronchitis, veneral diseases, diarrheoa and dysentery. It is also used in the treatment of ulcers, leprosy, skin eruptions, respiratory ailments and gastritis. The plant is common in Northern Nigeria where it is used as abortifacient and as antihypertensive agent. General phytochemical investigation of both petroleum ether and ethanolic extracts of the leaves of Stereospermum, kunthianum...

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15. PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON THE SEEDS OF JATROPHA CURCAS LINN. (EUPHORBIACEAE)

73 Student Researchers

ABSTRACT

Jatropha curcas Linn. (Euphorbiaceae) is a shrub that grows up to 5m in height. It thrives well in tropical countries. It grows in the wild as an uncultivated, non-food plant. It is traditionally used as a living fence to protect gardens from animals. An ethnobotanical survey of the seed of J. curcas was carried out in parts of Zaria and Zonkwa in Kaduna State of Nigeria. The seeds are used in traditional medicine for analgesic, antimicrobial, purgative, laxative and aphrod...

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16. PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF Spermacoce verticillata (Rubiaceae) G.F.W. Meyer

73 Student Researchers

ABSTRACT

The plant Spermacoce verticillata is used in ethnomedicine for the treatment of itches, diarrhoea, sores and other ailments. The hexane soluble fraction of acetone extract of the whole plant Spermacoce verticillata was subjected to phytochemical and antimicrobial screening. The phytochemical techniques employed were dry column vacuum chromatography and preparative thin layer chromatography. The antimicrobial activity was studied using agar diffusion, and broth dilution meth...

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17. PHYTOCHEMICAL AND ANTICONVULSANT STUDIES ON METHANOL EXTRACT OF THE ROOTBARK OFUVARIA CHAMAEP. BEAUV. (ANNONACEAE)

73 Student Researchers

ABSTRACT

Uvariachamae P. Beauv. (Annonaceae) is widely distributed inAfrica, the plant species are used in traditional medicine as an anti-inflamatory, antimalarial, and analgesic. It is also used for treatment of jaundice, epilepsy and microbial infections. The powdered rootbark of U.chamaewas extracted with methanol using maceration method and the resulting crude methanol extract (CME) was solvent fractionated to give hexane (HF), chloroform (CF), ethylacetate (EF) and n-Butanol (...

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18. PHYTOCHEMICAL AND ANTI BACTERIAL STUDIES ON THE STEM BARK OF LANNEA BARTERI. (OLIV.) ENGL. (ANACARDIACEAE)

73 Student Researchers

ABSTRACT

Lannea bartei (Oliv.) Engl. is a plant with medicinal and commercial uses found usually in the tropical regions like Africa especially Ivory Coast. The plant is used traditionally to treat various diseases including wound healing and as anti diarrhoea. This research is aimed at investigating the wound healing claim which is due to anti bacterial property of the stem bark of the plant. Powdered stem bark of the plant (2 kg) was extracted with methanol using maceration techni...

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19. PHARMACOLOGICAL RATIONALE FOR THE USE OF SOME MEDICINAL PLANTS AS ANTIEPILEPTIC AGENTS IN NIGERIA

73 Student Researchers

ABSTRACT

The effects of the hydro-alcoholic root bark extracts of C. edulis and B. aegyptiaca were studied on pentylenetetrazole (PTZ) and Maximal electroshock (MES)-induced seizures in animal models. The effects of Flumazenil and Naloxone were studied on the anticonvulsant activity of the plant extracts to determine their possible mechanisms of anticonvulsant action. The intraperitoneal LD50 of the hydro-alcoholic root bark extracts of C. edulis and B. aegyptiaca were found to be 2...

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20. PHARMACOLOGICAL EVALUATION OF THREE LOCALLY USED MEDICINAL PLANTS AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

73 Student Researchers

ABSTRACT

Drugs from plant and animal sources are increasingly becoming important in the therapeutic management of liver diseases. This study was undertaken to evaluate the prophylactic and curative effects of methanolic extracts of Balanites aegyptiaca root, Boswellia dalzielii stem bark, Ipomoea asarifolia leaves and their mixture against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Liver damage was induced by intraperitoneal injection of 0.5 ml/kg carbon tetrachlori...

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21. PHARMACOGNOSTIC AND ANTIBACTERIAL STUDIES OF THE LEAF EXTRACTS OF SWARTZIA MADAGASCARIENSIS DESV (FABACEAE)

73 Student Researchers

ABSTRACT

This study evaluated the pharmacognostic standards and antibacterial properties of the leaf extracts of Swartzia madagascariensis Desv (Fabaceae). This plant is widely distributed in Northern part of Nigeria; it has been exploited for both its medicinal and economic importance. It is used in the treatment of infections such as cutaneous wounds. Microscopic, chemomicroscopic, quantitative microscopic studies, qualitative and thin layer chromatographic studies, toxicity studi...

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22. PHARMACOGNOSTIC AND ANTIBACTERIAL STUDIES OF ACACIA SIEBERIANA VAR WOODII (FABACEAE) STEM BARK

73 Student Researchers

ABSTRACT

Acacia sieberiana var. Woodii (Fabaceae) is traditionally used as a remedy for stomach aches and ulcers among some localities in Northern Nigeria. The plant was investigated sequel to the reports of its ethnomedicine uses in the management of stomach ache and ulcers. Anatomical and physical constants studies were carried out using standard procedures. Phytochemical (preliminary studies, thin layer and column chromatography) were also carried out on the hexane and methanol e...

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23. PHARMACOGNOSTIC AND PRO-FERTILITY EVALUATIONS OF DRACAENA ARBOREA (WILLD) LINN. (DRACAENACEAE)

73 Student Researchers

ABSTRACT

The plant Dracaena arborea (Willd) Linn is a member of the Dracaenaceae family. It grows abundantly in western Nigeria where its leaves are used as traditional herbal treatment for male infertility and as aphrodisiacs and also in the treatment of gonorrhoea, viral ailments like small pox, chicken pox, and measles, epilepsy and stomach troubles. This work was aimed at providing some pharmacognostic standards for the leaf of Dracaena arborea (Willd) and also to provide a scie...

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24. PHARMACOECONOMIC ANALYSIS OF HIV/AIDS MANAGEMENT AT MURTALA MUHAMMAD SPECIALIST HOSPITAL, KANO, NIGERIA

73 Student Researchers

ABSTRACT

The HIV/AIDS pandemic has resulted in mortality surge and life expectancy drop throughout the world. Developing countries are mostly affected due to their limited health care system and resources to handle the increasing costs of management of HIV/AIDS and associated opportunistic infections. The objective of this study is to estimate direct and indirect costs of managing HIV/AIDS to both the health sector and the patients, at Murtala Muhammad Specialist Hospital, Kano (MMS...

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25. LEVELS OF CHROMIUM IN SOME SELECTED MEAT PRODUCTS, FRUITS AND DRINKS IN ZARIA AND ENVIRONS

73 Student Researchers

ABSTRACT

Chromium has been known to be a micronutrient for mammals for more than four decades. But progress in elucidating the role of Chromium has proceeded slowly. However, recent studies have shown a potential role of Chromium in maintaining proper Carbohydrate and lipid metabolism at the molecular level. This study quantitatively determined the level of chromium in meat products, fruits and drinks. Sample (Meat products, fruits and Drinks), were purchased from Zaria market and e...

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